Compare Duetact vs. Kazano
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Duetact (pioglitazone / glimepiride) combines 2 different anti-diabetic medicines into one to help improve blood sugar control, but it is associated with serious complications such as heart failure.
Kazano (alogliptin / metformin) takes advantage of 2 medicines combined into one to lower your blood sugar, but you can develop tolerance if you have been taking this medication for a long time or at high doses.
- Taken only once a day.
- Effectively lowers A1c levels and greatly improves blood sugar control as a combination medicine compared to taking the 2 individual medicines alone.
- Duetact (pioglitazone / glimepiride) is a good add-on treatment option for people who are unable to fully control their blood sugar levels through diet and exercise alone.
- Duetact (pioglitazone / glimepiride) is an oral medicine so it might be a good alternative for those who don't like injections.
- Lowers A1c levels by 1.2-1.6%.
- Can be taken by mouth instead of using an injection.
- Less likely to cause weight gain and low blood sugar compared to other diabetes medications.
- Generic available, may be more affordable than others in it's class.
- Duetact (pioglitazone / glimepiride) might cause weight gain.
- Might not be a good treatment option for people with heart failure or liver problems.
- Might cause bone fractures, especially for women.
- Relatively expensive as a combination medicine compared to the 2 individual medicines alone.
- Not recommended for people age 65 or older and those with kidney problems because they are more likely to experience side effects such as low blood sugar.
- Rare but serious side effects include pancreatitis and severe joint pain.
- Tolerance can happen with Kazano (alogliptin / metformin) if you have been taking this drug for a long time or at high doses, it may not work as well and you may need higher doses to get the same effect.
- Heart failure and worsening heart failure has been linked to Kazano (alogliptin / metformin).
- The chance of low blood sugar may be raised when Kazano (alogliptin / metformin) is used with other medications for diabetes.
- Upper respiratory tract infection8%
- Common cold7%
- High blood pressure6%
- Back pain4%
- Urinary tract infection4%
- Fluid retention and heart failure
Those with a history of heart failure
- Low blood sugar
Skipping meals or having inconsistent meal times
...and 4 more risk factors
- Bone fractures
- Effect on liver function
Those with a history of liver problems
- Bladder cancer
Those with active bladder cancer or a history of it
- Danger from lactic acid build up (lactic acidosis)
...and 5 more risk factors
- inflammation of pancreas
History of pancreatitis
...and 3 more risk factors
- Heart failure
...and 2 more risk factors
- Liver problems
...and 1 more risk factors