Compare Doxycycline vs. Cleocin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Vibramycin
(Doxycycline)

Cleocin T
(Clindamycin Phosphate)

Treats bacterial infections. Vibramycin (Doxycycline) is good for treating many bacterial infections. It is also available as generic. However, it can make birth control pills less effective. You also have to protect yourself against sunburn.Topical treatment for acne. Cleocin T (Clindamycin Phosphate) is good for treating many bacterial infections and is available as a generic. If you're taking the vaginal form, you have to avoid sex and tampons for the period your doctor tells you to. The topical form can cause skin sensitivity and irritation.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.223300970873787Doxycycline
Reviews for Vibramycin (Doxycycline)
50%
of people say Vibramycin (Doxycycline) is worth it
34%
say it works well
23%
say it's a big hassle
Reviews for Cleocin T (Clindamycin Phosphate)
57%
+7% vs. Vibramycin (Doxycycline)
43%
+9% vs. Vibramycin (Doxycycline)
20%
+3% vs. Vibramycin (Doxycycline)
Side effects
DoxycyclineCleocin

The Doxycycline FDA package insert doesn’t have numbers about how common side effects are.

More about Doxycycline side effects »
  • Vaginal moniliasis 6%
More Cleocin side effects »
How it works
DoxycyclineCleocin
Vibramycin (Doxycycline) is a tetracycline antibiotic. It stops bacteria by preventing them from reproducing and repairing themselves.Cleocin T (Clindamycin Phosphate) is an antibiotic and acne medicine. It kills bacteria by preventing them from reproducing and repairing themselves.
Type of medication
DoxycyclineCleocin
Antibiotic
Tetracycline
Prescription only
Acne agent
Antibiotic
Prescription only
Available as
DoxycyclineCleocin
  • Pill
  • Delayed release capsule
  • Liquid
  • Topical
  • Cream, gel, or ointment
  • Foam
  • Vaginal cream
  • Vaginal suppository
  • Injection
Used for (click to learn more)
DoxycyclineCleocin
Risk factors for serious side effects
DoxycyclineCleocin
  • Age 8 years or younger
  • Using oral birth control pills
  • Long antibiotic treatment period
      • Women of childbearing age
      • Women of childbearing age
      • Overweight or obese
      • Taking isotretinoin (Accutane)
      Detailed Vibramycin (Doxycycline) risks & warnings »
        • History of liver disease
          Detailed Cleocin T (Clindamycin Phosphate) risks & warnings »
          Pregnancy category
          DoxycyclineCleocin
          DFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          BFDA pregnancy category (Probably safe)

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          See the FDA package insert
          Alcohol
          No specific alcohol-related info.No specific alcohol-related info.
          Food
          • Has to be taken with plenty of water and food and you have to stay upright for 30 minutes afterwards to avoid stomach irritation.
          • Take with plenty of food and liquids.
          • Have to take the oral forms with a full glass of liquid or with food since it can cause irritation in your stomach and esophagus.
          • Can be taken with or without food.
          Kidneys and liver
          No specific kidneys and liver-related info.No specific kidneys and liver-related info.
          Sex
          No specific sex-related info.
          • If you're taking the vaginal form, you have to avoid sex and not use tampons for the period your doctor tells you to.
          • If you're using the vaginal form, don't have sex before the doctor tells you it's ok.
          Sleep
          No specific sleep-related info.No specific sleep-related info.
          Weight
          No specific weight-related info.No specific weight-related info.
          Upsides and benefits
          DoxycyclineCleocin
          • Available in different forms: tablet, capsule, and suspension.
          • Available in generic.
          • Used to treat many types of bacterial infections.
          • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
          • Topical form treats acne.
          • Available in different oral forms: tablet, capsule, and suspension.
          • Available in forms to treat skin infections and vaginal infections.
          • Can be taken with or without food.
          • Available in generic.
          • Used to treat many types of bacterial infections.
          • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
          Downsides and risks
          DoxycyclineCleocin
          • Can't be used in pregnant women and children under 8 years old.
          • Makes your skin more sensitive to the sun.
          • Has to be taken with plenty of water and food and you have to stay upright for 30 minutes afterwards to avoid stomach irritation.
          • Can make birth control less effective.
          • Can cause diarrhea.
          • Have to take the oral forms with a full glass of liquid or with food since it can cause irritation in your stomach and esophagus.
          • If you're taking the vaginal form, you have to avoid sex and not use tampons for the period your doctor tells you to.
          • If you're allergic to aspirin, your doctor may have to prescribe an alternate.
          • If you have to take live vaccines, talk to your doctor when to take them since Clindamycin can make it less effective.
          • If you're taking the topical form, it can cause sensitivity and irritation.
          Tips from our pharmacists for people taking the medication
          DoxycyclineCleocin
          • Take the medication exactly how your doctor tells you to.
          • If you're using birth control pills, this medication can make them less effective.
          • Wear sunblock if you have to go out into the sun since your skin can become more sensitive to sunburn.
          • Can cause diarrhea, nausea or vomiting.
          • Space out any vitamins by at least two hours.
          • Take with plenty of food and liquids.
          • Don't take any medications with bismuth (Pepto-Bismol, Kaopectate) while taking this medication.
          • Don't lie down for at least 30 minutes after taking this medication.
          • The forms taken by mouth can cause diarrhea, vomiting, and abdominal pain.
          • Take this medication exactly how your doctor tells you to.
          • Store the suspension at room temperature.
          • If you're using the topical form, it can take a few weeks to see the full effect.
          • Keep the topical form out of your eyes, nose and mouth.
          • If you're using the topical form, Don't put makeup or bandages over it.
          • If you're using the vaginal form, don't have sex before the doctor tells you it's ok.
          Learn more
          More about DoxycyclineSide effectsReviews & ratingsAlternativesFDA package insert
          More about CleocinSide effectsReviews & ratingsAlternativesFDA package insert