Compare Eldepryl vs. carbidopa / levodopa / entacapone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Eldepryl
(selegiline)

Stalevo
(carbidopa / levodopa / entacapone)

Treats Parkinson's disease. Used with other medicines for Parkinson's disease to boost its effect.Treats Parkinson's disease. Stalevo (carbidopa / levodopa / entacapone) is a good choice for Parkinson's disease, especially when carbidopa/levodopa starts losing its effect.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected

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Have you used Eldepryl (selegiline)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Stalevo (carbidopa / levodopa / entacapone)?
Worth itNot sureNot worth it
Side effects
Eldeprylcarbidopa / levodopa / entacapone
  • Skin irritation at the patch 12%
  • Headache 1%
  • Sleep difficulty 5%
  • Diarrhea 2%
  • Dry mouth 2%
  • Weight loss of at least 5% 2%
  • Indigestion 1%
  • Rash 2%
  • Sinus infection 2%
  • Sore throat 1%
More Eldepryl side effects »
  • Difficulty controlling movements 10%
  • Muscle spasm 5%
  • Changes in urine color 10%
  • Discolored urine 10%
  • Muscle rigidity 1%
  • Abdominal pain 4%
  • Dizziness 2%
  • Fatigue 2%
  • Constipation 2%
More carbidopa / levodopa / entacapone side effects »
How it works
Eldeprylcarbidopa / levodopa / entacapone
Eldepryl (selegiline) is a selective monoamine oxidase inhibitor. It regulates the amount of dopamine in your body.Stalevo (carbidopa / levodopa / entacapone) is a combination of carbidopa, levodopa, and entacapone. Entacopone and carbidopa prevent breakdown of levodopa in the body so that levodopa can then enter the brain and relieve symptoms of Parkinson's disease.
Type of medication
Eldeprylcarbidopa / levodopa / entacapone
Prescription onlyPrescription only
Available as
Eldeprylcarbidopa / levodopa / entacapone
  • Pill
  • Dissolving tablet
  • Pill
Used for
Eldeprylcarbidopa / levodopa / entacapone
Risk factors for serious side effects
Eldeprylcarbidopa / levodopa / entacapone
  • Eating foods rich in tyramine, like soy sauce, fermented cheese and smoked meats
  • Taking cough and cold medicines like dextromethorphan (Robitussin DM), pseudoephedrine (Sudafed)
  • Tricyclic antidepressants
  • Fentanyl
  • Tramadol
Detailed Eldepryl (selegiline) risks & warnings »
  • History of stomach ulcers
Detailed Stalevo (carbidopa / levodopa / entacapone) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
Eldeprylcarbidopa / levodopa / entacapone
  • Avoid eating foods high in tyramine while taking Eldepryl (selegiline), since it can increase your blood pressure.
No food related info.
Upsides and benefits
Eldeprylcarbidopa / levodopa / entacapone
  • There are two different versions of Eldepryl (selegiline), a quick dissolving tablet and a regular tablet.
  • Eldepryl (selegiline) is one of the recommended medicines you can take along with carbidopa/levodopa if your Parkinson's disease is getting worse.
  • It combines three medicines into one pill so you don't have to take so many pills daily.
  • Stalevo (carbidopa / levodopa / entacapone) is available as a generic.
Downsides and risks
Eldeprylcarbidopa / levodopa / entacapone
  • You may have to limit the amount of cheese, smoked meat, and soy sauce you eat while taking Eldepryl (selegiline) since it can raise your blood pressure.
  • Can keep you up at night if you take it later in the day
  • Doesn't work by itself to treat Parkinson's disease.
  • You would first start by taking Stalevo (carbidopa / levodopa / entacapone) as two different pills, carbidopa/levodopa and entacapone, before you get switched over to Stalevo (carbidopa / levodopa / entacapone).
  • It's less customizable since there are only a few fixed combinations available.
Tips from our pharmacists for people taking the medication
Eldeprylcarbidopa / levodopa / entacapone
  • Watch how much smoked meat, cheese, pickles and soy sauce you eat while taking Eldepryl (selegiline) since it can raise your blood pressure.
  • Avoid taking your doses later in the day because it can keep you up.
  • Don't stop Eldepryl (selegiline) suddenly without talking to your doctor, since it can be dangerous.
  • Stalevo (carbidopa / levodopa / entacapone) can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
  • Your saliva, sweat and urine may have dark color and stain your clothing while taking Stalevo (carbidopa / levodopa / entacapone).
  • Take Stalevo (carbidopa / levodopa / entacapone) 30-60 minutes before a meal so that your body can properly absorb it. Don't eat too much high protein foods (meat, milk, cheese or nuts) because doing so can prevent it from getting absorbed into your body.
  • Stalevo (carbidopa / levodopa / entacapone) may cause unusual cravings in some people.
Learn more
More about EldeprylSide effectsAlternativesFDA package insert
Have you used Eldepryl (selegiline)?
Worth itNot sureNot worth it
More about carbidopa / levodopa / entacaponeSide effectsAlternativesFDA package insert
Have you used Stalevo (carbidopa / levodopa / entacapone)?
Worth itNot sureNot worth it