Compare Enbrel vs. Arava

Head-to-head comparisons of medication uses, side effects, ratings, and more.



Calms down your immune system. Enbrel (Etanercept) is very effective at calming down your immune system, but it's expensive, you have to take into account the hassle of injections and traveling with the medication.Coming soon.
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Coupons for Enbrel
Best available price for 1 (4 sureclicks of 50mg) carton of etanercept
Coupons for Arava
Best available price for 30 (20mg) tablets of leflunomide
Reviews & ratings
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Reviews for Enbrel (etanercept)
of people (All ages) say Enbrel (etanercept) is worth it
say it works well
say it's a big hassle
Have you used Enbrel (etanercept)?
Worth itNot sureNot worth it
Reviews for Arava (leflunomide)
Not enough review data. Review it!
+38% better vs. Enbrel (etanercept)
Not enough review data. Review it!
-3% worse vs. Enbrel (etanercept)
Not enough review data. Review it!
+17% better vs. Enbrel (etanercept)
Have you used Arava (leflunomide)?
Worth itNot sureNot worth it
Side effects
  • Positive anti-double-stranded dna antibodies 11%
  • Antibodies to etanercept 6%
  • Crithidia luciliae 3%
  • Anticardiolipin 3%
  • Mild or moderate skin reactions 15%
  • Any infection 11%
  • Upper respiratory infections 8%
  • Injection site reactions 26%
  • Non-upper respiratory infections 6%
  • Positive ana 6%
More Enbrel side effects »

We haven’t found good data for Arava side effects.

FDA side effect reports for Arava »
How it works
Enbrel (Etanercept) is a biologic response modifier. It works in the immune system to block a protein called TNF (tumor necrosis factor). Blocking TNF relieves symptoms and prevents disease progression.Coming soon.
Type of medication
Prescription only
Available as
  • Injection
  • Pill
Used for
  • Rheumatoid Arthritis
Risk factors for serious side effects
  • History of heart failure
  • Taking other immunosuppressant drugs
  • Age 60 or older
  • History of malignancy
Detailed Enbrel (etanercept) risks & warnings »
    Coming soon.

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    Upsides and benefits
    • Treats certain types of arthritis conditions caused by an overactive immune system.
    • Enbrel is the first biologic approved for moderate to severe rheumatoid arthritis.
    • It has an established safety profile for treatment of rheumatoid arthritis (RA).
    • Available as a single-use syringe and SureClick auto-injector pen which may be more convenient and easier for some people to use.
    • People taking Enbrel for rheumatoid arthritis showed significant improvement and were able to reduce the dose or stop immunosuppressant medicines.
    Coming soon
    Downsides and risks
    • It's an injection.
    • It's expensive because there's no generic available yet.
    • Enbrel lowers your ability to fight infection and can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
    • You're first dose of Enbrel will need to be given at your doctor's office. If you decide not to self-inject and don't have someone to do it for you, you'll need to continue to see your doctor for each dose.
    • You'll need to properly dispose of the needle, syringes, or Pen in a special (FDA-approved) sharps container.
    • Because it needs to be refrigerated until you use it, if you're traveling, you'll need to carry it in a cooler with an ice pack.
    Coming soon
    Tips from our pharmacists for people taking the medication
    • Enbrel (Etanercept) is available as a single-use prefilled syringe, single-use prefilled SureClick Autoinjector, and multiple-use vial. You and your doctor can discuss which is best for you.
    • The autoinjector can be stored at room temperature for up to 14 days and can't be refrigerated again.
    • Enbrel (Etanercept) is a medication that's injected under the skin (subcutaneous). Your doctor can give you your first dose, then let you self-inject it once so you learn how to do it correctly.
    • Enbrel (Etanercept) lowers the your immune system's ability to fight infections, so it's important to let your doctor know if you come down with a fever, cough, or notice flu-like symptoms.
    • You'll need to have a TB test before you start using Enbrel (Etanercept).
    • Tell your doctor if you have an allergy to latex since the syringe needle cover has latex in it.
    • Don't inject Enbrel (Etanercept) into skin that's red, bruised, or irritated. Rotate your injection areas to avoid skin reactions.
    • As with all injection medicines, store away from children and throw used syringes away in a protective container, and not in the trash.
    Coming soon
    Learn more
    More about EnbrelSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Enbrel (etanercept)?
    Worth itNot sureNot worth it
    More about AravaSide effectsReviews & ratingsFDA package insert
    Have you used Arava (leflunomide)?
    Worth itNot sureNot worth it