Compare Enbrel vs. Cyclosporine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Coming soon.

Enbrel
(Etanercept)

Neoral
(Cyclosporine)

Calms down your immune system. Enbrel (Etanercept) is very effective at calming down your immune system, but it's expensive, you have to take into account the hassle of injections and traveling with the medication.Coming soon.
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Reviews & ratings
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4.99Enbrel
Reviews for Enbrel (Etanercept)
62%
of people (All ages) say Enbrel (Etanercept) is worth it
53%
say it works well
17%
say it's a big hassle
Have you used Enbrel (Etanercept)?
Worth itNot sureNot worth it

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Have you used Neoral (Cyclosporine)?
Worth itNot sureNot worth it
Side effects
EnbrelCyclosporine

The Enbrel FDA package insert doesn’t have numbers about how common side effects are.

More about Enbrel side effects »

We haven’t found good data for Cyclosporine side effects.

FDA side effect reports for Cyclosporine »
How it works
EnbrelCyclosporine
Enbrel (Etanercept) is a biologic response modifier. It works in the immune system to block a protein called TNF (tumor necrosis factor). Blocking TNF relieves symptoms and prevents disease progression.Coming soon.
Type of medication
EnbrelCyclosporine
Immunosuppressant
Immunomodulator
Antirheumatic
Biological response modifier
Prescription only
Coming soon.
Available as
EnbrelCyclosporine
  • Injection
  • Pill
  • Liquid
Used for (click to learn more)
EnbrelCyclosporine
  • Cardiac transplant rejection; Prophylaxis Liver transplant rejection; Prophylaxis Plaque psoriasis (Severe)
Risk factors for serious side effects
EnbrelCyclosporine
  • History of heart failure
  • Taking other immunosuppressant drugs
  • Age 60 or older
  • History of malignancy
  • History of neurologic condition
Detailed risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Upsides and benefits
EnbrelCyclosporine
  • Treats certain types of arthritis conditions caused by an overactive immune system.
  • Enbrel is the first biologic approved for moderate to severe rheumatoid arthritis.
  • It has an established safety profile for treatment of rheumatoid arthritis (RA).
  • Available as a single-use syringe and SureClick auto-injector pen which may be more convenient and easier for some people to use.
  • People taking Enbrel for rheumatoid arthritis showed significant improvement and were able to reduce the dose or stop immunosuppressant medicines.
Coming soon
Downsides and risks
EnbrelCyclosporine
  • It's an injection.
  • It's expensive because there's no generic available yet.
  • Enbrel lowers your ability to fight infection and can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
  • You're first dose of Enbrel will need to be given at your doctor's office. If you decide not to self-inject and don't have someone to do it for you, you'll need to continue to see your doctor for each dose.
  • You'll need to properly dispose of the needle, syringes, or Pen in a special (FDA-approved) sharps container.
  • Because it needs to be refrigerated until you use it, if you're traveling, you'll need to carry it in a cooler with an ice pack.
Coming soon
Tips from our pharmacists for people taking the medication
EnbrelCyclosporine
  • Enbrel (Etanercept) is available as a single-use prefilled syringe, single-use prefilled SureClick Autoinjector, and multiple-use vial. You and your doctor can discuss which is best for you.
  • The autoinjector can be stored at room temperature for up to 14 days and can't be refrigerated again.
  • Enbrel (Etanercept) is a medication that's injected under the skin (subcutaneous). Your doctor can give you your first dose, then let you self-inject it once so you learn how to do it correctly.
  • Enbrel (Etanercept) lowers the your immune system's ability to fight infections, so it's important to let your doctor know if you come down with a fever, cough, or notice flu-like symptoms.
  • You'll need to have a TB test before you start using Enbrel (Etanercept).
  • Tell your doctor if you have an allergy to latex since the syringe needle cover has latex in it.
  • Don't inject Enbrel (Etanercept) into skin that's red, bruised, or irritated. Rotate your injection areas to avoid skin reactions.
  • As with all injection medicines, store away from children and throw used syringes away in a protective container, and not in the trash.
Coming soon
Learn more
More about EnbrelSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Enbrel (Etanercept)?
Worth itNot sureNot worth it
More about CyclosporineSide effectsReviews & ratingsFDA package insert
Have you used Neoral (Cyclosporine)?
Worth itNot sureNot worth it