Compare Effexor vs. nefazodone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Effexor
(Venlafaxine)

nefazodone

Improves mood and helps you relax. Effexor (Venlafaxine) is good for treating depression and anxiety. It may work when other antidepressants haven't, but it's more likely to cause side effects and withdrawal symptoms than other antidepressants.Treats depression. Serzone (nefazodone) is usually used with other medicines to treat depression, but it is more likely to cause liver damage.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.07Effexor
Reviews for Effexor
62%
of people (All ages) say Effexor is worth it
51%
say it works well
23%
say it's a big hassle
577 reviews
Have you used Effexor (Venlafaxine)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Serzone (nefazodone)?
Worth itNot sureNot worth it
Side effects
Effexornefazodone
  • Chest pain 1%
  • Trauma 1%
  • Pressure/hypertension 2%
  • Tachycardia 2%
  • Libido decreased 2%
  • Agitation 2%
  • Confusion 1%
  • Thinking abnormal 1%
  • Taste perversion 2%
  • Tinnitus 2%
More Effexor side effects »
  • Chills 1%
  • Fever 1%
  • Low blood pressure 1%
  • Itching 1%
  • Skin rashes 1%
  • Nausea and vomiting 1%
  • Trouble controlling movements 2%
  • Coordination problems 1%
  • Slowing of movement or speech 1%
  • Tremor 1%
More nefazodone side effects »
How it works
Effexornefazodone
Effexor (Venlafaxine) is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant. It increases serotonin and norepinephrine activity in the brain, which regulate mood.Serzone (nefazodone) is a serotonin reuptake inhibitor. Serzone (nefazodone) raises the amount of serotonin in the brain, which helps to regulate your mood.
Type of medication
Effexornefazodone
Prescription onlyLower-cost generic availablePrescription onlyLower-cost generic available
Available as
Effexornefazodone
  • Pill
  • Extended release
  • Pill
Used for
Effexornefazodone
Risk factors for serious side effects
Effexornefazodone
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Effexor (Venlafaxine) suddenly
  • History of high blood pressure
  • Taking other blood-thinning drugs
Detailed Effexor (Venlafaxine) risks & warnings »
  • People under age 24
  • Taking medicine for high blood pressure
  • History of seizures
  • History of heart attack or heart disease
  • Medicines that slow the heartbeat
Detailed Serzone (nefazodone) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
Effexornefazodone
No interactions related info.
  • Compared to other similar medicines, Serzone (nefazodone) has a lot of interactions with other drugs, so your doctor might have to adjust the doses of your other medicines.
Pain
Effexornefazodone
No pain related info.
  • Talk to your doctor right away if you notice yellowing in the whites of your eyes or your skin, a high fever, pain in your stomach, or dark urine.
Sex
Effexornefazodone
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
No sex related info.
Upsides and benefits
Effexornefazodone
  • Effective at relieving depression and anxiety symptoms.
  • Lowers relapse rates of depression.
  • Causes more sleepiness than other antidepressants, so it's good for people who have trouble sleeping.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
  • Might work when other antidepressants haven't worked since it affects two chemicals in the brain that impact your mood. Many other antidepressants affect only serotonin, but not norepinephrine too.
  • Serzone (nefazodone) is a good choice to take with other medicines for depression if they haven't worked by themselves.
  • Serzone (nefazodone) is available in generic.
Downsides and risks
Effexornefazodone
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
  • Not the best option for people with high blood pressure.
  • Overdosing on this medication could be fatal.
  • It's more likely to cause nausea and vomiting or make you feel sick if you miss a dose than other antidepressants. Also causes more sleepiness than others.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
  • While Serzone (nefazodone) is available as a generic, it's not considered a first or second choice medicine for depression because it is more likely to cause liver damage than other similar medicines.
  • Serzone (nefazodone) is usually taken 2 times a day; the first choice medicines are only taken 1 time a day.
  • It can take up to 3 months before you notice the full effects of Serzone (nefazodone).
  • Compared to other similar medicines, Serzone (nefazodone) has a lot of interactions with other drugs, so your doctor might have to adjust the doses of your other medicines.
Tips from our pharmacists for people taking the medication
Effexornefazodone
  • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
  • You can take the extended-release form once a day with food either in the morning or in the evening at about the same time each day.
  • Extended-release capsules should be swallowed whole. If you can’t swallow pills, open the capsule, sprinkle it on a spoonful of applesauce and then swallow it without chewing.
  • Stop taking it slowly to avoid getting withdrawal symptoms.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • You may not notice any changes in your mood until you've taken Serzone (nefazodone) for at least 2 weeks. The full effects may not happen for at least 2 to 3 months.
  • Don't drive or do anything requiring concentration until you know how Serzone (nefazodone) affects you because it can make you feel dizzy.
  • If you forget a dose of Serzone (nefazodone), take it as soon as you remember. If it's time for your next dose, don't take 2 doses at the same time to make up for the missed dose.
  • Store Serzone (nefazodone) in your pantry away from heat, light, and moisture.
  • Talk to your doctor right away if you notice yellowing in the whites of your eyes or your skin, a high fever, pain in your stomach, or dark urine.
Learn more
More about EffexorSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Effexor (Venlafaxine)?
Worth itNot sureNot worth it
More about nefazodoneSide effectsAlternativesFDA package insert
Have you used Serzone (nefazodone)?
Worth itNot sureNot worth it