Compare Doxycycline vs. Benzamycin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Vibramycin
(Doxycycline)

Benzamycin
(Benzoyl Peroxide / Erythromycin)

Treats bacterial infections. Vibramycin (Doxycycline) is good for treating many bacterial infections. It is also available as generic. However, it can make birth control pills less effective. You also have to protect yourself against sunburn.Topical treatment for acne. Benzamycin (Benzoyl Peroxide / Erythromycin) is a topical combination acne treatment that may work better for people who didn't see an improvement when taking either medicine alone or simply don't want to take pill medication. You need to be careful because it can bleach your hair, clothing and other fabrics. It also needs to be stored in the refrigerator and is only good for three months..
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
No pricing data for this drug at this filter setting. Try searching onGoodRx
Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.223300970873787Doxycycline
Reviews for Vibramycin (Doxycycline)
50%
of people say Vibramycin (Doxycycline) is worth it
34%
say it works well
23%
say it's a big hassle
Reviews for Benzamycin (Benzoyl Peroxide / Erythromycin)
54%
+4% vs. Vibramycin (Doxycycline)
26%
8% vs. Vibramycin (Doxycycline)
12%
+11% vs. Vibramycin (Doxycycline)
Side effects
DoxycyclineBenzamycin

The Doxycycline FDA package insert doesn’t have numbers about how common side effects are.

More about Doxycycline side effects »

The Benzamycin FDA package insert doesn’t have numbers about how common side effects are.

More about Benzamycin side effects »
How it works
DoxycyclineBenzamycin
Vibramycin (Doxycycline) is a tetracycline antibiotic. It stops bacteria by preventing them from reproducing and repairing themselves.Benzamycin (Benzoyl Peroxide / Erythromycin) is a combination topical medicine. Erythromycin (an antibiotic) kills bacteria that cause acne. Benzoyl peroxide works to fight the bacteria and shed acne-affected skin.
Type of medication
DoxycyclineBenzamycin
Antibiotic
Tetracycline
Prescription only
Acne agent
Antibiotic
Prescription only
Available as
DoxycyclineBenzamycin
  • Pill
  • Delayed release capsule
  • Liquid
  • Cream, gel, or ointment
Used for (click to learn more)
DoxycyclineBenzamycin
Risk factors for serious side effects
DoxycyclineBenzamycin
  • Age 8 years or younger
  • Using oral birth control pills
  • Long antibiotic treatment period
      • Women of childbearing age
      • Women of childbearing age
      • Overweight or obese
      • Taking isotretinoin (Accutane)
      Detailed Vibramycin (Doxycycline) risks & warnings »
        • Using other medicines or products that irritate the skin
        • Eczema
        • Extreme temperatures (hot or cold)
          • Long-term use of Benzamycin (Benzoyl Peroxide / Erythromycin)
          Detailed Benzamycin (Benzoyl Peroxide / Erythromycin) risks & warnings »
          Pregnancy category
          DoxycyclineBenzamycin
          DFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          CFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          Alcohol
          No specific alcohol-related info.No specific alcohol-related info.
          Food
          • Has to be taken with plenty of water and food and you have to stay upright for 30 minutes afterwards to avoid stomach irritation.
          • Take with plenty of food and liquids.
          No specific food-related info.
          Kidneys and liver
          No specific kidneys and liver-related info.No specific kidneys and liver-related info.
          Sex
          No specific sex-related info.No specific sex-related info.
          Sleep
          No specific sleep-related info.No specific sleep-related info.
          Weight
          No specific weight-related info.
          • Not the best choice if you're pregnant. Benzamycin is categorized as pregnancy Category C (weight risks vs benefits) because of the benzoyl peroxide part.
          Upsides and benefits
          DoxycyclineBenzamycin
          • Available in generic.
          • Available in different forms: tablet, capsule, and suspension.
          • Used to treat many types of bacterial infections.
          • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
          • Benzamycin works better to reduce bacteria in oil glands and improve overall signs and symptoms of acne than either medicine alone.
          • Reduces bacteria on the skin, which "calms" the skin down (lowers the inflammatory response) in acne.
          • Combining an antibiotic with benzoyl peroxide lowers the chances of Benzamycin not working as well over time.
          • Although Benzamycin can irritate the skin, a true skin allergy is rare.
          • Can be used in combination with acne pill medicine if your doctor thinks you need it.
          Downsides and risks
          DoxycyclineBenzamycin
          • Can't be used in pregnant women and children under 8 years old.
          • Makes your skin more sensitive to the sun.
          • Has to be taken with plenty of water and food and you have to stay upright for 30 minutes afterwards to avoid stomach irritation.
          • Can make birth control less effective.
          • Can cause diarrhea.
          • There's a risk of irritation with anything you apply to your skin and this is no different. Benzamycin, contains a topical antibiotic and can cause redness, peeling, abnormal dryness or stinging, tightening, or burning sensations.
          • It's rare, that a serious allergic reaction would occur, but it's a good idea to test a small area of skin before using on any larger or sensitive areas
          • Can cause severe inflammation of the large intestine (pseudomembranous colitis).
          • Not the best choice if you're pregnant. Benzamycin is categorized as pregnancy Category C (weight risks vs benefits) because of the benzoyl peroxide part.
          • Can cause bleaching of hair and clothing.
          • You'll need to stay out of the sun or apply a sunscreen if you go outdoors.
          Tips from our pharmacists for people taking the medication
          DoxycyclineBenzamycin
          • Take the medication exactly how your doctor tells you to.
          • If you're using birth control pills, this medication can make them less effective.
          • Wear sunblock if you have to go out into the sun since your skin can become more sensitive to sunburn.
          • Can cause diarrhea, nausea or vomiting.
          • Space out any vitamins by at least two hours.
          • Take with plenty of food and liquids.
          • Don't take any medications with bismuth (Pepto-Bismol, Kaopectate) while taking this medication.
          • Don't lie down for at least 30 minutes after taking this medication.
          • Combination medicine you apply to your skin to treat acne.
          • Apply a thin film to clean and dry affected skin twice a day- in the morning and evening.
          • Store in the refrigerator, but don't freeze.
          • The pharmacist mixes the medicine when you pick it up at the drugstore. You'll need to use it within three months of this date or dispose of it properly.
          • Let your doctor know if you notice abdominal discomfort, pain or diarrhea after starting this medicine.
          • Using a moisturizer that doesn't block your pores (non-comedogenic) may help lessen common side effects of skin dryness and peeling.
          • Taking good care of your skin is an important part of treating acne. Lightly wash with warm water and non-soap-based or gentle cleanser.
          Learn more
          More about DoxycyclineSide effectsReviews & ratingsAlternativesFDA package insert
          More about BenzamycinSide effectsReviews & ratingsAlternativesFDA package insert