Compare Doxycycline vs. Minocycline

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Vibramycin
(doxycycline)

Solodyn
(minocycline)

Treats bacterial infections. Vibramycin (Doxycycline) is good for treating many bacterial infections. It is also available as generic. However, it can make birth control pills less effective. You also have to protect yourself against sunburn.Treats bacterial infections. Solodyn (Minocycline) is an effective way to treat certain skin infections, acne, and rosacea, but you'll need to use barrier methods of birth control since it can make birth control pills less effective and cause birth defects.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.27Doxycycline
Reviews for Doxycycline
49%
of people (All ages) say Doxycycline is worth it
36%
say it works well
24%
say it's a big hassle
112 reviews
Have you used Vibramycin (doxycycline)?
Worth itNot sureNot worth it
Reviews for Minocycline
53%
-4% worse vs. Doxycycline
59%
-23% worse vs. Doxycycline
18%
-6% worse vs. Doxycycline
Have you used Solodyn (minocycline)?
Worth itNot sureNot worth it
Side effects
DoxycyclineMinocycline
  • Any adverse event 40%
  • Nausea 13%
  • Vomiting 8%
  • Diarrhea 3%
  • Bacterial vaginitis 3%
  • Headache 2%
  • Upper abdominal pain 2%
  • Vaginal yeast infection 2%
More Doxycycline side effects »

We haven’t found good data for Minocycline side effects.

FDA side effect reports for Minocycline »
How it works
DoxycyclineMinocycline
Vibramycin (Doxycycline) is a tetracycline antibiotic. It stops bacteria by preventing them from reproducing and repairing themselves.Solodyn (Minocycline) is a tetracycline antibiotic. It stops bacteria by preventing them from reproducing and repairing themselves.
Type of medication
DoxycyclineMinocycline
Prescription onlyPrescription only
Available as
DoxycyclineMinocycline
  • Pill
  • Delayed release capsule
  • Liquid
  • Pill
  • Extended release
  • Extended release capsule
Used for
DoxycyclineMinocycline
Risk factors for serious side effects
DoxycyclineMinocycline
  • Age 8 years or younger
  • Using oral birth control pills
  • Long antibiotic treatment period
  • Women of childbearing age
Detailed Vibramycin (doxycycline) risks & warnings »
  • Age 8 years or younger
  • Using oral birth control pills
  • Long antibiotic treatment period
  • Women of childbearing age
Detailed Solodyn (minocycline) risks & warnings »
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Price
DoxycyclineMinocycline
No price related info.
  • Available as a generic, so it should be reasonably priced.
Upsides and benefits
DoxycyclineMinocycline
  • Available in generic.
  • Available in different forms: tablet, capsule, and suspension.
  • Used to treat many types of bacterial infections.
  • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
  • Clinical studies show it's effective against MRSA, a common skin infection, and it's commonly used to treat acne and rosacea.
  • Available as a generic, so it should be reasonably priced.
  • Solodyn (Minocycline) is less likely to cause sunburn than other tetracycline antibiotics.
  • Bacteria are less likely to become resistant to Solodyn (Minocycline) than other tetracycline antibiotics.
Downsides and risks
DoxycyclineMinocycline
  • Can't be used in pregnant women and children under 8 years old.
  • Makes your skin more sensitive to the sun.
  • Has to be taken with plenty of water and food and you have to stay upright for 30 minutes afterwards to avoid stomach irritation.
  • Can make birth control less effective.
  • Can cause diarrhea.
  • It can make birth control pills less effective, so people should use barrier methods of birth control like condoms or diaphragms while on Solodyn (Minocycline).
  • Can stain your teeth, mouth, and gums if you're using the tablets, or your skin if you're using the topical version, but this is temporary.
Tips from our pharmacists for people taking the medication
DoxycyclineMinocycline
  • Take the medication exactly how your doctor tells you to.
  • If you're using birth control pills, this medication can make them less effective.
  • Wear sunblock if you have to go out into the sun since your skin can become more sensitive to sunburn.
  • Can cause diarrhea, nausea or vomiting.
  • Space out any vitamins by at least two hours.
  • Take with plenty of food and liquids.
  • Don't take any medications with bismuth (Pepto-Bismol, Kaopectate) while taking this medication.
  • Don't lie down for at least 30 minutes after taking this medication.
  • Both men and women should use barrier methods of birth control while on Solodyn (Minocycline) since it can cause birth defects and make birth control pills less effective.
  • Can make you dizzy, so be careful if you're getting up from lying down or sitting. Don't drive until you know how it affects you.
  • Can stain your teeth, tongue and gums, but this is temporary.
  • Take this exactly how your doctor or pharmacist tells you until it's all gone.
  • Don't eat any dairy products or take any vitamins within 2 hours of taking Solodyn (Minocycline) because they can make the medication less effective.
Learn more
More about DoxycyclineSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Vibramycin (doxycycline)?
Worth itNot sureNot worth it
More about MinocyclineSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Solodyn (minocycline)?
Worth itNot sureNot worth it