Compare Effexor vs. Maxalt

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Effexor
(Venlafaxine)

Maxalt
(Rizatriptan)

Improves mood and helps you relax. Effexor (Venlafaxine) is good for treating depression and anxiety. May work when other antidepressants haven't, it's but more likely to cause side effects and withdrawal symptoms than other antidepressants.Treats migraine headaches. Maxalt (Rizatriptan) is great for relieving short migraines, but doesn't work as well for long-lasting headaches.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.041304347826087Effexor
Reviews for Effexor (Venlafaxine)
61%
of people say Effexor (Venlafaxine) is worth it
50%
say it works well
22%
say it's a big hassle

Not enough reviews for this drug. Help someone out, leave a review!

Side effects
EffexorMaxalt
  • Nausea 42%
  • Drowsiness 22%
  • Dizziness 20%
  • Nervousness 17%
  • Sleep difficulty 16%
  • Loss of appetite 15%
  • Sweating 14%
  • Dry mouth 13%
  • Dry mouth 11%
  • Muscle weakness 10%
More Effexor side effects »

We haven’t found good data for Maxalt side effects.

FDA side effect reports for Maxalt »
How it works
EffexorMaxalt
Effexor (Venlafaxine) is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant. It increases serotonin and norepinephrine activity in the brain, which regulate mood.Maxalt (Rizatriptan) is a triptan medication that treats migraine headaches. It releases serotonin, which lowers the inflammation that causes headaches.
Type of medication
EffexorMaxalt
Antidepressant
Serotonin-norepinephrine reuptake inhibitor (SNRI)
Prescription only
Antimigraine
Triptan
Prescription only
Available as
EffexorMaxalt
  • Pill
  • Extended release
  • Pill
  • Dissolving tablet
Used for (click to learn more)
EffexorMaxalt
How well it works for depression
The free Iodine Start program helps people track how well they are improving, and find the right antidepressant faster.

After 4 weeks using Start and Effexor (Venlafaxine), here’s how much better people feel.

The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Maxalt (Rizatriptan)
Risk factors for serious side effects
EffexorMaxalt
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Effexor (Venlafaxine) suddenly
  • History of high blood pressure
  • Taking other blood-thinning drugs
    • History of bipolar disorder
    • At risk for bipolar disorder
    Detailed Effexor (Venlafaxine) risks & warnings »
    • History of heart problems
    • High blood pressure
    • High cholesterol
    • Diabetes
    • Being overweight or obese
    • Smoking
    • History of heart problems
    • High blood pressure
    • High cholesterol
    • Diabetes
    • Being overweight or obese
    • Smoking
      • Patients taking SSRIs and SNRIs
      • History of high blood pressure
      • History of seizures
      • Phenylketonuria (PKU)
      Detailed Maxalt (Rizatriptan) risks & warnings »
      Pregnancy category
      EffexorMaxalt
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      Alcohol
      No specific alcohol-related info.No specific alcohol-related info.
      Food
      • You can take the extended-release form once a day with food either in the morning or in the evening at about the same time each day.
      No specific food-related info.
      Kidneys and liver
      No specific kidneys and liver-related info.No specific kidneys and liver-related info.
      Sex
      • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
      • Effexor (Venlafaxine) can cause lower sex drive or difficulty having an orgasm. If the problem persists after the first 2 to 3 months, you can talk to your doctor about alternative antidepressants or performance-enhancing medications.
      No specific sex-related info.
      Sleep
      • Causes more sleepiness than other antidepressants, so it's good for people who have trouble sleeping.
      • Stopping Effexor (Venlafaxine) suddenly may cause withdrawal symptoms such as nausea, anxiety, agitation, flu-like symptoms, trouble sleeping, and dizziness. Withdrawal symptoms usually occur within 3 days of stopping the medication, and go away within 1 to 2 weeks. Work with your doctor to gradually reduce your dose.
      No specific sleep-related info.
      Weight
      No specific weight-related info.No specific weight-related info.
      Upsides and benefits
      EffexorMaxalt
      • Effective at relieving depression and anxiety symptoms.
      • Lowers relapse rates of depression.
      • Causes more sleepiness than other antidepressants, so it's good for people who have trouble sleeping.
      • Six out of ten people who use an antidepressant for the first time find that it works for them.
      • Might work when other antidepressants haven't worked since it affects two chemicals in the brain that impact your mood. Many other antidepressants affect only serotonin, but not norepinephrine too.
      • Triptans like Maxalt (Rizatriptan) are considered the first-choice treatment to relieve moderate to severe migraine-type headaches.
      • It can also be used to treat tension-type headaches.
      • Not all triptans work the same way for people, so you can try multiple ones to find the right medication for you.
      • You don't need to drink water with the orally disintegrating tablet for it to work, so this could be a good medication for people who can't keep water down when they have a migraine.
      Downsides and risks
      EffexorMaxalt
      • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
      • Not the best option for people with high blood pressure.
      • Overdosing on this medication could be fatal.
      • It's more likely to cause nausea and vomiting or make you feel sick if you miss a dose than other antidepressants. Also causes more sleepiness than others.
      • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
      • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
      • Maxalt (Rizatriptan) doesn’t prevent migraines or tension headaches, but only works once the headache starts.
      • It can cause rebound headaches if it’s used too often.
      • You need to wait at least 2 hours after your first dose to take a second dose.
      • May not be the best choice if you have long, drawn-out headaches. Ask your doctor about other triptans that can last longer than Maxalt (Rizatriptan).
      • Not a good choice if you have heart disease or if you’re pregnant or breast-feeding.
      Tips from our pharmacists for people taking the medication
      EffexorMaxalt
      • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
      • You can take the extended-release form once a day with food either in the morning or in the evening at about the same time each day.
      • Extended-release capsules should be swallowed whole. If you can’t swallow pills, open the capsule, sprinkle it on a spoonful of applesauce and then swallow it without chewing.
      • Stop taking it slowly to avoid getting withdrawal symptoms.
      • Tell your doctor if you notice sudden mood changes or unusual thoughts.
      • Take Maxalt (Rizatriptan) as soon as you feel you’re getting a headache or experience warning signs like being sensitive to light or sound.
      • If you're taking other medicines to control your headaches (like propranolol), the dose of Maxalt (Rizatriptan) will be different.
      • Let your doctor know if your headaches don’t go away after taking [name-common] or if you have more than 4 migraines per month.
      • It’s available in two different dosage forms, a tablet you take by mouth and an orally disintegrating tablet (Maxalt-MLT) you place on your tongue to let it dissolve.
      • Lie down in a dark room after taking Maxalt (Rizatriptan) to help ease pain. Ask your doctor about other medicines that can help prevent your headaches.
      Learn more
      More about EffexorSide effectsReviews & ratingsAlternativesFDA package insert
      More about MaxaltSide effectsReviews & ratingsAlternativesFDA package insert