Compare doxycycline vs. Levaquin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Vibramycin (doxycycline)

Prescription only

Levaquin (levofloxacin)

Prescription only
Treats bacterial infections.

Vibramycin (doxycycline) is good for treating many bacterial infections, but can increase your skin's sensitivity to sunlight and make you more likely to get a sunburn or rash.

3.2/ 5 average rating with 112 reviewsfordoxycycline
Treats bacterial infections.

Levaquin (levofloxacin) effectively treats different types of bacterial infections, but it is relatively more expensive than some of its alternatives.

3.3/ 5 average rating with 90 reviewsforLevaquin
Upsides
  • Vibramycin (doxycycline) is a good alternative for some types of bacterial infections for people who are allergic to penicillin.
  • Available in generic.
  • Available as a liquid for those who have trouble swallowing.
  • Vibramycin (doxycycline) is safe for people age 65 or older and those who have kidney problems.
  • Available as a generic medicine.
  • Liquid form of Levaquin (levofloxacin) is available for those with trouble swallowing.
  • Treats a variety of bacterial infections.
  • Take only once a day.
  • Can take pill form with or without food.
Downsides
  • Vibramycin (doxycycline) makes your skin more sensitive to the sun.
  • Vibramycin (doxycycline) can make some birth control less effective, so you may have to use barrier methods (like condoms) while on it.
  • Vitamins, iron supplements, or antacids can't be taken at the same time as Vibramycin (doxycycline).
  • Vibramycin (doxycycline) can cause severe diarrhea that is usually watery and bloody, as late as up to 2 months after finishing the medicine.
  • People with diabetes need to check their blood sugar levels regularly while taking Levaquin (levofloxacin).
  • Can't take Levaquin (levofloxacin) at the same time as antacids or vitamins.
  • Levaquin (levofloxacin) can increase your skin's sensitivity to sunlight and make you more likely to get a rash.
  • Relatively more expensive compared to similar alternatives.
  • Associated with serious and some potentially life-threatening side effects.
Used for
Dosage forms
  • Pill
  • Delayed release pill
  • Liquid
  • Pill
  • Liquid
Price
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Reviews
112 reviews so far
49%
saidit'sworth it
36%
saiditworked well
24%
saidit'sa big hassle

Have you used Vibramycin (doxycycline)?

Leave a review
90 reviews so far
53%
saidit'sworth it
40%
saiditworked well
31%
saidit'sa big hassle

Have you used Levaquin (levofloxacin)?

Leave a review
Side effects
The Vibramycin (doxycycline) FDA package insert doesn’t have numbers about how common side effects are.
The Levaquin (levofloxacin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Color changes in teeth of young children and unborn babies
    • Age 8 or younger
    • Women in their last half of pregnancy
    • Infants
  • Severe diarrhea
    • Using Vibramycin (doxycycline) for a long period of time
  • Sunburn or rash
    • Being in the sun for a long period of time
    • Using tanning salons
  • Harm to fetus (unborn baby)
    • Women who can potentially or want to become pregnant
    • Pregnant women
See more detailed risks and warnings
  • Tendon rupture and inflammation
    • People over age 60
    • Taking steroid medicine
    • Those with kidney, heart, or lung transplants
  • Myasthenia gravis
    • Those with a history of myasthenia gravis
  • Diarrhea
  • Nerve damage
  • Changes in mood and behavior
    • Those with a history of depression
  • Effects on heartbeat
    • Those with a history of heart rhythm problems
    • Taking other medicines that also affect your heart rhythm
    • Older people
See more detailed risks and warnings