Compare Enbrel vs. Imbruvica

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Enbrel
(etanercept)

Imbruvica
(ibrutinib)

Calms down your immune system to prevent joint damage. Enbrel (etanercept) effectively calms down your immune system, but it puts you at risk of serious infections.Coming soon.
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Coupons for Enbrel
Best available price for 3.92 (4 sureclicks of 50mg) cartons of enbrel
Coupons for Imbruvica
Best available price for 90 (90 capsules of 140mg) bottles of ibrutinib
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.99Enbrel
Reviews for Enbrel
62%
of people (All ages) say Enbrel is worth it
53%
say it works well
17%
say it's a big hassle
Have you used Enbrel (etanercept)?
Worth itNot sureNot worth it

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Have you used Imbruvica (ibrutinib)?
Worth itNot sureNot worth it
Side effects
EnbrelImbruvica
  • Infections 11%
  • Upper airway infections 8%
  • Injection site reactions 26%
  • Non-upper respiratory infections 6%
  • Rash 1%
  • Fever 3%
  • Itchiness 1%
More Enbrel side effects »

We haven’t found good data for Imbruvica side effects.

FDA side effect reports for Imbruvica »
How it works
EnbrelImbruvica
Enbrel (etanercept) blocks a protein called TNF (tumor necrosis factor) in the immune system which lowers inflammation, relieves symptoms and prevents disease progression.Coming soon.
Type of medication
EnbrelImbruvica
Prescription only
Available as
EnbrelImbruvica
  • Injection
  • Pill
Used for
EnbrelImbruvica
  • Chronic Lymphoid Leukemia
Risk factors for serious side effects
EnbrelImbruvica
  • Latex allergy
  • History of heart failure
  • Taking other immunosuppressant drugs
  • Age 65 or older
Detailed Enbrel (etanercept) risks & warnings »
    Coming soon.
    Pregnancy

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Upsides and benefits
    EnbrelImbruvica
    • People taking Enbrel (etanercept) for rheumatoid arthritis showed significant improvement and were able to reduce the dose or stop their other RA medicines.
    • Enbrel (etanercept) can work for you even if other medications didn't help your rheumatoid arthritis.
    • Enbrel (etanercept) is the first biologic approved for moderate to severe rheumatoid arthritis. Since it has been around for a long time, its side effects are well known.
    • Many people have only minor or no side effects.
    • It's available as a pre-filled syringe and SureClick auto-injector pen which some people find more convenient and easier to use.
    Coming soon
    Downsides and risks
    EnbrelImbruvica
    • Enbrel (etanercept) raises your risk of serious or life-threatening infections, including tuberculosis (TB).
    • Enbrel (etanercept) can increase the risk of lymphoma, leukemia and other cancers.
    • May not be the best choice if you have a history of heart failure or nervous system problems like multiple sclerosis.
    • You'll need to have regular blood tests before and during treatment to make sure you don't have any problems taking Enbrel (etanercept).
    • You could get injection site reactions such as redness, swelling, rash, itching, or bruising.
    Coming soon
    Tips from our pharmacists for people taking the medication
    EnbrelImbruvica
    • Enbrel (etanercept) is available as an injection and a SureClick Autoinjector. You and your doctor can discuss which is best for you.
    • Enbrel (etanercept) is a medication that's injected under the skin (subcutaneous). Your doctor can give you your first dose, then let you self-inject it once you learn how to do it correctly.
    • Enbrel (etanercept) lowers your immune system's ability to fight infections including tuberculosis (TB), fungal, viral, and bacterial infections. Your doctor will check for TB and hepatitis B before starting Enbrel (etanercept). Let your doctor know if you come down with a fever, cough, or notice flu-like symptoms before or during treatment.
    • Enbrel (etanercept) can cause redness, rash, swelling, itching, or bruising at the site of injection. Do not inject into skin that's already red, bruised, or irritated. Rotate your injection areas to avoid skin reactions.
    • Keep Enbrel (etanercept) refrigerated, but let it rest at room temperature for 30 to 60 minutes before using it. Enbrel (etanercept) should not be used if kept at room temperature for longer than 14 days.
    • You should not receive certain vaccinations with Enbrel (etanercept). Discuss with your doctor about your vaccine history and whether you need to receive any vaccines before treatment.
    Coming soon
    Learn more
    More about EnbrelSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Enbrel (etanercept)?
    Worth itNot sureNot worth it
    More about ImbruvicaSide effectsReviews & ratingsFDA package insert
    Have you used Imbruvica (ibrutinib)?
    Worth itNot sureNot worth it