Compare Elavil vs. Viibryd

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Elavil (Amitriptyline)

Prescription only

Viibryd (Vilazodone)

Prescription only
Improves mood and relieves certain kinds of pain.

Elavil (Amitriptyline) is an older antidepressant that's sometimes used to treat pain and sleep problems, but it can have more side effects than similar medications.

3.3/ 5 average rating with 134 reviewsforElavil
Treats depression.

Viibryd (Vilazodone) is a good option to treat depression, but it often causes stomach and intestinal problems, including diarrhea.

4.0/ 5 average rating with 95 reviewsforViibryd
Upsides
  • Low doses work well to treat certain kinds of chronic pain. It can take 2 weeks to feel the full effects of the medication.
  • Low doses of Elavil (Amitriptyline) start working in 45 minutes to help you sleep better.
  • Six out of every ten people who use an antidepressant for the first time find that it works for them.
  • Viibryd (Vilazodone) improves depressive symptoms in people with major depressive disorder.
  • The dose of Viibryd (Vilazodone) doesn’t need to be changed if you have severe kidney disease.
  • Compared to other antidepressants, it has a lower risk of weight gain and causing problems with sexual function.
Downsides
  • When used for depression, Elavil (Amitriptyline) causes more side effects and has a higher risk of overdose than other antidepressants. It's usually used when other medications haven't worked.
  • It's more likely to cause sleepiness, nausea, constipation, diarrhea, and weight gain (1 to 5 pounds) than other antidepressants.
  • People age 65 and older have a higher risk for this medication's side effects.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
  • You shouldn’t take Viibryd (Vilazodone) if you have severe liver problems.
  • Can’t take Viibryd (Vilazodone) with drugs called monoamine oxidase inhibitors (MAOIs).
  • Need to avoid drinking alcohol while taking Viibryd (Vilazodone).
Used for
Dosage forms
  • Pill
  • Pill
Price
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Reviews
134 reviews so far
53%
saidit'sworth it
36%
saiditworked well
25%
saidit'sa big hassle

Have you used Elavil (Amitriptyline)?

Leave a review
95 reviews so far
67%
saidit'sworth it
63%
saiditworked well
13%
saidit'sa big hassle

Have you used Viibryd (Vilazodone)?

Leave a review
Side effects
The Elavil (Amitriptyline) FDA package insert doesn’t have numbers about how common side effects are.
26possible side effects
  • Diarrhea
    28%
  • Nausea
    23%
  • Dizziness
    9%
  • Dry mouth
    8%
  • Insomnia
    6%
  • Vomiting
    5%
  • Decreased libido
    5%
  • Abnormal dreams
    4%
  • Libido decreased
    4%
  • Fatigue
    4%
  • Abnormal orgasm
    4%
  • Dyspepsia
    3%
  • Flatulence
    3%
  • Gastroenteritis
    3%
  • Somnolence
    3%
  • Paresthesia
    3%
  • Restlessness
    3%
  • Orgasm abnormal
    3%
  • Arthralgia
    3%
  • Tremor
    2%
  • Feeling jittery
    2%
  • Palpitations
    2%
  • Delayed ejaculation
    2%
  • Erectile dysfunction
    2%
  • Increased appetite
    2%
  • Sexual dysfunction
    2%
See more detailed side effects
Risks and risk factors
  • Suicidal thoughts or behavior
    • Age 24 years or younger
  • Mania
    • History of bipolar disorder
    • At risk for bipolar disorder
  • Heart problems
    • History of cardiovascular disease
  • Low blood pressure
    • Age 65 years or older
  • Anticholinergic effects
    • Age 65 years or older
See more detailed risks and warnings
  • Suicidal thoughts or behavior
    • Age 18 years or younger
  • Monoamine oxidase inhibitor (MAOI) interaction
    • Taking Viibryd (Vilazodone) with MAOIs
    • Taking Viibryd (Vilazodone) with Zyvox or methylene blue
  • Serotonin syndrome
    • Taking Viibryd (Vilazodone) with other drugs that increase serotonin
  • Abnormal bleeding
    • Taking Viibryd (Vilazodone) with NSAIDs, warfarin, aspirin, or other drugs that affect clotting
  • Risk to fetus
    • Women of childbearing age
  • Eye problems
    • History of glaucoma
  • Activation of mania/hypomania
    • History of bipolar disorder (mixed/mania)
See more detailed risks and warnings