Compare doxycycline vs. Renova

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Vibramycin (doxycycline)

Prescription only

Renova (Tretinoin)

Prescription only
Treats bacterial infections.

Vibramycin (doxycycline) is good for treating many bacterial infections, but can increase your skin's sensitivity to sunlight and make you more likely to get a sunburn or rash.

4.3/ 7 average rating with 112 reviewsfordoxycycline
Treats acne and sun damage.

Renova (Tretinoin) isn't a cure for fine lines and wrinkles, but it's clinically proven to improve them.

4.2/ 7 average rating with 58 reviewsforRenova
Upsides
  • Vibramycin (doxycycline) is a good alternative for some types of bacterial infections for people who are allergic to penicillin.
  • Available in generic.
  • Available as a liquid for those who have trouble swallowing.
  • Vibramycin (doxycycline) is safe for people age 65 or older and those who have kidney problems.
  • You only need to apply it once a day, usually in the evening.
  • Most people who reported having skin irritation said that it was mild.
  • Part of a complete program to help you take better care of your skin.
Downsides
  • Vibramycin (doxycycline) makes your skin more sensitive to the sun.
  • Vibramycin (doxycycline) can make some birth control less effective, so you may have to use barrier methods (like condoms) while on it.
  • Vitamins, iron supplements, or antacids can't be taken at the same time as Vibramycin (doxycycline).
  • Vibramycin (doxycycline) can cause severe diarrhea that is usually watery and bloody, as late as up to 2 months after finishing the medicine.
  • It may take up to 6 months to see the full benefit for facial wrinkles.
  • Not a good choice for women who want to become or are pregnant
  • Can change the color and texture of your skin if used long-term.
  • You need to be careful about avoiding any sunlight or artificial tanning while using it.
  • It doesn't work for deep wrinkles.
Used for
Dosage forms
  • Pill
  • Delayed release pill
  • Liquid
  • Cream, gel, or ointment
Price
Lowest price near you
$36.81
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Lowest price near you
$68.4
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Reviews
112 
49%
think this treatment is worth it
36%
think this treatment works well
24%
think this treatment is a hassle

Have you used Vibramycin (doxycycline)?

Leave a review
58 
41%
think this treatment is worth it
28%
think this treatment works well
28%
think this treatment is a hassle

Have you used Renova (Tretinoin)?

Leave a review
Side effects
The Vibramycin (doxycycline) FDA package insert doesn’t have numbers about how common side effects are.
4possible side effects
  • Mild skin reactions
    100%
  • Severe local irritation
    7%
  • Any side effect
    4%
  • Skin hypo- or hyperpigmentation
    2%
See more detailed side effects
Risks and warnings
  • Color changes in teeth of young children and unborn babies

    Age 8 or younger

    ...and 2 more risk factors

  • Severe diarrhea

    Using Vibramycin (doxycycline) for a long period of time

  • Sunburn or rash

    Being in the sun for a long period of time

    ...and 1 more risk factors

  • Harm to fetus (unborn baby)

    Women who can potentially or want to become pregnant

    ...and 1 more risk factors

See more detailed risks and warnings
  • Skin irritation

    Using other medicines or products that irritate the skin

    ...and 2 more risk factors

  • Allergic reactions

    Allergy to fish or fish products

See more detailed risks and warnings