Compare Edurant vs. Intelence

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Edurant
(rilpivirine)

Intelence
(etravirine)

Works with other medications to treat HIV infection. Edurant (rilpivirine) is a good HIV drug that has to be used in combination with other HIV medications in patients who are new to treatment or are looking for alternatives to a current HIV regimen.Works with other medicines to treat HIV infection. Intelence (etravirine) can be an option for patients who are already taking HIV medications but are in need of improving their current HIV drug regimen.
Reviews & ratings
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Have you used Edurant (rilpivirine)?
Worth itNot sureNot worth it

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Have you used Intelence (etravirine)?
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Side effects
EdurantIntelence
  • Depressive disorders 5%
  • Headache 3%
  • Insomnia 3%
  • Rash 3%
  • Abdominal pain 2%
  • Fatigue 2%
  • Abnormal dreams 2%
More Edurant side effects »
  • Skin rash 7%
  • Tingling in the arms & legs 2%
More Intelence side effects »
How it works
EdurantIntelence
Edurant (rilpivirine) is a Non-nucleoside reverse transcriptase inhibitor (NNRTI). It treats HIV by stopping the virus from replicating within cells in your immune system.Intelence (etravirine) is a Non-Nucleoside reverse transcriptase inhibitor (NNRTI). It treats HIV by stopping the virus from reproducing within cells in your immune system.
Type of medication
EdurantIntelence
Prescription onlyPrescription only
Available as
EdurantIntelence
  • Pill
  • Pill
Used for
EdurantIntelence
Risk factors for serious side effects
EdurantIntelence
  • History of mental health problems
  • Exposure to other infections
  • Start of a new HIV medication
  • Change in HIV therapy
  • Prior severe allergic reaction to Edurant (rilpivirine)
Detailed Edurant (rilpivirine) risks & warnings »
  • Use of Intelence (etravirine)
  • HIV treatment
  • HIV
  • Exposure to other infections
  • Start of a new HIV medication
Detailed Intelence (etravirine) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Food
EdurantIntelence
  • Take each dose with a meal.
  • Take after meals to increase drug absorption.
  • Should be taken after meals.
Kidneys and liver
EdurantIntelence
  • Can be used in patients with mild or moderate kidney damage.
  • Can be used in patients with kidney damage.
Upsides and benefits
EdurantIntelence
  • Generally well tolerated.
  • Taken only once daily.
  • Edurant (rilpivirine) is available in other combination tablets.
  • Can be used in patients with mild or moderate kidney damage.
  • Intelence (etravirine) has a lower rate of failure due to single HIV mutations compared to other HIV drugs in its class.
  • Can be used in patients with kidney damage.
  • If swallowing a tablet is difficult, you can dissolve Intelence (etravirine) in water and drink it.
  • Can used by children 6 years and older.
Downsides and risks
EdurantIntelence
  • Must be taken in combination with other HIV drugs to treat HIV. Cannot be taken alone as treatment.
  • Must be taken with a meal.
  • Cannot be taken with proton pump inhibitors (PPI) like Prilosec or Prevacid. If you need to take an acid reducer, try an antacid like calcium carbonate either 2 hours before or 4 hours after Edurant (rilpivirine). Drugs like Pepcid or Zantac (H2RAs) may also be an option, but these should be taken 12 hours before or 4 hours after Edurant (rilpivirine).
  • Not recommended for patients who have a significantly high level of viral cells or have a very low level of immune cells.
  • Not recommended for children under 12 years old.
  • Taken twice daily.
  • Should be taken after meals.
  • Not for use in patients who are new to HIV medications.
  • Intelence (etravirine) can interact with a significant number of drugs.
Tips from our pharmacists for people taking the medication
EdurantIntelence
  • Edurant (rilpivirine) should be taken at the same time everyday.
  • For missed doses, take one if you remember within 12 hours of your regularly scheduled time. Don't take two doses at the same time.
  • Take each dose with a meal.
  • Immediately report any signs of liver problems (jaundice, dark urine, yellowing of eyes, etc.) or sensitivity reactions (rash, fever, fatigue, difficulty breathing, etc.) to your doctor.
  • Take after meals to increase drug absorption.
  • If you’re unable to swallow tablets, try dispersing a tablet in at least a teaspoonful of water (enough to cover the tablet), stir well (until milky) and drink immediately.
  • Talk to your doctor or pharmacist before starting or stopping medications in order to prevent harmful interactions.
  • Always practice safe sex while taking Intelence (etravirine). Don't share needles or personal items that can have blood or body fluids on them.
  • Immediately report any signs of liver problems (jaundice, dark urine, yellowing of eyes, etc.) or sensitivity reactions (rash, fever, fatigue, difficulty breathing, etc.) to your doctor.
Learn more
More about EdurantSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Edurant (rilpivirine)?
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More about IntelenceSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Intelence (etravirine)?
Worth itNot sureNot worth it