Compare Enalapril vs. Toprol XL

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Vasotec
(enalapril)

Toprol XL
(metoprolol succinate)

Lowers blood pressure. Enalapril is a good blood pressure-lowering medicine that protects kidney function.Lowers blood pressure and controls heart rate. Toprol XL (metoprolol succinate) is good for controlling chest pain, treating heart failure, and heart attack. It has the added benefit of being taken once a day.
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Reviews & ratings
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4.26Enalapril
Reviews for Vasotec (enalapril)
44%
of people (All ages) say Vasotec (enalapril) is worth it
40%
say it works well
21%
say it's a big hassle
Have you used Vasotec (enalapril)?
Worth itNot sureNot worth it
Reviews for Toprol XL (metoprolol succinate)
60%
+16% better vs. Vasotec (enalapril)
54%
+14% better vs. Vasotec (enalapril)
13%
+8% better vs. Vasotec (enalapril)
164 reviews
Have you used Toprol XL (metoprolol succinate)?
Worth itNot sureNot worth it
Side effects
EnalaprilToprol XL
  • Low blood pressure 7%
  • Positional low blood pressure 2%
  • Muscle weakness 2%
  • Orthostatic effects 2%
  • Fainting 2%
More Enalapril side effects »
  • Tiredness 10%
  • Dizziness 10%
  • Low mood disorder 5%
  • Skin rash and itching 5%
  • Diarrhea 5%
  • Shortness of breath 3%
  • Slower heartbeat 3%
  • Dizziness/balance problems 1%
More Toprol XL side effects »
How it works
EnalaprilToprol XL
Enalapril is an angiotensin converting enzyme (ACE) inhibitor. It blocks a chemical that tightens blood vessels. This makes blood vessels relax, which lowers blood pressure and allows more blood and oxygen to get to your heart and other organs.Toprol XL (metoprolol succinate) is a beta blocker. It lowers blood pressure by slowing heart rate, relaxing blood vessels, and lowering the body's fight-or-flight response.
Type of medication
EnalaprilToprol XL
Prescription only
Prescription only
Available as
EnalaprilToprol XL
  • Pill
  • Liquid
  • Extended release
Used for
EnalaprilToprol XL
Risk factors for serious side effects
EnalaprilToprol XL
  • Women of childbearing age
    • African descent
    • Current kidney problems
    • Medicine that increase potassium
    • Use of salt substitute
    Detailed Vasotec (enalapril) risks & warnings »
    • Sudden discontinuation of medicine
    • Coronary artery disease
    • Diabetes
    • Hyperthyroidsim
    • Heart failure
    • Major surgery requiring anesthesia
    • History of asthma
    • History of COPD
    Detailed Toprol XL (metoprolol succinate) risks & warnings »
    Pregnancy

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Kidneys and liver
    EnalaprilToprol XL
    • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
    • Requires routine blood tests to check kidney function.
    No kidneys and liver related info.
    Upsides and benefits
    EnalaprilToprol XL
    • A first-choice blood pressure treatment for many people.
    • Lowers the risk of heart attack and stroke.
    • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
    • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
    • The only ACE inhibitor that doctors can give through an IV if that's needed.
    • A first-choice treatment to prevent chest pain (angina). It makes attacks less frequent and helps you be more active without having chest pain.
    • Toprol XL (metoprolol succinate) is a first-choice treatment for heart failure since it may prevent long-term heart damage.
    • It's also a first-choice for heart attack treatment since it lowers the risk of death during and after a heart attack.
    • Toprol XL (metoprolol succinate) is the extended release version of metoprolol tartrate and only needs to be taken once a day.
    • It's available as a generic and is relatively cheap.
    Downsides and risks
    EnalaprilToprol XL
    • Up to 1 in 10 people can get a dry cough with this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
    • Compared to other ACE inhibitors, less flexible on when you take it. Enalapril needs to be taken multiple times a day on an empty stomach.
    • Requires a yearly blood test to see how the medicine is affecting your body.
    • Not safe to use if you're pregnant.
    • Taking a beta blocker can make you feel more tired or out of breath during exercise or normal daily routines. This gets better for most people, but for some this may not go away.
    • It's not a first-choice treatment for high blood pressure according to the latest guidelines, except if you have heart failure or heart disease.
    • Toprol XL (metoprolol succinate) can hide symptoms of low blood sugar if you have diabetes.
    • You can't miss doses. Stopping Toprol XL (metoprolol succinate) suddenly can cause your blood pressure to go up quickly, which increases your risk of heart attack and stroke.
    Tips from our pharmacists for people taking the medication
    EnalaprilToprol XL
    • Can cause dizziness in the first few days.
    • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
    • Tell your doctor about any dizziness, fatigue, cough, or throat irritation that doesn't go away.
    • Requires routine blood tests to check kidney function.
    • Don't take it if you're pregnant.
    • Toprol XL (metoprolol succinate) cause dizziness in the first few days.
    • Check your blood pressure 1 week after starting this medicine and let your doctor know if it hasn't improved.
    • It can make you feel tired or give you headaches.
    • Can hide symptoms of low blood sugar, so be careful taking this if you have diabetes.
    • Don't stop taking this medicine suddenly.
    • This is the extended-release version, but it also comes in an immediate-release form, metoprolol tartrate.
    Learn more
    More about EnalaprilSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Vasotec (enalapril)?
    Worth itNot sureNot worth it
    More about Toprol XLSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Toprol XL (metoprolol succinate)?
    Worth itNot sureNot worth it