Compare Effexor vs. Klonopin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Effexor
(venlafaxine)

Klonopin
(clonazepam)

Improves mood and helps you relax. Effexor (Venlafaxine) is good for treating depression and anxiety. It may work when other antidepressants haven't, but it's more likely to cause side effects and withdrawal symptoms than other antidepressants.Controls seizures and helps you relax. Klonopin (Clonazepam) is okay for occasional or short-term use (up to 4 weeks) for anxiety, and to treat seizures. Less severe withdrawal symptoms compared to similar drugs.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.07Effexor
Reviews for Effexor
62%
of people (All ages) say Effexor is worth it
51%
say it works well
23%
say it's a big hassle
577 reviews
Have you used Effexor (venlafaxine)?
Worth itNot sureNot worth it
Reviews for Klonopin
70%
-8% worse vs. Effexor
52%
-1% worse vs. Effexor
14%
-9% worse vs. Effexor
767 reviews
Have you used Klonopin (clonazepam)?
Worth itNot sureNot worth it
Side effects
EffexorKlonopin
  • Nausea 26%
  • Headache 1%
  • Somnolence 14%
  • Dry mouth 11%
  • Dizziness 11%
  • Insomnia 8%
  • Abnormal Ejaculation 16%
  • Constipation 8%
  • Nervousness 17%
  • Asthenia 14%
More Effexor side effects »
  • Drowsiness 50%
  • Ataxia 30%
  • Behavior problems 25%
  • Somnolence 16%
  • Upper Respiratory Tract Infection 6%
  • Fatigue 5%
  • Depression 6%
  • Dizziness 1%
  • Colpitis 3%
  • Sinusitis 1%
More Klonopin side effects »
How it works
EffexorKlonopin
Effexor (Venlafaxine) is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant. It increases serotonin and norepinephrine activity in the brain, which regulate mood.Klonopin (Clonazepam) is a fast-acting benzodiazepine. It affects neurotransmitters in the brain and calms the nervous system. This reduces anxiety and muscle spasms, and causes sleepiness.
Type of medication
EffexorKlonopin
Prescription onlyPrescription only
Available as
EffexorKlonopin
  • Pill
  • Extended release
  • Pill
  • Dissolving tablet
Used for
EffexorKlonopin
Risk factors for serious side effects
EffexorKlonopin
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Effexor (Venlafaxine) suddenly
  • History of high blood pressure
  • Taking other blood-thinning drugs
Detailed Effexor (venlafaxine) risks & warnings »
  • Taking more than the prescribed dose
  • Taking longer than 4 weeks
  • History of drug abuse
  • Long-term use
  • Alcohol
Detailed Klonopin (clonazepam) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
EffexorKlonopin
No alcohol related info.
  • Not safe to use with alcohol.
  • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
Sex
EffexorKlonopin
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
No sex related info.
Sleep
EffexorKlonopin
No sleep related info.
  • Can cause dizziness, drowsiness, and salivation.
  • Can cause memory problems, drowsiness, dizziness, and confusion.
Upsides and benefits
EffexorKlonopin
  • Effective at relieving depression and anxiety symptoms.
  • Lowers relapse rates of depression.
  • Causes more sleepiness than other antidepressants, so it's good for people who have trouble sleeping.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
  • Might work when other antidepressants haven't worked since it affects two chemicals in the brain that impact your mood. Many other antidepressants affect only serotonin, but not norepinephrine too.
  • Effective at relieving short-term anxiety and sleeplessness.
  • Can be used together with antidepressants to manage anxiety disorders. Especially helpful for anxiety symptoms while you wait for an antidepressant to kick in (it can take several weeks).
  • Can be used alone or with other medicines to treat seizures.
  • Less severe withdrawal symptoms compared to other benzodiazepines.
Downsides and risks
EffexorKlonopin
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
  • Not the best option for people with high blood pressure.
  • Overdosing on this medication could be fatal.
  • It's more likely to cause nausea and vomiting or make you feel sick if you miss a dose than other antidepressants. Also causes more sleepiness than others.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
  • Can cause memory problems, drowsiness, dizziness, and confusion.
  • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
  • Most people find that it gets less effective over time.
Tips from our pharmacists for people taking the medication
EffexorKlonopin
  • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
  • You can take the extended-release form once a day with food either in the morning or in the evening at about the same time each day.
  • Extended-release capsules should be swallowed whole. If you can’t swallow pills, open the capsule, sprinkle it on a spoonful of applesauce and then swallow it without chewing.
  • Stop taking it slowly to avoid getting withdrawal symptoms.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • For the first week, avoid activities that require you to be alert.
  • Can cause dizziness, drowsiness, and salivation.
  • Report any confusion or inability to control muscle movements to your doctor.
  • Not safe to use with alcohol.
Learn more
More about EffexorSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Effexor (venlafaxine)?
Worth itNot sureNot worth it
More about KlonopinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Klonopin (clonazepam)?
Worth itNot sureNot worth it