Compare Effexor vs. Zoloft

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Effexor
(Venlafaxine)

Zoloft
(Sertraline)

Improves mood and helps you relax. Effexor (Venlafaxine) is good for treating depression and anxiety. May work when other antidepressants haven't, it's but more likely to cause side effects and withdrawal symptoms than other antidepressants.Improves mood and helps you relax. Zoloft (Sertraline) is good for treating depression and anxiety. It's more likely to cause insomnia and diarrhea than other antidepressants.
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Reviews & ratings
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5.041304347826087Effexor
Reviews for Effexor (Venlafaxine)
61%
of people (All ages) say Effexor (Venlafaxine) is worth it
50%
say it works well
22%
say it's a big hassle
460 reviews
Have you used Effexor (Venlafaxine)?
Worth itNot sureNot worth it
Reviews for Zoloft (Sertraline)
59%
2% vs. Effexor (Venlafaxine)
40%
10% vs. Effexor (Venlafaxine)
15%
+7% vs. Effexor (Venlafaxine)
1299 reviews
Have you used Zoloft (Sertraline)?
Worth itNot sureNot worth it
Side effects
EffexorZoloft
  • Nausea 42%
  • Drowsiness 22%
  • Dizziness 20%
  • Nervousness 17%
  • Sleep difficulty 16%
  • Loss of appetite 15%
  • Sweating 14%
  • Dry mouth 13%
  • Dry mouth 11%
  • Muscle weakness 10%
More Effexor side effects »
  • Nausea 19%
  • Ejaculation failure 18%
  • Sleep difficulty 16%
  • Diarrhea/loose stools 14%
  • Fatigue 9%
  • Loss of appetite 9%
  • Lower sex drive 9%
  • Sweating increased 9%
  • Dizziness 8%
  • Indigestion 8%
More Zoloft side effects »
How it works
EffexorZoloft
Effexor (Venlafaxine) is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant. It increases serotonin and norepinephrine activity in the brain, which regulate mood.Zoloft (Sertraline) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases the activity of serotonin in the brain, which regulates mood.
Type of medication
EffexorZoloft
Antidepressant
Serotonin-norepinephrine reuptake inhibitor (SNRI)
Prescription only
Antidepressant
Selective serotonin reuptake inhibitor (SSRI)
Prescription only
Available as
EffexorZoloft
  • Pill
  • Extended release
  • Pill
  • Liquid
Used for (click to learn more)
EffexorZoloft
Risk factors for serious side effects
EffexorZoloft
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Effexor (Venlafaxine) suddenly
  • History of high blood pressure
  • Taking other blood-thinning drugs
    • History of bipolar disorder
    • At risk for bipolar disorder
    Detailed Effexor (Venlafaxine) risks & warnings »
    • Under 24 years old
    • Interactions with other medications
        • Stopping Zoloft (Sertraline) suddenly
        • Taking with blood-thinning drugs
        • Elderly
        • Taking with diuretic medications
        Detailed Zoloft (Sertraline) risks & warnings »
        Pregnancy

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Interactions
        EffexorZoloft
        No interactions related info.
        • It interacts with St. John's Wort and Tryptophan.
        Sex
        EffexorZoloft
        • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
        • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
        Sleep
        EffexorZoloft
        No sleep related info.
        • Causes less drowsiness than other antidepressants.
        • Zoloft (Sertraline) may increase the risk of low sodium levels in the blood (hyponatremia). Watch out for symptoms including headache, difficulty concentrating, memory problems, confusion, weakness, and unsteadiness, which may lead to falls. Talk to a doctor right away before developing more serious symptoms, such as hallucination, fainting, coma, and death.
        Upsides and benefits
        EffexorZoloft
        • Effective at relieving depression and anxiety symptoms.
        • Lowers relapse rates of depression.
        • Causes more sleepiness than other antidepressants, so it's good for people who have trouble sleeping.
        • Might work when other antidepressants haven't worked since it affects two chemicals in the brain that impact your mood. Many other antidepressants affect only serotonin, but not norepinephrine too.
        • Six out of ten people who use an antidepressant for the first time find that it works for them.
        • Effective at lowering symptoms and relapse rates of depression and anxiety disorders.
        • Causes less drowsiness than other antidepressants.
        • Six out of ten people who use an antidepressant for the first time find that it works for them.
        Downsides and risks
        EffexorZoloft
        • Not the best option for people with high blood pressure.
        • Overdosing on this medication could be fatal.
        • It's more likely to cause nausea and vomiting or make you feel sick if you miss a dose than other antidepressants. Also causes more sleepiness than others.
        • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
        • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
        • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
        • More likely to cause diarrhea than other antidepressants.
        • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
        • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
        • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
        Tips from our pharmacists for people taking the medication
        EffexorZoloft
        • You can take the extended-release form once a day with food either in the morning or in the evening at about the same time each day.
        • Extended-release capsules should be swallowed whole. If you can’t swallow pills, open the capsule, sprinkle it on a spoonful of applesauce and then swallow it without chewing.
        • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
        • Stop taking it slowly to avoid getting withdrawal symptoms.
        • Tell your doctor if you notice sudden mood changes or unusual thoughts.
        • It interacts with St. John's Wort and Tryptophan.
        • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
        • Stop taking it slowly to avoid getting withdrawal symptoms.
        • Tell your doctor if you notice sudden mood changes or unusual thoughts.
        Learn more
        More about EffexorSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Effexor (Venlafaxine)?
        Worth itNot sureNot worth it
        More about ZoloftSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Zoloft (Sertraline)?
        Worth itNot sureNot worth it