Compare Eldepryl vs. Rytary

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Eldepryl
(selegiline)

Rytary
(carbidopa / levodopa)

Treats Parkinson's disease. Used with other medicines for Parkinson's disease to boost its effect.Treats Parkinson's disease. Rytary (carbidopa / levodopa) can be used to treat Parkinson's disease, but it can be expensive.
Reviews & ratings
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Have you used Eldepryl (selegiline)?
Worth itNot sureNot worth it

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Have you used Rytary (carbidopa / levodopa)?
Worth itNot sureNot worth it
Side effects
EldeprylRytary
  • Skin irritation at the patch 12%
  • Headache 1%
  • Insomnia 5%
  • Diarrhea 2%
  • Dry mouth 2%
  • Weight loss of at least 5% 2%
  • Indigestion 1%
  • Rash 2%
  • Sinus infection 2%
  • Sore throat 1%
More Eldepryl side effects »
  • Nausea 5%
  • Dizziness 4%
  • Dry mouth 2%
  • Abnormal dreams 2%
  • Difficulty controlling movements 2%
  • Anxiety 2%
  • Constipation 1%
More Rytary side effects »
How it works
EldeprylRytary
Eldepryl (selegiline) is a selective monoamine oxidase inhibitor. It regulates the amount of dopamine in your body.Rytary (carbidopa / levodopa) is a combination of carbidopa and levodopa. Levodopa enters the brain and relieves the symptoms of Parkinson's disease. Carbidopa prevents levodopa from being broken down before it can enter the brain.
Type of medication
EldeprylRytary
Prescription onlyPrescription only
Available as
EldeprylRytary
  • Pill
  • Dissolving tablet
  • Extended release capsule
Used for
EldeprylRytary
Risk factors for serious side effects
EldeprylRytary
  • Eating foods rich in tyramine, like soy sauce, fermented cheese and smoked meats
  • Taking cough and cold medicines like dextromethorphan (Robitussin DM), pseudoephedrine (Sudafed)
  • Tricyclic antidepressants
  • Fentanyl
  • Tramadol
Detailed Eldepryl (selegiline) risks & warnings »
  • Taking other medicines for Parkinson's disease
  • Stopping Rytary (carbidopa / levodopa) suddenly
  • History of heart attack
  • High risk for heart attack
Detailed Rytary (carbidopa / levodopa) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
EldeprylRytary
  • Avoid eating foods high in tyramine while taking Eldepryl (selegiline), since it can increase your blood pressure.
No food related info.
Sleep
EldeprylRytary
No sleep related info.
  • Rytary (carbidopa / levodopa) can make you sleepy or fall asleep suddenly without warning. Don't drive or do anything that requires concentration until you know how Rytary (carbidopa / levodopa) affects you. You're more at risk if you're taking other medicines for Parkinson's disease. Talk to your doctor if this bothers you.
Upsides and benefits
EldeprylRytary
  • There are two different versions of Eldepryl (selegiline), a quick dissolving tablet and a regular tablet.
  • Eldepryl (selegiline) is one of the recommended medicines you can take along with carbidopa/levodopa if your Parkinson's disease is getting worse.
  • Rytary (carbidopa / levodopa) comes in 4 different strengths.
  • If you have private prescription insurance, there are programs to make Rytary (carbidopa / levodopa) more affordable.
Downsides and risks
EldeprylRytary
  • You may have to limit the amount of cheese, smoked meat, and soy sauce you eat while taking Eldepryl (selegiline) since it can raise your blood pressure.
  • Can keep you up at night if you take it later in the day
  • Doesn't work by itself to treat Parkinson's disease.
  • There are other forms of Rytary (carbidopa / levodopa) that are generic and much cheaper.
  • Your doctor might have to change the dose of Rytary (carbidopa / levodopa) often before they find a dose that works for you.
  • Rytary (carbidopa / levodopa) can cause uncontrollable movements to happen, but this doesn't happen for 3 to 5 years.
  • Rytary (carbidopa / levodopa) is not a cure for Parkinson's disease; it can only slow the disease down.
Tips from our pharmacists for people taking the medication
EldeprylRytary
  • Watch how much smoked meat, cheese, pickles and soy sauce you eat while taking Eldepryl (selegiline) since it can raise your blood pressure.
  • Avoid taking your doses later in the day because it can keep you up.
  • Don't stop Eldepryl (selegiline) suddenly without talking to your doctor, since it can be dangerous.
  • If you can't swallow the capsules whole, they can be sprinkled on 1 to 2 tablespoons of applesauce. You have to take it right away.
  • Don't drive or do anything requiring concentration until you know how Rytary (carbidopa / levodopa) affects you.
  • You can't switch off other forms of carbidopa/levodopa to Rytary (carbidopa / levodopa) without talking to your doctor or pharmacist. They'll tell you how to do it safely.
Learn more
More about EldeprylSide effectsAlternativesFDA package insert
Have you used Eldepryl (selegiline)?
Worth itNot sureNot worth it
More about RytarySide effectsAlternativesFDA package insert
Have you used Rytary (carbidopa / levodopa)?
Worth itNot sureNot worth it