Compare Enbrel vs. Humira

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Enbrel (etanercept)

Prescription only

Humira (adalimumab)

Prescription only
Calms down your immune system to prevent joint damage.

Enbrel (etanercept) effectively calms down your immune system, but it puts you at risk of serious infections.

3.7/ 5 average rating with 90 reviewsforEnbrel
Calms down the immune system.

Humira (adalimumab) is good for treating many autoimmune conditions, but it can also cause serious side effects.

3.6/ 5 average rating with 182 reviewsforHumira
Upsides
  • People taking Enbrel (etanercept) for rheumatoid arthritis showed significant improvement and were able to reduce the dose or stop their other RA medicines.
  • Enbrel (etanercept) can work for you even if other medications didn't help your rheumatoid arthritis.
  • Enbrel (etanercept) is the first biologic approved for moderate to severe rheumatoid arthritis. Since it has been around for a long time, its side effects are well known.
  • Many people have only minor or no side effects.
  • It's available as a pre-filled syringe and SureClick auto-injector pen which some people find more convenient and easier to use.
  • Humira (adalimumab) is effective in reducing symptoms in all of its approved indications.
  • You can give yourself Humira (adalimumab) on your own at home rather than visiting a clinic or hospital.
  • Humira (adalimumab) treats many different autoimmune conditions.
  • Available in a single-use pen (Humira Pen) that may be more convenient and easier for some people to use.
Downsides
  • Enbrel (etanercept) raises your risk of serious or life-threatening infections, including tuberculosis (TB).
  • Enbrel (etanercept) can increase the risk of lymphoma, leukemia and other cancers.
  • May not be the best choice if you have a history of heart failure or nervous system problems like multiple sclerosis.
  • You'll need to have regular blood tests before and during treatment to make sure you don't have any problems taking Enbrel (etanercept).
  • You could get injection site reactions such as redness, swelling, rash, itching, or bruising.
  • Not first-choice treatment for rheumatoid arthritis.
  • Humira (adalimumab) is an injection and not an oral medication.
  • Humira (adalimumab) is expensive because there's no generic available yet.
  • Humira (adalimumab) lowers your ability to fight infection and in some cases can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
  • You'll need to properly dispose of the needle, syringes, or Pen in a sharps container.
  • Humira (adalimumab) needs to be refrigerated until you use it, so if you're traveling, you'll need to carry it in a cooler with an ice pack.
Used for
Dosage forms
  • Injection
  • Injection
Price
Lowest price
$4537.83
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Lowest price
$4537.05
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Reviews
90 reviews so far
62%
saidit'sworth it
53%
saiditworked well
17%
saidit'sa big hassle

Have you used Enbrel (etanercept)?

Leave a review
182 reviews so far
60%
saidit'sworth it
51%
saiditworked well
26%
saidit'sa big hassle

Have you used Humira (adalimumab)?

Leave a review
Side effects
5possible side effects
  • Any infection
    27%
  • Upper respiratory infections
    17%
  • Injection site reactions
    15%
  • Non-upper respiratory infections
    12%
  • Diarrhea
    3%
See more detailed side effects
14possible side effects
  • Upper airway infection
    17%
  • Headache
    12%
  • Rash
    12%
  • Sinus infection
    11%
  • Nausea
    9%
  • Injection site reactions
    8%
  • Urinary tract infection
    8%
  • Flu syndrome
    7%
  • Stomach pain
    7%
  • High cholesterol
    7%
  • Back pain
    6%
  • Blood in urine
    5%
  • Abnormal liver tests
    5%
  • High blood pressure
    5%
See more detailed side effects
Risks and risk factors
  • Serious allergic reactions
    • Latex allergy
  • Heart problems
    • History of heart failure
  • Serious infections
    • Taking other immunosuppressant drugs
    • Age 65 or older
  • Cancer
    • Taking other immunosuppressant drugs
    • History of cancer
  • Nervous system effects
    • History of nervous system conditions
  • Lower blood cell counts
See more detailed risks and warnings
  • Serious infections
    • Taking other immunosuppressant medications such as Kineret or Orencia
    • Age 65 or older
    • Active, chronic, or recurrent infection
    • Comorbidities
  • Cancers
    • Taking other immunosuppressant medications, such as azathiprine or 6-mercaptopurine, at the same time as Humira (adalimumab)
    • History of malignancy
    • Adolescent age
    • COPD with significant smoking history
  • Serious allergic reactions
  • Heart problems
    • History of heart failure
  • Nervous system effects
    • Preexisting or recently acquired neurologic condition
  • Lower blood cell counts
See more detailed risks and warnings