Compare Eliquis vs. Xarelto

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Eliquis
(apixaban)

Xarelto
(rivaroxaban)

Prevents blood clots. Eliquis (apixaban) is an effective way to prevent blood clots from forming in your veins, but you have to take it twice a day, and your doctor might have to change the dose a lot.Prevents blood clots. Xarelto (rivaroxaban) is a good medication for preventing blood clots. It doesn't require regular blood tests or changing doses often. However, it can be expensive and there's no way to reverse the medication's effects.
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Coupons for Eliquis
Best available price for 60 (5mg) tablets of eliquis
Coupons for Xarelto
Best available price for 30 (20mg) tablets of xarelto
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.26Eliquis
Reviews for Eliquis
47%
of people (All ages) say Eliquis is worth it
58%
say it works well
21%
say it's a big hassle
Have you used Eliquis (apixaban)?
Worth itNot sureNot worth it
Reviews for Xarelto
45%
+2% better vs. Eliquis
45%
+13% better vs. Eliquis
9%
-12% worse vs. Eliquis
Have you used Xarelto (rivaroxaban)?
Worth itNot sureNot worth it
Side effects
EliquisXarelto
  • Major bleed 2%
  • Bleeding 12%
  • Nausea 3%
  • Low red blood cells 3%
  • All bleeding 15%
  • Nose bleeding 3%
  • Severe bruising 2%
  • Blood in the urine 2%
  • Nosebleeds 3%
  • Blood clots 1%
More Eliquis side effects »
  • Major bleeding needing transfusion 4%
  • Bleeding in the stomach & intestines 2%
  • Complaints of bleeding 28%
  • Clinically relevant but not major bleeding 9%
  • Back pain 3%
  • Upper abdominal pain 2%
  • Joint arthritis 1%
  • Any bleeding event after hip or knee replacement surgery 6%
  • Any side effect causing stopping of xarelto (rivaroxaban) 4%
  • Wound drainage 3%
More Xarelto side effects »
How it works
EliquisXarelto
Eliquis (apixaban) is a factor Xa inhibitor anticoagulant that stops the formation of blood clots in your body so you're less likely to have a stroke or heart attack.Xarelto (rivaroxaban) is an anticoagulant that stops blood clots from forming.
Type of medication
EliquisXarelto
Prescription onlyPrescription only
Available as
EliquisXarelto
  • Pill
  • Pill
Used for
EliquisXarelto
Risk factors for serious side effects
EliquisXarelto
  • Stopping Eliquis (apixaban) prematurely
  • Spinal puncture (spinal tap)
  • Getting anesthesia in the spine (epidural anesthesia)
  • History of spinal surgery
  • Concomitant use of nonsteroidal anti-inflammatory drugs (NSAIDs), or other blood-thinners
Detailed Eliquis (apixaban) risks & warnings »
  • Stopping Xarelto (rivaroxaban) too soon
  • Artificial heart valve
  • Spinal puncture (spinal tap)
  • Getting anesthesia in the spine (epidural anesthesia)
  • History of bleeding problems
Detailed Xarelto (rivaroxaban) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
EliquisXarelto
  • Eliquis (apixaban) can interact with different medicines. Make sure your doctor and pharmacist know all the medicines you're taking.
  • Xarelto (rivaroxaban) doesn't interact with as many types of food as other blood thinners like warfarin (Coumadin).
Food
EliquisXarelto
  • Take twice a day, with or without food, at the same time each day.
  • Like all blood thinners, it will take a little longer for your blood to clot if you start bleeding while you're taking Xarelto (rivaroxaban). Call your doctor if you notice bleeding that won't stop, a bruise that won't go away or gets worse, pink or brown urine, bright red or dark tarry stool, nose bleeds, or if you start coughing up blood.
Kidneys and liver
EliquisXarelto
  • Eliquis (apixaban) is broken down by the kidney and liver. If you already have problems with your kidney or liver, talk to your doctor to make sure Eliquis (apixaban) is right for you.
  • Xarelto (rivaroxaban) is processed by the kidney and liver. If you have kidney or liver problems, talk to your doctor about possibly switching to a different medicine to avoid other side effects.
Upsides and benefits
EliquisXarelto
  • Eliquis (apixaban) is very effective in reducing the risk of stroke in people with atrial fibrilation or other clotting disorders.
  • You don't need to have regular blood tests on Eliquis (apixaban), and you don't have to regulate your diet like other blood thinners.
  • If you've had clots in your legs or lungs before, Eliquis (apixaban) can lower the risk of these forming again.
  • Studies show that Xarelto (rivaroxaban) works just as well as other blood thinners (anticoagulants) in preventing strokes and stopping clots from froming.
  • Xarelto (rivaroxaban) doesn't require regular blood tests or frequent dose changes.
  • Xarelto (rivaroxaban) doesn't interact with as many types of food as other blood thinners like warfarin (Coumadin).
Downsides and risks
EliquisXarelto
  • You can bruise easier and if you cut yourself, it'll take longer to stop the bleeding. Always look for signs of internal bleeding, such as dark urine or bloody stools.
  • Can't be used if you have artificial heart valves.
  • Never stop taking Eliquis (apixaban) without talking to your doctor first.
  • Eliquis (apixaban) isn't available as a generic, so it can be expensive.
  • If you've taken too much Eliquis (apixaban) and you're bleeding, it can be harder to treat compared to other blood thinners.
  • Xarelto (rivaroxaban) can increase your risk of bleeding, so call your doctor right away if you see blood in your spit, urine, or stool (look for black, tarry stools or bright red blood).
  • Xarelto (rivaroxaban) isn't available as a generic medication.
  • There are no antidotes to stop bleeding caused by taking too much Xarelto (rivaroxaban).
  • You can't take Xarelto (rivaroxaban) if you are pregnant.
Tips from our pharmacists for people taking the medication
EliquisXarelto
  • Take twice a day, with or without food, at the same time each day.
  • If you're going to have a dental procedure or surgery, make sure your dentist or surgeon talks to your doctor first.
  • You can bruise easier while taking Eliquis (apixaban) and if you have a cut, it can take longer for bleeding to stop.
  • Eliquis (apixaban) can interact with different medicines. Make sure your doctor and pharmacist know all the medicines you're taking.
  • Call a doctor immediately if you have dizziness, weakness, or a really bad headache.
  • Xarelto (rivaroxaban) prevents blood from clotting, so it's important not to miss a dose. If you miss your daily dose, take it as soon as you remember that day. Just don't take two doses close to each other.
  • If you completely forget to take a dose, call your doctor right away.
  • When taking Xarelto (rivaroxaban), you can bleed more easily, so use a soft toothbrush and an electric razor to avoid cutting yourself.
  • You can crush the pills and mix it with a spoonful of applesauce, but make sure to eat some food and drink a glass of water right away.
Learn more
More about EliquisSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Eliquis (apixaban)?
Worth itNot sureNot worth it
More about XareltoSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Xarelto (rivaroxaban)?
Worth itNot sureNot worth it