Compare Doxycycline vs. Levaquin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Vibramycin
(Doxycycline)

Levaquin
(Levofloxacin)

Treats bacterial infections. Vibramycin (Doxycycline) is good for treating many bacterial infections. It is also available as generic. However, it can make birth control pills less effective. You also have to protect yourself against sunburn.Kills bacteria. Levaquin (Levofloxacin) is good for treating many bacterial infections and is available as generic. However, it can cause damage to your tendons, and make your skin more sensitive to the sun.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.223300970873787Doxycycline
Reviews for Vibramycin (Doxycycline)
50%
of people say Vibramycin (Doxycycline) is worth it
34%
say it works well
23%
say it's a big hassle
Reviews for Levaquin (Levofloxacin)
54%
+4% vs. Vibramycin (Doxycycline)
39%
+5% vs. Vibramycin (Doxycycline)
29%
6% vs. Vibramycin (Doxycycline)
Side effects
DoxycyclineLevaquin

The Doxycycline FDA package insert doesn’t have numbers about how common side effects are.

More about Doxycycline side effects »

The Levaquin FDA package insert doesn’t have numbers about how common side effects are.

More about Levaquin side effects »
How it works
DoxycyclineLevaquin
Vibramycin (Doxycycline) is a tetracycline antibiotic. It stops bacteria by preventing them from reproducing and repairing themselves.Levaquin (Levofloxacin) is an antibiotic. It kills bacteria by preventing them from reproducing and repairing themselves.
Type of medication
DoxycyclineLevaquin
Antibiotic
Tetracycline
Prescription only
Antibiotic
Fluoroquinolone
Prescription only
Available as
DoxycyclineLevaquin
  • Pill
  • Delayed release capsule
  • Liquid
  • Pill
  • Liquid
Used for (click to learn more)
DoxycyclineLevaquin
Risk factors for serious side effects
DoxycyclineLevaquin
  • Age 8 years or younger
  • Using oral birth control pills
  • Long antibiotic treatment period
      • Women of childbearing age
      • Women of childbearing age
      • Overweight or obese
      • Taking isotretinoin (Accutane)
      Detailed Vibramycin (Doxycycline) risks & warnings »
      • Over 60 years of age
      • On long-term steroid use
      • Heart, kidney, or lung transplant
        • History of liver disease
        • Seizures
            • Diabetes
            • Taking medications for diabetes
                Detailed Levaquin (Levofloxacin) risks & warnings »
                Pregnancy category
                DoxycyclineLevaquin
                DFDA pregnancy category (Weigh risks vs. benefits)

                Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                See the FDA package insert
                CFDA pregnancy category (Weigh risks vs. benefits)

                Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                See the FDA package insert
                Alcohol
                No specific alcohol-related info.No specific alcohol-related info.
                Food
                • Has to be taken with plenty of water and food and you have to stay upright for 30 minutes afterwards to avoid stomach irritation.
                • Take with plenty of food and liquids.
                No specific food-related info.
                Kidneys and liver
                No specific kidneys and liver-related info.No specific kidneys and liver-related info.
                Sex
                No specific sex-related info.No specific sex-related info.
                Sleep
                No specific sleep-related info.No specific sleep-related info.
                Weight
                No specific weight-related info.No specific weight-related info.
                Upsides and benefits
                DoxycyclineLevaquin
                • Available in generic.
                • Available in different forms: tablet, capsule, and suspension.
                • Used to treat many types of bacterial infections.
                • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
                • Available in generic.
                • Available in different forms: tablet, capsule, and suspension.
                • Used to treat many types of bacterial infections.
                • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
                Downsides and risks
                DoxycyclineLevaquin
                • Can't be used in pregnant women and children under 8 years old.
                • Makes your skin more sensitive to the sun.
                • Has to be taken with plenty of water and food and you have to stay upright for 30 minutes afterwards to avoid stomach irritation.
                • Can make birth control less effective.
                • Can cause diarrhea.
                • Must be used with caution in people over 60 years of age, or who have had either an organ transplant or on long-term steroid use due to possible tendon rupture.
                • Levofloxacin can make your skin more sensitive to the sun.
                • Can't be used if you've ever had myasthenia gravis.
                • You have to space out any medications with aluminum, magnesium or zinc by at least 2 hours.
                • Can cause changes in taste, headaches, and insomnia.
                Tips from our pharmacists for people taking the medication
                DoxycyclineLevaquin
                • Take the medication exactly how your doctor tells you to.
                • If you're using birth control pills, this medication can make them less effective.
                • Wear sunblock if you have to go out into the sun since your skin can become more sensitive to sunburn.
                • Space out any vitamins by at least two hours.
                • Take with plenty of food and liquids.
                • Don't take any medications with bismuth (Pepto-Bismol, Kaopectate) while taking this medication.
                • Don't lie down for at least 30 minutes after taking this medication.
                • Can cause diarrhea, nausea or vomiting.
                • If you notice pain in your Achilles tendons, contact your doctor.
                • Wear sunscreen if you're going to be out in the sun.
                • Take the medication exactly how the doctor tells you to.
                • Take this medication with plenty of fluids.
                • Space out any medications containing aluminum, magnesium or zinc by at least 2 hours.
                • Can cause changes in taste, headaches and insomnia.
                • Can cause diarrhea, nausea or vomiting.
                Learn more
                More about DoxycyclineSide effectsReviews & ratingsAlternativesFDA package insert
                More about LevaquinSide effectsReviews & ratingsAlternativesFDA package insert