Compare Effexor vs. Cafergot

Head-to-head comparisons of medication uses, side effects, ratings, and more.


(Ergotamine / Caffeine)

Improves mood and helps you relax. Effexor (Venlafaxine) is good for treating depression and anxiety. May work when other antidepressants haven't, it's but more likely to cause side effects and withdrawal symptoms than other antidepressants.Coming soon.
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Reviews & ratings
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Reviews for Effexor (Venlafaxine)
of people (All ages) say Effexor (Venlafaxine) is worth it
say it works well
say it's a big hassle
577 reviews
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Have you used Cafergot (Ergotamine / Caffeine)?
Worth itNot sureNot worth it
Side effects
  • Nausea 24%
  • Dizziness 19%
  • Sleep difficulty 10%
  • Drowsiness 14%
  • Muscle weakness 12%
  • Loss of appetite 12%
  • Nervousness 10%
  • Sweating 7%
  • Abnormality of accommodation 8%
  • Indigestion 5%
More Effexor side effects »

We haven’t found good data for Cafergot side effects.

FDA side effect reports for Cafergot »
How it works
Effexor (Venlafaxine) is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant. It increases serotonin and norepinephrine activity in the brain, which regulate mood.Coming soon.
Type of medication
Prescription only
Available as
  • Pill
  • Extended release
  • Pill
  • Suppository
Used for
  • Migraine Vascular Headache
Risk factors for serious side effects
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Effexor (Venlafaxine) suddenly
  • History of high blood pressure
  • Taking other blood-thinning drugs
    • History of bipolar disorder
    • At risk for bipolar disorder
    Detailed Effexor (Venlafaxine) risks & warnings »
    Coming soon.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
    No sex related info.
    Upsides and benefits
    • Effective at relieving depression and anxiety symptoms.
    • Lowers relapse rates of depression.
    • Causes more sleepiness than other antidepressants, so it's good for people who have trouble sleeping.
    • Six out of ten people who use an antidepressant for the first time find that it works for them.
    • Might work when other antidepressants haven't worked since it affects two chemicals in the brain that impact your mood. Many other antidepressants affect only serotonin, but not norepinephrine too.
    Coming soon
    Downsides and risks
    • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
    • Not the best option for people with high blood pressure.
    • Overdosing on this medication could be fatal.
    • It's more likely to cause nausea and vomiting or make you feel sick if you miss a dose than other antidepressants. Also causes more sleepiness than others.
    • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
    • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
    Coming soon
    Tips from our pharmacists for people taking the medication
    • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
    • You can take the extended-release form once a day with food either in the morning or in the evening at about the same time each day.
    • Extended-release capsules should be swallowed whole. If you can’t swallow pills, open the capsule, sprinkle it on a spoonful of applesauce and then swallow it without chewing.
    • Stop taking it slowly to avoid getting withdrawal symptoms.
    • Tell your doctor if you notice sudden mood changes or unusual thoughts.
    Coming soon
    Learn more
    More about EffexorSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Effexor (Venlafaxine)?
    Worth itNot sureNot worth it
    More about CafergotSide effectsFDA package insert
    Have you used Cafergot (Ergotamine / Caffeine)?
    Worth itNot sureNot worth it