Compare Enalapril vs. Lisinopril

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Vasotec
(Enalapril)

Zestril
(Lisinopril)

Lowers blood pressure. Enalapril is a good blood pressure-lowering medicine that protects kidney function.Lowers blood pressure. Zestril (Lisinopril) is a good blood pressure-lowering medicine that protects kidney function.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.2631578947368425Enalapril
Reviews for Vasotec (Enalapril)
44%
of people (All ages) say Vasotec (Enalapril) is worth it
40%
say it works well
21%
say it's a big hassle
Have you used Vasotec (Enalapril)?
Worth itNot sureNot worth it
Reviews for Zestril (Lisinopril)
61%
+17% vs. Vasotec (Enalapril)
51%
+11% vs. Vasotec (Enalapril)
13%
+8% vs. Vasotec (Enalapril)
676 reviews
Have you used Zestril (Lisinopril)?
Worth itNot sureNot worth it
Side effects
EnalaprilLisinopril
  • Diarrhea 1%
  • Vertigo 1%
More Enalapril side effects »
  • Dizziness 7%
  • Headache 4%
  • Cough 3%
  • Diarrhea 2%
  • Chest pain 2%
  • Fatigue 2%
  • Upper respiratory infection 1%
More Lisinopril side effects »
How it works
EnalaprilLisinopril
Enalapril is an angiotensin converting enzyme (ACE) inhibitor. It blocks a chemical that tightens blood vessels. This makes blood vessels relax, which lowers blood pressure and allows more blood and oxygen to get to your heart and other organs.Zestril (Lisinopril) is an angiotensin converting enzyme (ACE) inhibitor. It blocks a chemical that tightens blood vessels. This makes blood vessels relax, which lowers blood pressure and allows more blood and oxygen to get to your heart and other organs.
Type of medication
EnalaprilLisinopril
Antihypertensive
ACE inhibitor
Prescription only
Antihypertensive
ACE inhibitor
Prescription only
Available as
EnalaprilLisinopril
  • Pill
  • Liquid
  • Pill
Used for (click to learn more)
EnalaprilLisinopril
Risk factors for serious side effects
EnalaprilLisinopril
  • Women of childbearing age
    • African descent
    • Current kidney problems
    • Medicine that increase potassium
    • Use of salt substitute
    Detailed Vasotec (Enalapril) risks & warnings »
    • Women of childbearing age
      • African descent
      • Current kidney problems
      • Medicine that increase potassium
      • Use of salt substitute
      Detailed Zestril (Lisinopril) risks & warnings »
      Pregnancy

      Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Kidneys and liver
      EnalaprilLisinopril
      • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
      • Requires routine blood tests to check kidney function.
      • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
      • Requires routine blood tests to check kidney function.
      Upsides and benefits
      EnalaprilLisinopril
      • The only ACE inhibitor that doctors can give through an IV if that's needed.
      • A first-choice blood pressure treatment for many people.
      • Lowers the risk of heart attack and stroke.
      • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
      • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
      • A first-choice blood pressure treatment for many people.
      • Lowers the risk of heart attack and stroke.
      • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
      • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
      Downsides and risks
      EnalaprilLisinopril
      • Compared to other ACE inhibitors, less flexible on when you take it. Enalapril needs to be taken multiple times a day on an empty stomach.
      • Up to 1 in 10 people can get a dry cough with this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
      • Requires a yearly blood test to see how the medicine is affecting your body.
      • Not safe to use if you're pregnant.
      • Up to 1 in 10 people can get a dry cough with this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
      • Requires a yearly blood test to see how the medicine is affecting your body.
      • Not safe to use if you're pregnant.
      Tips from our pharmacists for people taking the medication
      EnalaprilLisinopril
      • Can cause dizziness in the first few days.
      • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
      • Tell your doctor about any dizziness, fatigue, cough, or throat irritation that doesn't go away.
      • Requires routine blood tests to check kidney function.
      • Don't take it if you're pregnant.
      • Can cause dizziness in the first few days.
      • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
      • Tell your doctor about any dizziness, fatigue, cough, or throat irritation that doesn't go away.
      • Requires routine blood tests to check kidney function.
      • Don't take it if you're pregnant.
      Learn more
      More about EnalaprilSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Vasotec (Enalapril)?
      Worth itNot sureNot worth it
      More about LisinoprilSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Zestril (Lisinopril)?
      Worth itNot sureNot worth it