Compare doxycycline vs. Erygel

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Vibramycin (doxycycline)

Prescription only

Akne-Mycin (Erythromycin)

Prescription only
Treats bacterial infections.

Vibramycin (doxycycline) is good for treating many bacterial infections, but can increase your skin's sensitivity to sunlight and make you more likely to get a sunburn or rash.

4.3/ 7 average rating with 112 reviewsfordoxycycline
Topical treatment for acne.

Akne-Mycin (Erythromycin) is a very common acne treatment you apply to the skin that may work better when combined with other topical medicines.

4.5/ 7 average rating with 93 reviewsforErygel
Upsides
  • Vibramycin (doxycycline) is a good alternative for some types of bacterial infections for people who are allergic to penicillin.
  • Available in generic.
  • Available as a liquid for those who have trouble swallowing.
  • Vibramycin (doxycycline) is safe for people age 65 or older and those who have kidney problems.
  • Applying erythromycin to the skin reduces the amount of acne bacteria and "calms" the skin down (lowers the inflammatory response) in acne.
  • Available in a gel formulation which may be better if your skin is very oily.
  • Better choice if you're pregnant. erythromycin is categorized as pregnancy Category B (likely safe) as compared to similar topical medicines that are Category C (weigh risks vs benefits).
Downsides
  • Vibramycin (doxycycline) makes your skin more sensitive to the sun.
  • Vibramycin (doxycycline) can make some birth control less effective, so you may have to use barrier methods (like condoms) while on it.
  • Vitamins, iron supplements, or antacids can't be taken at the same time as Vibramycin (doxycycline).
  • Vibramycin (doxycycline) can cause severe diarrhea that is usually watery and bloody, as late as up to 2 months after finishing the medicine.
  • There's a risk of irritation with anything you apply to your skin and this is no different. erythromycin, like other topical antibiotics, can cause skin irritation and may appear as redness, peeling, abnormal dryness or stinging, tightening, or burning sensations.
  • It's rare, that a serious allergic reaction would occur, but it's a good idea to test a small area of skin before using on any larger or sensitive areas
  • Studies show it works better when combined with other topical medicines to fight acne and reduce the risk of it losing its effectiveness over time.
  • Can cause severe inflammation of the large intestine (pseudomembranous colitis)
  • Stop using if you don't notice any improvement in your acne after 6-8 weeks. The most time you can use it is three months.
Used for
Dosage forms
  • Pill
  • Delayed release pill
  • Liquid
  • Cream, gel, or ointment
  • Topical solution
Price
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$36.81
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$9.99
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Reviews
112 
49%
think this treatment is worth it
36%
think this treatment works well
24%
think this treatment is a hassle

Have you used Vibramycin (doxycycline)?

Leave a review
93 
46%
think this treatment is worth it
34%
think this treatment works well
19%
think this treatment is a hassle

Have you used Akne-Mycin (Erythromycin)?

Leave a review
Side effects
The Vibramycin (doxycycline) FDA package insert doesn’t have numbers about how common side effects are.
1possible side effects
  • Burning
    25%
See more detailed side effects
Risks and warnings
  • Color changes in teeth of young children and unborn babies

    Age 8 or younger

    ...and 2 more risk factors

  • Severe diarrhea

    Using Vibramycin (doxycycline) for a long period of time

  • Sunburn or rash

    Being in the sun for a long period of time

    ...and 1 more risk factors

  • Harm to fetus (unborn baby)

    Women who can potentially or want to become pregnant

    ...and 1 more risk factors

See more detailed risks and warnings
  • Skin irritation

    Using other medicines or products that irritate the skin

    ...and 2 more risk factors

See more detailed risks and warnings