Compare Enablex vs. Oxybutynin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Enablex
(darifenacin)

Oxytrol
(oxybutynin)

Treats overactive bladder. Enablex (darifenacin) is a good treatment for overactive bladder if exercises and other methods haven't worked.Treats an overactive bladder. Oxytrol (Oxybutynin) is a good treatment for overactive bladder, but watch out for side effects such as dry mouth and constipation.
Reviews & ratings
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Have you used Enablex (darifenacin)?
Worth itNot sureNot worth it

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Have you used Oxytrol (oxybutynin)?
Worth itNot sureNot worth it
Side effects
EnablexOxybutynin
  • Dry mouth 12%
  • Constipation 9%
  • Urinary tract infection 2%
  • Nausea 1%
  • Stomach pain 1%
  • Weakness 1%
  • Dry eyes 1%
  • Indigestion 5%
  • Dizziness 1%
  • Headache 1%
More Enablex side effects »

We haven’t found good data for Oxybutynin side effects.

FDA side effect reports for Oxybutynin »
How it works
EnablexOxybutynin
Enablex (darifenacin) is an antimuscarinic. It helps people control the urge to urinate by relaxing the bladder muscles and stopping them from spasming.Oxytrol (Oxybutynin) is an anticholinergic. It relaxes the bladder muscles by lowering muscle spasms. This helps people go to the bathroom less often and better control their urination.
Type of medication
EnablexOxybutynin
Prescription onlyPrescription only
Available as
EnablexOxybutynin
  • Pill
  • Pill
  • Extended release
  • Liquid
  • Cream, gel, or ointment
  • Patch
Used for
EnablexOxybutynin
Risk factors for serious side effects
EnablexOxybutynin
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • People age 65 or older
  • Glaucoma
  • History of bladder problems
Detailed Enablex (darifenacin) risks & warnings »
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Outside in hot weather
  • Dehydrated
  • Exercising
Detailed Oxytrol (oxybutynin) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Alcohol
EnablexOxybutynin
  • Drinks with caffeine, alcohol or carbonation can make your symptoms worse.
  • To prevent dry mouth, avoid using mouthwashes with alcohol, chew on sugar-free gum, and take small sips of water as needed.
Food
EnablexOxybutynin
No food related info.
  • Can be taken with or without food.
Kidneys and liver
EnablexOxybutynin
  • If you have liver problems, talk to your doctor before starting Enablex (darifenacin). You might have to use a lower dose, or you might not be able to take Enablex (darifenacin) at all.
No kidneys and liver related info.
Sleep
EnablexOxybutynin
  • You can get drowsy or dizzy on Enablex (darifenacin). Do not stand or sit up too quickly if you’ve been sitting or lying down for a while.
  • Enablex (darifenacin) can cause drowsiness and dizziness and can increase your risk for falls.
  • Oxytrol (Oxybutynin) can cause drowsiness, confusion, dizziness, hallucinations, or blurred vision. Avoid driving, operating machinery, or doing anything that requires you to be alert until you know how Oxytrol (Oxybutynin) affects you.
  • Might cause dry mouth, constipation, drowsiness, dizziness, and blurry vision.
  • Can cause drowsiness, so avoid taking with alcohol or other medicines that make you sleepy.
  • Generally not recommended to use in people ages 65 and older since it can cause drowsiness and increase the risk of falls.
Upsides and benefits
EnablexOxybutynin
  • Enablex (darifenacin) is effective at treating overactive bladder by lowering the urge to urinate, and helping to better control urination.
  • The tablet is available as a generic.
  • Enablex (darifenacin) is only taken once a day.
  • Oxytrol (Oxybutynin) is effective at treating overactive bladder by lowering the urge to urinate, and helping to better control urination.
  • Available in multiple forms: a patch, gel, extended-release tablet, and tablet.
  • The gel form of Oxytrol (Oxybutynin) is available over the counter without a prescription.
  • Oxytrol (Oxybutynin) patch and gel have fewer side effects than taking the tablet.
  • The tablet is available as a generic.
Downsides and risks
EnablexOxybutynin
  • Enablex (darifenacin) is only recommended after doing exercises, bladder training and changes to your lifestyle haven't helped.
  • Enablex (darifenacin) can cause drowsiness and dizziness and can increase your risk for falls.
  • Enablex (darifenacin) can cause severe dry mouth and eyes and constipation.
  • Generally not recommended if you are 65 or older.
  • Do not use if you have uncontrolled narrow-angle glaucoma.
  • Generally not recommended to use in people ages 65 and older since it can cause drowsiness and increase the risk of falls.
  • Can’t be used if you have uncontrolled narrow-angle glaucoma.
  • Not recommended if you have ulcerative colitis or certain other stomach problems since Oxytrol (Oxybutynin) can slow stomach emptying.
  • Not the best choice if you have GERD (acid reflux), since Oxytrol (Oxybutynin) can irritate your throat and make the acid reflux worse.
  • Has more side effects than newer medicines that treat overactive bladder.
Tips from our pharmacists for people taking the medication
EnablexOxybutynin
  • Enablex (darifenacin) can take up to 4 weeks before you notice any changes.
  • Drinks with caffeine, alcohol or carbonation can make your symptoms worse.
  • You can get drowsy or dizzy on Enablex (darifenacin). Do not stand or sit up too quickly if you’ve been sitting or lying down for a while.
  • You can take Enablex (darifenacin) with or without food.
  • Do not break, crush or chew the pills.
  • You can get overheated when it's too hot while on Enablex (darifenacin). Stay indoors, and don't exercise too hard when it’s hot outside.
  • Might cause dry mouth, constipation, drowsiness, dizziness, and blurry vision.
  • To prevent dry mouth, avoid using mouthwashes with alcohol, chew on sugar-free gum, and take small sips of water as needed.
  • Can be taken with or without food.
  • Let your doctor know if your symptoms don’t get better in two weeks. There could be other causes of your bladder problems or you may need to try a different medicine.
  • Can cause drowsiness, so avoid taking with alcohol or other medicines that make you sleepy.
Learn more
More about EnablexSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Enablex (darifenacin)?
Worth itNot sureNot worth it
More about OxybutyninSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Oxytrol (oxybutynin)?
Worth itNot sureNot worth it