Compare Eliquis vs. Pradaxa

Head-to-head comparisons of medication uses, side effects, ratings, and more.



Prevents blood clots. Eliquis (Apixaban) is an easy to use and effective way to prevent blood clots from forming in your veins.Prevents blood clots. Pradaxa (Dabigatran) is a good medication for preventing blood clots. It doesn't require regular blood tests or changing doses often. It can be expensive and there's no way to reverse the medication's effects.
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Reviews & ratings
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Side effects
  • All bleeding 6%
  • Nosebleed 3%
  • Nonmajor bleeding 2%
  • Collection of blood 1%
More Eliquis side effects »

The Pradaxa FDA package insert doesn’t have numbers about how common side effects are.

More about Pradaxa side effects »
How it works
Eliquis (Apixaban) is a factor Xa inhibitor anticoagulant and prevents the formation of blood clots in your veins.Pradaxa (Dabigatran) is an anticoagulant that stops the formation of blood clots.
Type of medication
Factor Xa inhibitor
Prescription only
Thrombin inhibitor
Prescription only
Available as
  • Pill
  • Pill
Used for (click to learn more)
Risk factors for serious side effects
  • Stopping Eliquis (Apixaban) early
  • Spinal puncture (spinal tap)
  • Getting anesthesia in the spine (epidural anesthesia)
  • History of bleeding problems
  • Severe high blood pressure
  • Older age
  • Artificial heart valve
  • Current kidney problems
  • Current liver problems
Detailed Eliquis (Apixaban) risks & warnings »
  • Stopping Pradaxa (Dabigatran) too soon
  • Spinal tap
  • Anesthesia along the spine (epidural anesthesia)
  • Taking NSAIDs, aspirin, or other blood-thinning medicines
  • Drug interactions
  • Taking with NSAIDs, aspirin, or other blood-thinning medicines
    • Artificial heart valve
    Detailed Pradaxa (Dabigatran) risks & warnings »
    Pregnancy category
    BFDA pregnancy category (Probably safe)

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    See the FDA package insert
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    No specific alcohol-related info.No specific alcohol-related info.
    • Take twice a day, with or without food, at the same time each day.
    No specific food-related info.
    Kidneys and liver
    • Eliquis (Apixaban) is processed by the kidney and liver. If you have kidney or liver problems, talk to your doctor about possibly switching to a different medicine to prevent increased risk for side effects.
    No specific kidneys and liver-related info.
    No specific sex-related info.No specific sex-related info.
    No specific sleep-related info.No specific sleep-related info.
    No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    • Eliquis (Apixaban) is very effective in reducing the threat of stroke in people with Afib or other clotting disorders.
    • Eliquis (Apixaban) doesn't require regular blood testing and doesn't have dietary restrictions.
    • If you've had clots in your legs or lungs before, Eliquis (Apixaban) can lower the risk of these forming again.
    • Clinical studies have shown that the risk of stroke and blood clots is lower than with warfarin, another popular "blood thinner" (anticoagulant).
    • Doesn't require regular blood tests or frequent dose changes.
    • In studies comparing Pradaxa (Dabigatran) to other "blood thinners", it worked just as well in preventing strokes and was better in lowering the risk of bleeding.
    Downsides and risks
    • You can bruise easier and if you cut yourself, it'll take longer to stop the bleeding. Always look for signs of internal bleeding, such as dark urine or blood in your stool.
    • Can't be used if you have artificial heart valves.
    • Never stop taking Eliquis (Apixaban) without talking to your doctor first.
    • Eliquis (Apixaban) isn't available as a generic, so it can be pricey.
    • Not available as generic.
    • There are no antidotes to stop bleeding caused by taking too much Pradaxa (Dabigatran).
    • Can't take during pregnancy.
    Tips from our pharmacists for people taking the medication
    • Take twice a day, with or without food, at the same time each day.
    • Needs to be stopped prior to dental procedures or surgery.
    • You can bruise easier and if you have a cut, it can take longer for bleeding to stop.
    • Do not take with other drugs that affect your blood, like aspirin, ibuprofen, warfarin, or SSRIs.
    • Call a doctor immediately if you have dizziness, weakness, or a really bad headache.
    • Pradaxa (Dabigatran) is an anticoagulant, so it's important not to miss a dose. Don't stop taking this medication without talking to your doctor first.
    • When taking Pradaxa (Dabigatran), you can bleed more easily, so use a soft toothbrush and an electric razor to avoid cutting yourself.
    • Take this exactly as your doctor or pharmacist tells you to.
    • Take with a full glass of water. Swallow the capsule whole. Don't chew, break, or open the capsule.
    Learn more
    More about EliquisSide effectsReviews & ratingsAlternativesFDA package insert
    More about PradaxaSide effectsReviews & ratingsAlternativesFDA package insert