Compare Enbrel vs. Humira

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Enbrel
(Etanercept)

Humira
(Adalimumab)

Calms down your immune system. Enbrel (Etanercept) is very effective at calming down your immune system, but it's expensive, you have to take into account the hassle of injections and traveling with the medication.Calms down your immune system. Humira (Adalimumab) is very effective at calming down your immune system, but it's expensive, you have to take into account the hassle of injections and traveling with the medication.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.924050632911392Enbrel
Reviews for Enbrel (Etanercept)
58%
of people say Enbrel (Etanercept) is worth it
52%
say it works well
19%
say it's a big hassle
Reviews for Humira (Adalimumab)
59%
+1% vs. Enbrel (Etanercept)
49%
3% vs. Enbrel (Etanercept)
26%
7% vs. Enbrel (Etanercept)
Side effects
EnbrelHumira
  • Injection site reactions 26%
  • Any infection 11%
  • Positive anti-double-stranded dna antibodies 11%
  • Upper respiratory infections 8%
  • Non-upper respiratory infections 6%
  • Positive ana 6%
  • Itching 1%
  • Rash 1%
More Enbrel side effects »
  • Injection site reactions 6%
  • Rash 6%
  • Positive titers 5%
  • Upper respiratory infection 4%
  • Headache 4%
  • Abdominal pain 3%
  • Urinary tract infection 3%
  • High blood pressure 2%
  • Alkaline phosphatase increased 2%
  • High blood lipid levels 2%
More Humira side effects »
How it works
EnbrelHumira
Enbrel (Etanercept) is a biologic response modifier. It works in the immune system to block a protein called TNF (tumor necrosis factor). Blocking TNF relieves symptoms and prevents disease progression.Humira (Adalimumab) is a biologic response modifier. It works in the immune system to block a protein called TNF (tumor necrosis factor). Blocking TNF relieves symptoms and prevents disease progression.
Type of medication
EnbrelHumira
Immunosuppressant
Immunomodulator
Antirheumatic
Biological response modifier
Prescription only
Immunosuppressant
Immunomodulator
Antirheumatic
Biological response modifier
Prescription only
Available as
EnbrelHumira
  • Injection
  • Injection
Used for (click to learn more)
EnbrelHumira
Risk factors for serious side effects
EnbrelHumira
    • History of heart failure
    • Taking other immunosuppressant drugs
    • Age 60 or older
    • Taking other immunosuppressant drugs
    • History of malignancy
    • History of neurologic condition
      Detailed Enbrel (Etanercept) risks & warnings »
        • History of heart failure
        • Taking other immunosuppressant drugs
        • Age 60 or older
        • Taking other immunosuppressant drugs
        • History of malignancy
        • History of neurologic condition
          Detailed Humira (Adalimumab) risks & warnings »
          Pregnancy category
          EnbrelHumira
          Alcohol
          No specific alcohol-related info.No specific alcohol-related info.
          Food
          No specific food-related info.No specific food-related info.
          Kidneys and liver
          No specific kidneys and liver-related info.No specific kidneys and liver-related info.
          Sex
          No specific sex-related info.No specific sex-related info.
          Sleep
          No specific sleep-related info.No specific sleep-related info.
          Weight
          • Enbrel (Etanercept) can increase your risk of serious or life-threatening bacterial, fungal and viral infections. In some cases infections can be reactivated from an inactive virus in your body like tuberculosis (TB) or hepatitis B virus (HBV). You may need to take medicine for TB before you can begin taking Enbrel (Etanercept). If you develop symptoms of cough, fever, chills, muscle aches, feel very tired, or you notice dark urine, yellowing of skin/eyes, appetite/weight loss, vomiting, change in stool color, stomach discomfort, and skin rash, tell your doctor and get medical care right away.
          • Humira (Adalimumab) can increase your risk of serious or life-threatening bacterial, fungal and viral infections. In some cases infections can be reactivated from an inactive virus in your body like tuberculosis (TB) or hepatitis B virus (HBV). You may need to take medicine for TB before you can begin taking Humira (Adalimumab). If you develop symptoms of cough, fever, chills, muscle aches, feel very tired, or you notice dark urine, yellowing of skin/eyes, appetite/weight loss, vomiting, change in stool color, stomach discomfort, and skin rash, tell your doctor and get medical care right away.
          Upsides and benefits
          EnbrelHumira
          • Treats certain types of arthritis conditions caused by an overactive immune system.
          • Enbrel is the first biologic approved for moderate to severe rheumatoid arthritis.
          • It has an established safety profile for treatment of rheumatoid arthritis (RA).
          • Available as a single-use syringe and SureClick auto-injector pen which may be more convenient and easier for some people to use.
          • People taking Enbrel for rheumatoid arthritis showed significant improvement and were able to reduce the dose or stop immunosuppressant medicines.
          • Treats certain types of arthritis and gastrointestinal conditions caused by an overactive immune system.
          • Most people feel it's worth the hassle.
          • Once you've learned the correct way to use Humira, you can inject the medicine yourself without going to your doctor's office.
          • It's available in a single-use pen (Humira Pen) that may be more convenient and easier for some people to use.
          • It's an alternative for people with Crohn's disease who stopped getting better on other TNF-blockers or had side effects that made them switch.
          Downsides and risks
          EnbrelHumira
          • Enbrel lowers your ability to fight infection and can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
          • You're first dose of Enbrel will need to be given at your doctor's office. If you decide not to self-inject and don't have someone to do it for you, you'll need to continue to see your doctor for each dose.
          • It's an injection.
          • It's expensive because there's no generic available yet.
          • You'll need to properly dispose of the needle, syringes, or Pen in a special (FDA-approved) sharps container.
          • Because it needs to be refrigerated until you use it, if you're traveling, you'll need to carry it in a cooler with an ice pack.
          • Humira lowers your ability to fight infection and can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
          • You're first dose of Humira will need to be given at your doctor's office. If you decide not to self-inject and don't have someone to do it for you, you'll need to continue to see your doctor for each dose.
          • It's an injection.
          • It's expensive because there's no generic available yet.
          • You'll need to properly dispose of the needle, syringes, or Pen in a special (FDA-approved) sharps container.
          • Because it needs to be refrigerated until you use it, if you're traveling, you'll need to carry it in a cooler with an ice pack.
          Tips from our pharmacists for people taking the medication
          EnbrelHumira
          • Enbrel (Etanercept) is available as a single-use prefilled syringe, single-use prefilled SureClick Autoinjector, and multiple-use vial. You and your doctor can discuss which is best for you.
          • The autoinjector can be stored at room temperature for up to 14 days and can't be refrigerated again.
          • Enbrel (Etanercept) is a medication that's injected under the skin (subcutaneous). Your doctor can give you your first dose, then let you self-inject it once so you learn how to do it correctly.
          • Enbrel (Etanercept) lowers the your immune system's ability to fight infections, so it's important to let your doctor know if you come down with a fever, cough, or notice flu-like symptoms.
          • You'll need to have a TB test before you start using Enbrel (Etanercept).
          • Don't inject Enbrel (Etanercept) into skin that's red, bruised, or irritated. Rotate your injection areas to avoid skin reactions.
          • Tell your doctor if you have an allergy to latex since the syringe needle cover has latex in it.
          • As with all injection medicines, store away from children and throw used syringes away in a protective container, and not in the trash.
          • Humira (Adalimumab) is a medication that's injected under the skin (subcutaneous). Your doctor can give you your first dose, then let you self-inject it once so you learn how to do it correctly.
          • Humira (Adalimumab) lowers the your immune system's ability to fight infections, so it's important to let your doctor know if you come down with a fever, cough, or notice flu-like symptoms.
          • You'll need to have a TB test before you start using Humira (Adalimumab).
          • Don't inject Humira (Adalimumab) into skin that's red, bruised, or irritated. Rotate your injection areas to avoid skin reactions.
          • Tell your doctor if you have an allergy to latex since the syringe needle cover has latex in it.
          • As with all injection medicines, store away from children and throw used syringes away in a protective container, and not in the trash.
          Learn more
          More about EnbrelSide effectsReviews & ratingsAlternativesFDA package insert
          More about HumiraSide effectsReviews & ratingsAlternativesFDA package insert