Compare Eldepryl vs. Rytary

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Eldepryl (selegiline)

Prescription only
Treats Parkinson's disease.

Used with other medicines for Parkinson's disease to boost its effect.

Treats Parkinson's disease.

Rytary (carbidopa / levodopa) can be used to treat Parkinson's disease, but it can be expensive.

Upsides
  • There are two different versions of Eldepryl (selegiline), a quick dissolving tablet and a regular tablet.
  • Eldepryl (selegiline) is one of the recommended medicines you can take along with carbidopa/levodopa if your Parkinson's disease is getting worse.
  • Rytary (carbidopa / levodopa) comes in 4 different strengths.
  • If you have private prescription insurance, there are programs to make Rytary (carbidopa / levodopa) more affordable.
Downsides
  • You may have to limit the amount of cheese, smoked meat, and soy sauce you eat while taking Eldepryl (selegiline) since it can raise your blood pressure.
  • Can keep you up at night if you take it later in the day
  • Doesn't work by itself to treat Parkinson's disease.
  • There are other forms of Rytary (carbidopa / levodopa) that are generic and much cheaper.
  • Your doctor might have to change the dose of Rytary (carbidopa / levodopa) often before they find a dose that works for you.
  • Rytary (carbidopa / levodopa) can cause uncontrollable movements to happen, but this doesn't happen for 3 to 5 years.
  • Rytary (carbidopa / levodopa) is not a cure for Parkinson's disease; it can only slow the disease down.
Used for
Dosage forms
  • Pill
  • Dissolving tablet
  • Extended release capsule
Price
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Reviews
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Side effects
11possible side effects
  • Skin irritation at the patch
    24%
  • Headache
    18%
  • Insomnia
    12%
  • Diarrhea
    9%
  • Dry mouth
    8%
  • Weight loss of at least 5%
    5%
  • Indigestion
    4%
  • Rash
    4%
  • Sore throat
    3%
  • Sinus infection
    3%
  • Weight gain of at least 5%
    2%
See more detailed side effects
11possible side effects
  • Nausea
    20%
  • Headache
    17%
  • Dizziness
    12%
  • Dry mouth
    7%
  • Trouble sleeping
    6%
  • Abnormal dreams
    5%
  • Difficulty controlling movements
    5%
  • Anxiety
    5%
  • Vomiting
    5%
  • Changes in blood pressure
    5%
  • Constipation
    2%
See more detailed side effects
Risks and risk factors
  • Increased blood pressure
    • Eating foods rich in tyramine, like soy sauce, fermented cheese and smoked meats
    • Taking cough and cold medicines like dextromethorphan (Robitussin DM), pseudoephedrine (Sudafed)
  • Serotonin syndrome
    • Tricyclic antidepressants
    • Fentanyl
    • Tramadol
    • Buspirone
    • ADHD medicines
    • Triptans
  • Increased risk of skin cancer
  • Falling asleep during the day
    • Taking other medicines for Parkinson's
  • Low blood pressure
See more detailed risks and warnings
  • Falling asleep during the day
    • Taking other medicines for Parkinson's disease
  • High fever and confusion
    • Stopping Rytary (carbidopa / levodopa) suddenly
  • Changes in behavior
  • Lack of impulse control
    • Taking other medicines for Parkinson's disease
  • Heart attack
    • History of heart attack
    • High risk for heart attack
See more detailed risks and warnings