Compare Elavil vs. Horizant

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Elavil (Amitriptyline)

Prescription only
Improves mood and relieves certain kinds of pain.

Elavil (Amitriptyline) is an older antidepressant that's sometimes used to treat pain and sleep problems, but it can have more side effects than similar medications.

4.5/ 7 average rating with 134 reviewsforElavil
Calms leg movements and nerve pain.

Horizant (Gabapentin Enacarbil) is a good way to treat pain since it can be used with other pain medications and it's not addictive. You'll need to stop drinking alcohol and it can be somewhat expensive.

Upsides
  • Low doses work well to treat certain kinds of chronic pain. It can take 2 weeks to feel the full effects of the medication.
  • Low doses of Elavil (Amitriptyline) start working in 45 minutes to help you sleep better.
  • Six out of every ten people who use an antidepressant for the first time find that it works for them.
  • Not habit-forming or addictive.
  • Can be used with other pain medications.
  • Only has to be taken once or twice a day.
Downsides
  • When used for depression, Elavil (Amitriptyline) causes more side effects and has a higher risk of overdose than other antidepressants. It's usually used when other medications haven't worked.
  • It's more likely to cause sleepiness, nausea, constipation, diarrhea, and weight gain (1 to 5 pounds) than other antidepressants.
  • People age 65 and older have a higher risk for this medication's side effects.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
  • Need to avoid alcohol while on Horizant (Gabapentin Enacarbil).
  • Has to be taken with food.
  • If you want to stop taking this medication, you need to talk to your doctor first since stopping it cold turkey can cause seizures.
  • Not available as a generic.
Used for
Dosage forms
  • Pill
  • Pill
Price
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$4
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$378.3
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Reviews
134 
53%
think this treatment is worth it
36%
think this treatment works well
25%
think this treatment is a hassle

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Side effects
The Elavil (Amitriptyline) FDA package insert doesn’t have numbers about how common side effects are.
The Horizant (Gabapentin Enacarbil) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Suicidal thoughts or behavior

    Age 24 years or younger

  • Mania

    History of bipolar disorder

    ...and 1 more risk factors

  • Heart problems

    History of cardiovascular disease

  • Low blood pressure

    Age 65 years or older

  • Anticholinergic effects

    Age 65 years or older

See more detailed risks and warnings
  • Seizures

    Stopping Horizant (Gabapentin Enacarbil) suddenly

See more detailed risks and warnings