Compare Effexor vs. Oleptro

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Effexor
(venlafaxine)

Oleptro
(trazodone)

Improves mood and helps you relax. Effexor (Venlafaxine) is good for treating depression and anxiety. May work when other antidepressants haven't, it's but more likely to cause side effects and withdrawal symptoms than other antidepressants.Improves mood and helps you sleep. Oleptro (Trazodone) works well as a sleep aid, but has more side effects when used at higher doses for treating depression.
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Prices and coupon for 60 (75mg) tablets of venlafaxine
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Prices and coupon for 30 (50mg) tablets of trazodone
Reviews & ratings
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Filter group. All currently selected
5.07Effexor
Reviews for Effexor (venlafaxine)
62%
of people (All ages) say Effexor (venlafaxine) is worth it
51%
say it works well
23%
say it's a big hassle
577 reviews
Have you used Effexor (venlafaxine)?
Worth itNot sureNot worth it
Reviews for Oleptro (trazodone)
73%
+11% better vs. Effexor (venlafaxine)
49%
-2% worse vs. Effexor (venlafaxine)
24%
-1% worse vs. Effexor (venlafaxine)
Have you used Oleptro (trazodone)?
Worth itNot sureNot worth it
Side effects
EffexorOleptro
  • Nausea 24%
  • Dizziness 19%
  • Sleep difficulty 10%
  • Drowsiness 14%
  • Muscle weakness 12%
  • Loss of appetite 12%
  • Nervousness 10%
  • Sweating 7%
  • Abnormality of accommodation 8%
  • Indigestion 5%
More Effexor side effects »
  • Somnolence/sedation 27%
  • Drowsiness 21%
  • Dry mouth 14%
  • Headache 6%
  • Dizziness/lightheadedness 13%
  • Dizziness 13%
  • Nausea 8%
  • Fatigue 7%
More Oleptro side effects »
How it works
EffexorOleptro
Effexor (Venlafaxine) is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant. It increases serotonin and norepinephrine activity in the brain, which regulate mood.Oleptro (Trazodone) is a serotonin reuptake inhibitor (SRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.
Type of medication
EffexorOleptro
Prescription only
Prescription only
Available as
EffexorOleptro
  • Pill
  • Extended release
  • Pill
  • Extended release
Used for
EffexorOleptro
Risk factors for serious side effects
EffexorOleptro
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Effexor (Venlafaxine) suddenly
  • History of high blood pressure
  • Taking other blood-thinning drugs
    • History of bipolar disorder
    • At risk for bipolar disorder
    Detailed Effexor (venlafaxine) risks & warnings »
    • Age 24 years or younger
    • History of seizures
    • Alcoholism
    • Eating disorder
    • Higher dose
    • Drug interactions
      • Age 65 years or older
      • Alcohol
      • Taking other medicines that make you less alert
      Detailed Oleptro (trazodone) risks & warnings »
      Pregnancy

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Sex
      EffexorOleptro
      • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
      No sex related info.
      Upsides and benefits
      EffexorOleptro
      • Effective at relieving depression and anxiety symptoms.
      • Lowers relapse rates of depression.
      • Causes more sleepiness than other antidepressants, so it's good for people who have trouble sleeping.
      • Six out of ten people who use an antidepressant for the first time find that it works for them.
      • Might work when other antidepressants haven't worked since it affects two chemicals in the brain that impact your mood. Many other antidepressants affect only serotonin, but not norepinephrine too.
      • Commonly used in lower doses to help treat sleep problems (insomnia).
      • Safer sleep medication than others (benzodiazepines or Unisom) for people age 65 and older.
      • Fewer sexual side effects than many other antidepressants.
      • Has been used for sleep and depression for a long time. There's a lot of information available about how it works and how safe it is.
      • Comes as a generic medication and is cheaper than many other sleep aides.
      • Six out of ten people who use an antidepressant for the first time find that it works for them.
      Downsides and risks
      EffexorOleptro
      • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
      • Not the best option for people with high blood pressure.
      • Overdosing on this medication could be fatal.
      • It's more likely to cause nausea and vomiting or make you feel sick if you miss a dose than other antidepressants. Also causes more sleepiness than others.
      • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
      • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
      • Not as effective as other medications for depression.
      • More sedating than other antidepressants.
      • Causes more side effects when used at higher doses for depression. Includes sleepiness, dizziness, upset stomach, and irregular heartbeat.
      • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
      • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
      Tips from our pharmacists for people taking the medication
      EffexorOleptro
      • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
      • You can take the extended-release form once a day with food either in the morning or in the evening at about the same time each day.
      • Extended-release capsules should be swallowed whole. If you can’t swallow pills, open the capsule, sprinkle it on a spoonful of applesauce and then swallow it without chewing.
      • Stop taking it slowly to avoid getting withdrawal symptoms.
      • Tell your doctor if you notice sudden mood changes or unusual thoughts.
      • Makes you sleepy. Take at bedtime.
      • Can cause temporary dry mouth and upset stomach.
      • Seek medical attention for unwanted, persistent erection.
      • Tell your doctor if you notice sudden mood changes or unusual thoughts.
      Learn more
      More about EffexorSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Effexor (venlafaxine)?
      Worth itNot sureNot worth it
      More about OleptroSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Oleptro (trazodone)?
      Worth itNot sureNot worth it