Compare Doxycycline vs. Levaquin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Vibramycin
(doxycycline)

Levaquin
(levofloxacin)

Treats bacterial infections. Vibramycin (Doxycycline) is good for treating many bacterial infections. It is also available as generic. However, it can make birth control pills less effective. You also have to protect yourself against sunburn.Kills bacteria. Levaquin (Levofloxacin) is good for treating many bacterial infections and is available as generic. However, it can cause damage to your tendons, and make your skin more sensitive to the sun.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.27Doxycycline
Reviews for Doxycycline
49%
of people (All ages) say Doxycycline is worth it
36%
say it works well
24%
say it's a big hassle
112 reviews
Have you used Vibramycin (doxycycline)?
Worth itNot sureNot worth it
Reviews for Levaquin
53%
-4% worse vs. Doxycycline
40%
-4% worse vs. Doxycycline
31%
+7% better vs. Doxycycline
Have you used Levaquin (levofloxacin)?
Worth itNot sureNot worth it
Side effects
DoxycyclineLevaquin
  • Any adverse event 40%
  • Nausea 13%
  • Vomiting 8%
  • Diarrhea 3%
  • Bacterial vaginitis 3%
  • Headache 2%
  • Upper abdominal pain 2%
  • Vaginal yeast infection 2%
More Doxycycline side effects »
  • Nausea 7%
  • Headache 6%
  • Diarrhea 5%
  • Insomnia 4%
  • Dizziness 3%
  • Consitpation 3%
  • Abdominal pain 2%
  • Vomiting 2%
  • Dyspepsia 2%
  • Rash 2%
More Levaquin side effects »
How it works
DoxycyclineLevaquin
Vibramycin (Doxycycline) is a tetracycline antibiotic. It stops bacteria by preventing them from reproducing and repairing themselves.Levaquin (Levofloxacin) is an antibiotic. It kills bacteria by preventing them from reproducing and repairing themselves.
Type of medication
DoxycyclineLevaquin
Prescription onlyPrescription only
Available as
DoxycyclineLevaquin
  • Pill
  • Delayed release capsule
  • Liquid
  • Pill
  • Liquid
Used for
DoxycyclineLevaquin
Risk factors for serious side effects
DoxycyclineLevaquin
  • Age 8 years or younger
  • Using oral birth control pills
  • Long antibiotic treatment period
  • Women of childbearing age
Detailed Vibramycin (doxycycline) risks & warnings »
  • Over 60 years of age
  • On long-term steroid use
  • Heart, kidney, or lung transplant
  • History of liver disease
  • Seizures
Detailed Levaquin (levofloxacin) risks & warnings »
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Kidneys and liver
DoxycyclineLevaquin
No kidneys and liver related info.
  • There have been reports of liver damage that can require hospitalization or can cause death. These have been rare. Talk to your doctor if you notice pain in your abdomen, loss of appetite, yellowing of your skin or eyes, or dark colored urine.
Pain
DoxycyclineLevaquin
No pain related info.
  • If you notice redness/inflammation, pain or swelling in your joints or muscles, especially in the Achilles tendon, contact your doctor immediately.
  • Talk to your doctor immediately if you start to feel burning, tingling, numbness, pain or you can't tolerate heat or cold. This could be a sign of nerve damage. It can happen as soon as you start taking the medication and may not go away if you stop it.
  • If you notice pain in your Achilles tendons, contact your doctor.
Upsides and benefits
DoxycyclineLevaquin
  • Available in generic.
  • Available in different forms: tablet, capsule, and suspension.
  • Used to treat many types of bacterial infections.
  • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
  • Available in generic.
  • Available in different forms: tablet, capsule, and suspension.
  • Used to treat many types of bacterial infections.
  • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
Downsides and risks
DoxycyclineLevaquin
  • Can't be used in pregnant women and children under 8 years old.
  • Makes your skin more sensitive to the sun.
  • Has to be taken with plenty of water and food and you have to stay upright for 30 minutes afterwards to avoid stomach irritation.
  • Can make birth control less effective.
  • Can cause diarrhea.
  • Must be used with caution in people over 60 years of age, or who have had either an organ transplant or on long-term steroid use due to possible tendon rupture.
  • Levofloxacin can make your skin more sensitive to the sun.
  • Can't be used if you've ever had myasthenia gravis.
  • You have to space out any medications with aluminum, magnesium or zinc by at least 2 hours.
  • Can cause changes in taste, headaches, and insomnia.
Tips from our pharmacists for people taking the medication
DoxycyclineLevaquin
  • Take the medication exactly how your doctor tells you to.
  • If you're using birth control pills, this medication can make them less effective.
  • Wear sunblock if you have to go out into the sun since your skin can become more sensitive to sunburn.
  • Can cause diarrhea, nausea or vomiting.
  • Space out any vitamins by at least two hours.
  • Take with plenty of food and liquids.
  • Don't take any medications with bismuth (Pepto-Bismol, Kaopectate) while taking this medication.
  • Don't lie down for at least 30 minutes after taking this medication.
  • If you notice pain in your Achilles tendons, contact your doctor.
  • Wear sunscreen if you're going to be out in the sun.
  • Take the medication exactly how the doctor tells you to.
  • Take this medication with plenty of fluids.
  • Space out any medications containing aluminum, magnesium or zinc by at least 2 hours.
  • Can cause diarrhea, nausea or vomiting.
  • Can cause changes in taste, headaches and insomnia.
Learn more
More about DoxycyclineSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Vibramycin (doxycycline)?
Worth itNot sureNot worth it
More about LevaquinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Levaquin (levofloxacin)?
Worth itNot sureNot worth it