Compare Duopa vs. Rytary

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Duopa
(carbidopa / levodopa)

Rytary
(carbidopa / levodopa)

Treats advanced stages of Parkinson's disease. Duopa (carbidopa / levodopa) pumps carbidopa/levodopa into your body throughout the day. It is reserved for advanced Parkinson's disease when your symptoms become more frequent than the dosing of your tablets.Treats Parkinson's disease. Rytary (carbidopa / levodopa) can be used to treat Parkinson's disease, but it can be expensive.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Duopa (carbidopa / levodopa)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Rytary (carbidopa / levodopa)?
Worth itNot sureNot worth it
Side effects
DuopaRytary
  • Problems with j-tube 56%
  • Nausea 30%
  • Constipation 22%
  • Redness and swelling at the j-tube site 19%
  • Difficulty controlling movements 14%
  • Low mood disorder 11%
  • Discharge at the j-tube site 11%
  • Swelling in the arms and legs 8%
  • High blood pressure 8%
  • Flu and cold 8%
More Duopa side effects »
  • Nausea 5%
  • Dizziness 4%
  • Dry mouth 2%
  • Abnormal dreams 2%
  • Difficulty controlling movements 2%
  • Anxiety 2%
  • Constipation 1%
More Rytary side effects »
How it works
DuopaRytary
Duopa (carbidopa / levodopa) is a combination of carbidopa and levodopa. Carbidopa allows levodopa to enter the brain and relieve symptoms of Parkinson's disease.Rytary (carbidopa / levodopa) is a combination of carbidopa and levodopa. Levodopa enters the brain and relieves the symptoms of Parkinson's disease. Carbidopa prevents levodopa from being broken down before it can enter the brain.
Type of medication
DuopaRytary
Prescription onlyPrescription only
Available as
DuopaRytary
  • Liquid
  • Extended release capsule
Used for
DuopaRytary
Risk factors for serious side effects
DuopaRytary
  • Surgery to place the J-tube
  • Taking other medicines for Parkinson's
  • Stopping Duopa (carbidopa / levodopa) suddenly
  • Taking other medicines for Parkinson's disease
Detailed Duopa (carbidopa / levodopa) risks & warnings »
  • Taking other medicines for Parkinson's disease
  • Stopping Rytary (carbidopa / levodopa) suddenly
  • History of heart attack
  • High risk for heart attack
Detailed Rytary (carbidopa / levodopa) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Pain
DuopaRytary
  • Call your doctor right away if you start having stomach pains around where the pump is connected.
No pain related info.
Sleep
DuopaRytary
  • Duopa (carbidopa / levodopa) can make you very sleepy. Don't drive or do anything that requires your full concentration until you know how Duopa (carbidopa / levodopa) affects you. You're more at risk if you're taking other medicines for Parkinson's. Talk to your doctor if this bothers you.
  • Duopa (carbidopa / levodopa) can make you very sleepy. Don't drive or do anything requiring concentration until you know how it affects you.
  • Rytary (carbidopa / levodopa) can make you sleepy or fall asleep suddenly without warning. Don't drive or do anything that requires concentration until you know how Rytary (carbidopa / levodopa) affects you. You're more at risk if you're taking other medicines for Parkinson's disease. Talk to your doctor if this bothers you.
Upsides and benefits
DuopaRytary
  • Duopa (carbidopa / levodopa) allows you to have better control of your symptoms than oral tablets, especially in later stages of Parkinson's disease.
  • Rytary (carbidopa / levodopa) comes in 4 different strengths.
  • If you have private prescription insurance, there are programs to make Rytary (carbidopa / levodopa) more affordable.
Downsides and risks
DuopaRytary
  • Given via pump so you'll need to have a procedure to attach the pump to your body.
  • You'll need to take good care of the pump so that it doesn't get disconnected or infected.
  • Duopa (carbidopa / levodopa) only lasts for 16 hours. You may need to take an extra dose of carbidopa/levodopa as tablet for nighttime control.
  • You need to keep Duopa (carbidopa / levodopa) in a fridge, but it should sit at room temperature 20 minutes before infusion.
  • There are other forms of Rytary (carbidopa / levodopa) that are generic and much cheaper.
  • Your doctor might have to change the dose of Rytary (carbidopa / levodopa) often before they find a dose that works for you.
  • Rytary (carbidopa / levodopa) can cause uncontrollable movements to happen, but this doesn't happen for 3 to 5 years.
  • Rytary (carbidopa / levodopa) is not a cure for Parkinson's disease; it can only slow the disease down.
Tips from our pharmacists for people taking the medication
DuopaRytary
  • Duopa (carbidopa / levodopa) is given via pump. You need to have a minor procedure to connect the pump to your body.
  • You may still need to take carbidopa/levodopa in tablet form at night or if the pump disconnects.
  • Call your doctor right away if you start having stomach pains around where the pump is connected.
  • Duopa (carbidopa / levodopa) is only good for 16 hours. Throw out the cassette when the infusion is done even if there's still medicine left inside.
  • Duopa (carbidopa / levodopa) can make you very sleepy. Don't drive or do anything requiring concentration until you know how it affects you.
  • Don't stop taking Duopa (carbidopa / levodopa) suddenly. It can be very dangerous. Talk to your doctor if you want to stop taking Duopa (carbidopa / levodopa).
  • If you can't swallow the capsules whole, they can be sprinkled on 1 to 2 tablespoons of applesauce. You have to take it right away.
  • Don't drive or do anything requiring concentration until you know how Rytary (carbidopa / levodopa) affects you.
  • You can't switch off other forms of carbidopa/levodopa to Rytary (carbidopa / levodopa) without talking to your doctor or pharmacist. They'll tell you how to do it safely.
Learn more
More about DuopaSide effectsAlternativesFDA package insert
Have you used Duopa (carbidopa / levodopa)?
Worth itNot sureNot worth it
More about RytarySide effectsAlternativesFDA package insert
Have you used Rytary (carbidopa / levodopa)?
Worth itNot sureNot worth it