Compare Eliquis vs. Xarelto

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Eliquis (apixaban)

Prescription only

Xarelto (rivaroxaban)

Prescription only
Prevents blood clots.

Eliquis (apixaban) is an effective way to prevent blood clots from forming in your veins, but you have to take it twice a day, and your doctor might have to change the dose a lot.

5.3/ 7 average rating with 19 reviewsforEliquis
Prevents blood clots.

Xarelto (rivaroxaban) is a good medication for preventing blood clots. It doesn't require regular blood tests or changing doses often. However, it can be expensive and there's no way to reverse the medication's effects.

4.8/ 7 average rating with 22 reviewsforXarelto
Upsides
  • Eliquis (apixaban) is very effective in reducing the risk of stroke in people with atrial fibrilation or other clotting disorders.
  • You don't need to have regular blood tests on Eliquis (apixaban), and you don't have to regulate your diet like other blood thinners.
  • If you've had clots in your legs or lungs before, Eliquis (apixaban) can lower the risk of these forming again.
  • Studies show that Xarelto (rivaroxaban) works just as well as other blood thinners (anticoagulants) in preventing strokes and stopping clots from froming.
  • Xarelto (rivaroxaban) doesn't require regular blood tests or frequent dose changes.
  • Xarelto (rivaroxaban) doesn't interact with as many types of food as other blood thinners like warfarin (Coumadin).
Downsides
  • You can bruise easier and if you cut yourself, it'll take longer to stop the bleeding. Always look for signs of internal bleeding, such as dark urine or bloody stools.
  • Can't be used if you have artificial heart valves.
  • Never stop taking Eliquis (apixaban) without talking to your doctor first.
  • Eliquis (apixaban) isn't available as a generic, so it can be expensive.
  • If you've taken too much Eliquis (apixaban) and you're bleeding, it can be harder to treat compared to other blood thinners.
  • Xarelto (rivaroxaban) can increase your risk of bleeding, so call your doctor right away if you see blood in your spit, urine, or stool (look for black, tarry stools or bright red blood).
  • Xarelto (rivaroxaban) isn't available as a generic medication.
  • There are no antidotes to stop bleeding caused by taking too much Xarelto (rivaroxaban).
  • You can't take Xarelto (rivaroxaban) if you are pregnant.
Used for
Dosage forms
  • Pill
  • Pill
Price
Lowest price near you
$405.63
Find instant savings
Lowest price near you
$405.29
Find instant savings
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at Kroger, Albertsons, Safeway, and other pharmacies.
Reviews
19 
47%
think this treatment is worth it
58%
think this treatment works well
21%
think this treatment is a hassle

Have you used Eliquis (apixaban)?

Leave a review
22 
45%
think this treatment is worth it
45%
think this treatment works well
9%
think this treatment is a hassle

Have you used Xarelto (rivaroxaban)?

Leave a review
Side effects
1possible side effects
  • Major bleed
    2%
See more detailed side effects
2possible side effects
  • Major bleeding needing transfusion
    4%
  • Bleeding in the stomach & intestines
    2%
See more detailed side effects
Risks and warnings
  • Increased risk of stroke or blood clots from early discontinuation

    Stopping Eliquis (apixaban) prematurely

  • Paralysis in the spine

    Spinal puncture (spinal tap)

    ...and 3 more risk factors

  • Increased risk of stroke or bleeding

    Artificial heart valve

  • Increased side effects in kidney or liver conditions

    Current kidney problems

    ...and 1 more risk factors

See more detailed risks and warnings
  • Blood clots and stroke

    Stopping Xarelto (rivaroxaban) too soon

    ...and 1 more risk factors

  • Blood clot in the spine

    Spinal puncture (spinal tap)

    ...and 1 more risk factors

  • Unusual bleeding

    History of bleeding problems

    ...and 4 more risk factors

  • Increased side effects

    Current kidney problems

    ...and 1 more risk factors

See more detailed risks and warnings