Compare Doxycycline vs. Cleocin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Vibramycin
(doxycycline)

Cleocin T
(clindamycin phosphate)

Treats bacterial infections. Vibramycin (Doxycycline) is good for treating many bacterial infections. It is also available as generic. However, it can make birth control pills less effective. You also have to protect yourself against sunburn.Topical treatment for acne. Cleocin T (Clindamycin Phosphate) is good for treating many bacterial infections and is available as a generic. If you're taking the vaginal form, you have to avoid sex and tampons for the period your doctor tells you to. The topical form can cause skin sensitivity and irritation.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.27Doxycycline
Reviews for Vibramycin (doxycycline)
49%
of people (All ages) say Vibramycin (doxycycline) is worth it
36%
say it works well
24%
say it's a big hassle
112 reviews
Have you used Vibramycin (doxycycline)?
Worth itNot sureNot worth it
Reviews for Cleocin T (clindamycin phosphate)
57%
+8% better vs. Vibramycin (doxycycline)
43%
+7% better vs. Vibramycin (doxycycline)
19%
+5% better vs. Vibramycin (doxycycline)
115 reviews
Have you used Cleocin T (clindamycin phosphate)?
Worth itNot sureNot worth it
Side effects
DoxycyclineCleocin
  • Any adverse event 40%
  • Nausea 13%
  • Vomiting 8%
  • Diarrhea 3%
  • Bacterial vaginitis 3%
  • Headache 2%
  • Upper abdominal pain 2%
  • Vaginal yeast infection 2%
More Doxycycline side effects »
  • Any side effect 21%
  • Vaginal moniliasis 8%
  • Vulvovaginitis 6%
  • Vulvovaginal disorder 3%
  • Moniliasis (body) 2%
  • Fungal infection 2%
More Cleocin side effects »
How it works
DoxycyclineCleocin
Vibramycin (Doxycycline) is a tetracycline antibiotic. It stops bacteria by preventing them from reproducing and repairing themselves.Cleocin T (Clindamycin Phosphate) is an antibiotic and acne medicine. It kills bacteria by preventing them from reproducing and repairing themselves.
Type of medication
DoxycyclineCleocin
Prescription only
Prescription only
Available as
DoxycyclineCleocin
  • Pill
  • Delayed release capsule
  • Liquid
  • Topical
  • Cream, gel, or ointment
  • Foam
  • Vaginal cream
  • Vaginal suppository
  • Injection
Used for
DoxycyclineCleocin
Risk factors for serious side effects
DoxycyclineCleocin
  • Age 8 years or younger
  • Using oral birth control pills
  • Long antibiotic treatment period
      • Women of childbearing age
      • Women of childbearing age
      • Overweight or obese
      • Taking isotretinoin (Accutane)
      Detailed Vibramycin (doxycycline) risks & warnings »
        • History of liver disease
          Detailed Cleocin T (clindamycin phosphate) risks & warnings »
          Pregnancy

          Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          Food
          DoxycyclineCleocin
          No food related info.
          • Can be taken with or without food.
          Kidneys and liver
          DoxycyclineCleocin
          No kidneys and liver related info.
          • There have been reports of liver damage that can require hospitalization or can cause death. These have been rare. Talk to your doctor if you notice pain in your abdomen, loss of appetite, yellowing of your skin or eyes, or dark colored urine.
          Pain
          DoxycyclineCleocin
          No pain related info.
          • The forms taken by mouth can cause diarrhea, vomiting, and abdominal pain.
          Upsides and benefits
          DoxycyclineCleocin
          • Available in generic.
          • Available in different forms: tablet, capsule, and suspension.
          • Used to treat many types of bacterial infections.
          • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
          • Available in generic.
          • Topical form treats acne.
          • Available in different oral forms: tablet, capsule, and suspension.
          • Available in forms to treat skin infections and vaginal infections.
          • Used to treat many types of bacterial infections.
          • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
          • Can be taken with or without food.
          Downsides and risks
          DoxycyclineCleocin
          • Can't be used in pregnant women and children under 8 years old.
          • Makes your skin more sensitive to the sun.
          • Has to be taken with plenty of water and food and you have to stay upright for 30 minutes afterwards to avoid stomach irritation.
          • Can make birth control less effective.
          • Can cause diarrhea.
          • Have to take the oral forms with a full glass of liquid or with food since it can cause irritation in your stomach and esophagus.
          • If you're taking the vaginal form, you have to avoid sex and not use tampons for the period your doctor tells you to.
          • If you're allergic to aspirin, your doctor may have to prescribe an alternate.
          • If you have to take live vaccines, talk to your doctor when to take them since Clindamycin can make it less effective.
          • If you're taking the topical form, it can cause sensitivity and irritation.
          Tips from our pharmacists for people taking the medication
          DoxycyclineCleocin
          • Take the medication exactly how your doctor tells you to.
          • If you're using birth control pills, this medication can make them less effective.
          • Wear sunblock if you have to go out into the sun since your skin can become more sensitive to sunburn.
          • Can cause diarrhea, nausea or vomiting.
          • Space out any vitamins by at least two hours.
          • Take with plenty of food and liquids.
          • Don't take any medications with bismuth (Pepto-Bismol, Kaopectate) while taking this medication.
          • Don't lie down for at least 30 minutes after taking this medication.
          • The forms taken by mouth can cause diarrhea, vomiting, and abdominal pain.
          • Take this medication exactly how your doctor tells you to.
          • Store the suspension at room temperature.
          • If you're using the topical form, it can take a few weeks to see the full effect.
          • Keep the topical form out of your eyes, nose and mouth.
          • If you're using the topical form, Don't put makeup or bandages over it.
          • If you're using the vaginal form, don't have sex before the doctor tells you it's ok.
          Learn more
          More about DoxycyclineSide effectsReviews & ratingsAlternativesFDA package insert
          Have you used Vibramycin (doxycycline)?
          Worth itNot sureNot worth it
          More about CleocinSide effectsReviews & ratingsAlternativesFDA package insert
          Have you used Cleocin T (clindamycin phosphate)?
          Worth itNot sureNot worth it