Compare Doxycycline vs. Renova

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Vibramycin
(Doxycycline)

Renova
(Tretinoin)

Treats bacterial infections. Vibramycin (Doxycycline) is good for treating many bacterial infections. It is also available as generic. However, it can make birth control pills less effective. You also have to protect yourself against sunburn.Treats acne and sun damage. Renova (Tretinoin) isn't a cure for fine lines and wrinkles, but it's clinically proven to improve them.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
No pricing data for this drug at this filter setting. Try searching onGoodRx
Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.223300970873787Doxycycline
Reviews for Vibramycin (Doxycycline)
50%
of people say Vibramycin (Doxycycline) is worth it
34%
say it works well
23%
say it's a big hassle
Reviews for Renova (Tretinoin)
40%
10% vs. Vibramycin (Doxycycline)
26%
8% vs. Vibramycin (Doxycycline)
28%
5% vs. Vibramycin (Doxycycline)
Side effects
DoxycyclineRenova

The Doxycycline FDA package insert doesn’t have numbers about how common side effects are.

More about Doxycycline side effects »
  • Severe local irritation 6%
More Renova side effects »
How it works
DoxycyclineRenova
Vibramycin (Doxycycline) is a tetracycline antibiotic. It stops bacteria by preventing them from reproducing and repairing themselves.Renova (Tretinoin) is a vitamin A derivative. Researchers don't know exactly how it works, but it seems to make skin cells renew faster and better.
Type of medication
DoxycyclineRenova
Antibiotic
Tetracycline
Prescription only
Acne agent
Retinoid
Prescription only
Available as
DoxycyclineRenova
  • Pill
  • Delayed release capsule
  • Liquid
  • Cream, gel, or ointment
Used for (click to learn more)
DoxycyclineRenova
Risk factors for serious side effects
DoxycyclineRenova
  • Age 8 years or younger
  • Using oral birth control pills
  • Long antibiotic treatment period
      • Women of childbearing age
      • Women of childbearing age
      • Overweight or obese
      • Taking isotretinoin (Accutane)
      Detailed Vibramycin (Doxycycline) risks & warnings »
      • Using other medicines or products that irritate the skin
      • Eczema
      • Extreme temperatures (hot or cold)
        • Allergy to fish or fish products
          Detailed Renova (Tretinoin) risks & warnings »
          Pregnancy category
          DoxycyclineRenova
          DFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          CFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          Alcohol
          No specific alcohol-related info.No specific alcohol-related info.
          Food
          • Has to be taken with plenty of water and food and you have to stay upright for 30 minutes afterwards to avoid stomach irritation.
          • Take with plenty of food and liquids.
          No specific food-related info.
          Kidneys and liver
          No specific kidneys and liver-related info.No specific kidneys and liver-related info.
          Sex
          No specific sex-related info.No specific sex-related info.
          Sleep
          No specific sleep-related info.No specific sleep-related info.
          Weight
          No specific weight-related info.No specific weight-related info.
          Upsides and benefits
          DoxycyclineRenova
          • Available in generic.
          • Available in different forms: tablet, capsule, and suspension.
          • Used to treat many types of bacterial infections.
          • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
          • You only need to apply it once a day, usually in the evening.
          • Most people who reported having skin irritation said that it was mild.
          • Part of a complete program to help you take better care of your skin.
          Downsides and risks
          DoxycyclineRenova
          • Can't be used in pregnant women and children under 8 years old.
          • Makes your skin more sensitive to the sun.
          • Has to be taken with plenty of water and food and you have to stay upright for 30 minutes afterwards to avoid stomach irritation.
          • Can make birth control less effective.
          • Can cause diarrhea.
          • It may take up to 6 months to see the full benefit for facial wrinkles.
          • Not a good choice for women who want to become or are pregnant
          • Can change the color and texture of your skin if used long-term.
          • You need to be careful about avoiding any sunlight or artificial tanning while using it.
          • It doesn't work for deep wrinkles.
          Tips from our pharmacists for people taking the medication
          DoxycyclineRenova
          • Take the medication exactly how your doctor tells you to.
          • If you're using birth control pills, this medication can make them less effective.
          • Wear sunblock if you have to go out into the sun since your skin can become more sensitive to sunburn.
          • Can cause diarrhea, nausea or vomiting.
          • Space out any vitamins by at least two hours.
          • Take with plenty of food and liquids.
          • Don't take any medications with bismuth (Pepto-Bismol, Kaopectate) while taking this medication.
          • Don't lie down for at least 30 minutes after taking this medication.
          • Works best as part of a complete skin care program (including SPF) to protect your skin from sun damage.
          • Renova doesn't permanently erase or improve significant skin changes such as deep wrinkles.
          • Apply a very small amount (pea-size) on entire face once a day at bedtime.
          • You'll need to use Renova regularly for at least 3 to 4 months before you see improvement. Once you stop, the improvement may slowly disappear.
          • Renova wasn't studied in people with skin cancer or serious damage from the sun (actinic keratosis) so it's not known if this would benefit.
          • Not safe to use during pregnancy. Even though Renova is applied to the skin, a small amount is absorbed and harmful to your unborn baby.
          • Some medicines you take by mouth can make you more sensitive to sunlight and combine with effects of Renova. Check with your doctor or pharmacist before you take any new medicines.
          Learn more
          More about DoxycyclineSide effectsReviews & ratingsAlternativesFDA package insert
          More about RenovaSide effectsReviews & ratingsFDA package insert