Compare Elavil vs. amoxapine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Elavil
(amitriptyline)

Asendin
(amoxapine)

Improves mood and relieves certain kinds of pain. Elavil (Amitriptyline) is an older antidepressant that's sometimes used to treat pain and sleep problems, but it can have more side effects than similar medications.Stabilizes your mood. While Asendin (amoxapine) can treat depression, you have to take it several times a day and it can make you feel sleepy.
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Coupons for Elavil
Best available price for 30 (25mg) tablets of amitriptyline
Coupons for amoxapine
Best available price for 30 (50mg) tablets of amoxapine
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.48Elavil
Reviews for Elavil (amitriptyline)
53%
of people (All ages) say Elavil (amitriptyline) is worth it
36%
say it works well
25%
say it's a big hassle
134 reviews
Have you used Elavil (amitriptyline)?
Worth itNot sureNot worth it
Reviews for Asendin (amoxapine)
Not enough review data. Review it!
-53% worse vs. Elavil (amitriptyline)
Not enough review data. Review it!
-36% worse vs. Elavil (amitriptyline)
Not enough review data. Review it!
-75% worse vs. Elavil (amitriptyline)
Have you used Asendin (amoxapine)?
Worth itNot sureNot worth it
Side effects
Elavilamoxapine

The Elavil FDA package insert doesn’t have numbers about how common side effects are.

More about Elavil side effects »
  • Drowsiness or fatigue 14%
  • Dry mouth 14%
  • Constipation 12%
  • Vision changes 7%
More amoxapine side effects »
How it works
Elavilamoxapine
Elavil (Amitriptyline) is a tricyclic antidepressant (TCA). Researchers don't know exactly how it works. It may change serotonin and norepinephrine activity in the brain, which regulates mood and pain perception. It also has sedative effects.Asendin (amoxapine) is a tricyclic antidepressant. It increases the activity of serotonin and norepinephrine in your brain which regulate your mood.
Type of medication
Elavilamoxapine
Prescription only
Prescription only
Available as
Elavilamoxapine
  • Pill
  • Pill
Used for
Elavilamoxapine
Risk factors for serious side effects
Elavilamoxapine
  • Age 24 years or younger
  • History of bipolar disorder
  • At risk for bipolar disorder
  • History of cardiovascular disease
  • Age 65 years or older
Detailed Elavil (amitriptyline) risks & warnings »
  • People under age 24
  • Glaucoma
  • Taking antidepressants
  • Taking opioids for pain relief or medicines for anxiety
  • Over age 65
Detailed Asendin (amoxapine) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
Elavilamoxapine
No food related info.
  • Take Asendin (amoxapine) with food to avoid stomach upset.
Pain
Elavilamoxapine
  • Low doses work well to treat certain kinds of chronic pain. It can take 2 weeks to feel the full effects of the medication.
No pain related info.
Sleep
Elavilamoxapine
  • Can cause dizziness, drowsiness, constipation, and weight gain.
  • You can feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
Weight
Elavilamoxapine
  • It's more likely to cause sleepiness, nausea, constipation, diarrhea, and weight gain (1 to 5 pounds) than other antidepressants.
No weight related info.
Upsides and benefits
Elavilamoxapine
  • Low doses work well to treat certain kinds of chronic pain. It can take 2 weeks to feel the full effects of the medication.
  • Low doses of Elavil (Amitriptyline) start working in 45 minutes to help you sleep better.
  • Six out of every ten people who use an antidepressant for the first time find that it works for them.
  • Asendin (amoxapine) can be used to treat more severe forms of depression.
  • Compared to similar medicines, Asendin (amoxapine) improves the mood in depression more quickly.
  • Asendin (amoxapine) is available as generic.
Downsides and risks
Elavilamoxapine
  • When used for depression, Elavil (Amitriptyline) causes more side effects and has a higher risk of overdose than other antidepressants. It's usually used when other medications haven't worked.
  • It's more likely to cause sleepiness, nausea, constipation, diarrhea, and weight gain (1 to 5 pounds) than other antidepressants.
  • People age 65 and older have a higher risk for this medication's side effects.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
  • Asendin (amoxapine) is not a first choice medicine for depression because of side effects.
  • In some people, Asendin (amoxapine) can stop working as early as 2-3 months after you start taking it.
  • Not recommended in older people, children under 16, or people who've had a history of seizures.
Tips from our pharmacists for people taking the medication
Elavilamoxapine
  • Take at bedtime to avoid some of its side effects.
  • Can cause dizziness, drowsiness, constipation, and weight gain.
  • Stop taking it slowly to avoid getting withdrawal symptoms.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • You can feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
  • You might not notice any changes in your mood for at least a few weeks.
  • Take Asendin (amoxapine) with food to avoid stomach upset.
  • You're more likely to be dehydrated and constipated. Drink plenty of fluids and be careful not to get overheated if you're out in the sun.
  • Don't stop taking Asendin (amoxapine) without talking to your doctor. Stopping Asendin (amoxapine) suddenly can be very dangerous.
Learn more
More about ElavilSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Elavil (amitriptyline)?
Worth itNot sureNot worth it
More about amoxapineSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Asendin (amoxapine)?
Worth itNot sureNot worth it