Compare Eldepryl vs. Azilect

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Eldepryl
(selegiline)

Azilect
(rasagiline)

Treats Parkinson's disease. Used with other medicines for Parkinson's disease to boost its effect.Treats Parkinson's disease. Azilect (rasagiline) is one of the recommended medicines to treat Parkinson's disease. It is now available in generic, which makes it more affordable for people without insurance.
Reviews & ratings
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Have you used Eldepryl (selegiline)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Azilect (rasagiline)?
Worth itNot sureNot worth it
Side effects
EldeprylAzilect
  • Skin irritation at the patch 12%
  • Headache 1%
  • Insomnia 5%
  • Diarrhea 2%
  • Dry mouth 2%
  • Weight loss of at least 5% 2%
  • Indigestion 1%
  • Rash 2%
  • Sinus infection 2%
  • Sore throat 1%
More Eldepryl side effects »
  • Difficulty controlling movement 8%
  • Headache 2%
  • Accidental injury 7%
  • Nausea 4%
  • Falls 3%
  • Low blood pressure 6%
  • Constipation 4%
  • Weight loss 6%
  • Joint pain 4%
  • Diarrhea 3%
More Azilect side effects »
How it works
EldeprylAzilect
Eldepryl (selegiline) is a selective monoamine oxidase inhibitor. It regulates the amount of dopamine in your body.Azilect (rasagiline) is a monoamine oxidase inhibitor. It increases the amount of dopamine in the brain, which helps those with Parkinson's disease gain better control their movements.
Type of medication
EldeprylAzilect
Prescription onlyPrescription only
Available as
EldeprylAzilect
  • Pill
  • Dissolving tablet
  • Pill
Used for
EldeprylAzilect
Risk factors for serious side effects
EldeprylAzilect
  • Eating foods rich in tyramine, like soy sauce, fermented cheese and smoked meats
  • Taking cough and cold medicines like dextromethorphan (Robitussin DM), pseudoephedrine (Sudafed)
  • Tricyclic antidepressants
  • Fentanyl
  • Tramadol
Detailed Eldepryl (selegiline) risks & warnings »
  • Eating foods rich in tyramine, like soy sauce, fermented cheese and smoked meats
  • Tricyclic antidepressants
  • Fentanyl
  • Tramadol
  • Buspirone
Detailed Azilect (rasagiline) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
EldeprylAzilect
  • Avoid eating foods high in tyramine while taking Eldepryl (selegiline), since it can increase your blood pressure.
No food related info.
Upsides and benefits
EldeprylAzilect
  • There are two different versions of Eldepryl (selegiline), a quick dissolving tablet and a regular tablet.
  • Eldepryl (selegiline) is one of the recommended medicines you can take along with carbidopa/levodopa if your Parkinson's disease is getting worse.
  • Azilect (rasagiline) is one of the go-to medicines for Parkinson's disease. It can be used in early and late stages of the disease.
  • Taking Azilect (rasagiline) by itself can help slow down Parkinson's disease, but it works better when it's given with other medicines.
  • Azilect (rasagiline) is available as generic as well as brand name, so there are usually lower out-of-pocket costs for you with insurance.
Downsides and risks
EldeprylAzilect
  • You may have to limit the amount of cheese, smoked meat, and soy sauce you eat while taking Eldepryl (selegiline) since it can raise your blood pressure.
  • Can keep you up at night if you take it later in the day
  • Doesn't work by itself to treat Parkinson's disease.
  • It can cause unusual cravings and changes in behavior in some people.
Tips from our pharmacists for people taking the medication
EldeprylAzilect
  • Watch how much smoked meat, cheese, pickles and soy sauce you eat while taking Eldepryl (selegiline) since it can raise your blood pressure.
  • Avoid taking your doses later in the day because it can keep you up.
  • Don't stop Eldepryl (selegiline) suddenly without talking to your doctor, since it can be dangerous.
  • Azilect (rasagiline) can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
  • Watch how much cheese, soy sauce or smoked meats you eat. Eating too much of these foods while on Azilect (rasagiline) can cause an unsafe rise in blood pressure.
  • Azilect (rasagiline) can make you dizzy or lightheaded, especially when you suddenly stand up from sitting or laying down.
  • Don't stop taking Azilect (rasagiline) without talking to your doctor first. Stopping it suddenly can cause confusion, stiff muscles and a high fever.
  • Azilect (rasagiline) can prevent many medicines from working properly. Check with your doctor or pharmacist if the way you take your other medicines needs to be changed.
Learn more
More about EldeprylSide effectsAlternativesFDA package insert
Have you used Eldepryl (selegiline)?
Worth itNot sureNot worth it
More about AzilectSide effectsAlternativesFDA package insert
Have you used Azilect (rasagiline)?
Worth itNot sureNot worth it