Compare doxycycline vs. Minocycline

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Vibramycin (doxycycline)

Prescription only

Solodyn (Minocycline)

Prescription only
Treats bacterial infections.

Vibramycin (doxycycline) is good for treating many bacterial infections, but can increase your skin's sensitivity to sunlight and make you more likely to get a sunburn or rash.

4.3/ 7 average rating with 112 reviewsfordoxycycline
Treats bacterial infections.

Solodyn (Minocycline) is an effective way to treat certain skin infections, acne, and rosacea, but you'll need to use barrier methods of birth control since it can make birth control pills less effective and cause birth defects.

5.5/ 7 average rating with 17 reviewsforMinocycline
Upsides
  • Vibramycin (doxycycline) is a good alternative for some types of bacterial infections for people who are allergic to penicillin.
  • Available in generic.
  • Available as a liquid for those who have trouble swallowing.
  • Vibramycin (doxycycline) is safe for people age 65 or older and those who have kidney problems.
  • Clinical studies show it's effective against MRSA, a common skin infection, and it's commonly used to treat acne and rosacea.
  • Available as a generic, so it should be reasonably priced.
  • Solodyn (Minocycline) is less likely to cause sunburn than other tetracycline antibiotics.
  • Bacteria are less likely to become resistant to Solodyn (Minocycline) than other tetracycline antibiotics.
Downsides
  • Vibramycin (doxycycline) makes your skin more sensitive to the sun.
  • Vibramycin (doxycycline) can make some birth control less effective, so you may have to use barrier methods (like condoms) while on it.
  • Vitamins, iron supplements, or antacids can't be taken at the same time as Vibramycin (doxycycline).
  • Vibramycin (doxycycline) can cause severe diarrhea that is usually watery and bloody, as late as up to 2 months after finishing the medicine.
  • It can make birth control pills less effective, so people should use barrier methods of birth control like condoms or diaphragms while on Solodyn (Minocycline).
  • Can stain your teeth, mouth, and gums if you're using the tablets, or your skin if you're using the topical version, but this is temporary.
Used for
Dosage forms
  • Pill
  • Delayed release pill
  • Liquid
  • Pill
  • Extended release
  • Extended release capsule
Price
Lowest price near you
$36.81
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Lowest price near you
$98.31
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Reviews
112 
49%
think this treatment is worth it
36%
think this treatment works well
24%
think this treatment is a hassle

Have you used Vibramycin (doxycycline)?

Leave a review
17 
53%
think this treatment is worth it
59%
think this treatment works well
18%
think this treatment is a hassle

Have you used Solodyn (Minocycline)?

Leave a review
Side effects
The Vibramycin (doxycycline) FDA package insert doesn’t have numbers about how common side effects are.
The Solodyn (Minocycline) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Color changes in teeth of young children and unborn babies

    Age 8 or younger

    ...and 2 more risk factors

  • Severe diarrhea

    Using Vibramycin (doxycycline) for a long period of time

  • Sunburn or rash

    Being in the sun for a long period of time

    ...and 1 more risk factors

  • Harm to fetus (unborn baby)

    Women who can potentially or want to become pregnant

    ...and 1 more risk factors

See more detailed risks and warnings
  • Changes in teeth

    Age 8 years or younger

  • Decreased effectiveness of birth control pills

    Using oral birth control pills

  • Diarrhea from a superinfection (an infection that happens after, or in addition to, an earlier infection)

    Long antibiotic treatment period

  • Harm to fetus

    Women of childbearing age

See more detailed risks and warnings