Compare doxycycline vs. Keflex

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Vibramycin (doxycycline)

Prescription only

Keflex (cephalexin)

Prescription only
Treats bacterial infections.

Vibramycin (doxycycline) is good for treating many bacterial infections, but can increase your skin's sensitivity to sunlight and make you more likely to get a sunburn or rash.

3.2/ 5 average rating with 112 reviewsfordoxycycline
Treats bacterial infections.

Keflex (cephalexin) is good for treating many bacterial infections, and is available as a generic.

3.7/ 5 average rating with 686 reviewsforKeflex
Upsides
  • Vibramycin (doxycycline) is a good alternative for some types of bacterial infections for people who are allergic to penicillin.
  • Available in generic.
  • Available as a liquid for those who have trouble swallowing.
  • Vibramycin (doxycycline) is safe for people age 65 or older and those who have kidney problems.
  • Available in generic.
  • Available in different forms: tablet, capsule, and suspension.
  • Used to treat many types of bacterial infections.
  • Can be taken with or without food.
  • Generally few side effects compared with other antibiotics.
Downsides
  • Vibramycin (doxycycline) makes your skin more sensitive to the sun.
  • Vibramycin (doxycycline) can make some birth control less effective, so you may have to use barrier methods (like condoms) while on it.
  • Vitamins, iron supplements, or antacids can't be taken at the same time as Vibramycin (doxycycline).
  • Vibramycin (doxycycline) can cause severe diarrhea that is usually watery and bloody, as late as up to 2 months after finishing the medicine.
  • Can cause diarrhea.
  • You may need to take Keflex (cephalexin) 2 to 4 times a day, which can be hard to remember.
  • If you're allergic to penicillins or other antibiotics, you might not be able to take this medicine.
Used for
Dosage forms
  • Pill
  • Delayed release pill
  • Liquid
  • Pill
  • Liquid
Price
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Reviews
112 reviews so far
49%
saidit'sworth it
36%
saiditworked well
24%
saidit'sa big hassle

Have you used Vibramycin (doxycycline)?

Leave a review
686 reviews so far
64%
saidit'sworth it
48%
saiditworked well
14%
saidit'sa big hassle

Have you used Keflex (cephalexin)?

Leave a review
Side effects
The Vibramycin (doxycycline) FDA package insert doesn’t have numbers about how common side effects are.
The Keflex (cephalexin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Color changes in teeth of young children and unborn babies
    • Age 8 or younger
    • Women in their last half of pregnancy
    • Infants
  • Severe diarrhea
    • Using Vibramycin (doxycycline) for a long period of time
  • Sunburn or rash
    • Being in the sun for a long period of time
    • Using tanning salons
  • Harm to fetus (unborn baby)
    • Women who can potentially or want to become pregnant
    • Pregnant women
See more detailed risks and warnings
  • Diarrhea
  • New infections while taking Keflex (cephalexin)
    • Weakened immune system
    • Not taking Keflex (cephalexin) correctly
  • Allergic reaction
    • History of penicillin or cephalosporin allergies
See more detailed risks and warnings
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Disclaimer: We don't provide medical advice. If you think you might have a medical emergency, call your doctor or 911 immediately.