Compare Enbrel vs. Orencia
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Calms down your immune system to prevent joint damage.
Enbrel (etanercept) effectively calms down your immune system, but it puts you at risk of serious infections.
3.7/ 5 average rating with 90 reviewsforEnbrel
Calms down the immune system and prevents joint damage.
Orencia (abatacept) slows the progress of rheumatoid arthritis, but can also cause serious side effects.
- People taking Enbrel (etanercept) for rheumatoid arthritis showed significant improvement and were able to reduce the dose or stop their other RA medicines.
- Enbrel (etanercept) can work for you even if other medications didn't help your rheumatoid arthritis.
- Enbrel (etanercept) is the first biologic approved for moderate to severe rheumatoid arthritis. Since it has been around for a long time, its side effects are well known.
- Many people have only minor or no side effects.
- It's available as a pre-filled syringe and SureClick auto-injector pen which some people find more convenient and easier to use.
- In a 2-year study that used IV Orencia (abatacept) with methotrexate, more than half of the people had remission and the majority felt significantly better.
- Helps minimize joint damage, lowers symptoms, and prevents future problems. People taking Orencia (abatacept) had no new joint damage after two years.
- Taking Orencia (abatacept) allows RA patients to use less prednisone, a steroid that has many side effects.
- You can give yourself Orencia (abatacept) subcutaneously on your own at home rather than visiting a clinic or hospital.
- Available in a prefilled autoinjector for convenient use.
- Enbrel (etanercept) raises your risk of serious or life-threatening infections, including tuberculosis (TB).
- Enbrel (etanercept) can increase the risk of lymphoma, leukemia and other cancers.
- May not be the best choice if you have a history of heart failure or nervous system problems like multiple sclerosis.
- You'll need to have regular blood tests before and during treatment to make sure you don't have any problems taking Enbrel (etanercept).
- You could get injection site reactions such as redness, swelling, rash, itching, or bruising.
- Orencia (abatacept) can be costly.
- The IV infusion form of Orencia (abatacept) can cause a reaction, which ranges from a slight itching or warm feeling to more serious side effects such as low blood pressure and chest pain.
- The IV infusion form of Orencia (abatacept) contains maltose, a type of sugar, that can give false high blood sugar readings with certain types of blood sugar monitors on the day of Orencia (abatacept) infusion. The self-injection subcutaneous form does not contain maltose. Talk to your doctor if you have diabetes.
- If you need TNF inhibitors as part of your treatment, it is not recommended to take Orencia (abatacept). If you have COPD, you are at higher risk of side effects.
- Orencia (abatacept) lowers your ability to fight infection. Your risk can increase if you take medications that lower your immune system or have an active infection. You may need to get tested for tuberculosis before starting Orencia (abatacept).
- Rheumatoid Arthritis
- Polyarticular Juvenile Idiopathic Arthritis
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90 reviews so far
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5possible side effects
- Any infection27%
- Upper respiratory infections17%
- Injection site reactions15%
- Non-upper respiratory infections12%
10possible side effects
- Common cold12%
- Back pain7%
- High blood pressure7%
- Urinary tract infection6%
- Pain in arms or legs3%
Risks and risk factors
- Serious allergic reactions
- Latex allergy
- Heart problems
- History of heart failure
- Serious infections
- Taking other immunosuppressant drugs
- Age 65 or older
- Taking other immunosuppressant drugs
- History of cancer
- Nervous system effects
- History of nervous system conditions
- Lower blood cell counts
- High risk of infections with TNF inhibitors
- Using TNF inhibitors
- Severe allergic reactions
- Lower effectiveness of vaccines
- Immunosuppression and Infections
- Taking immunosuppressive medications
- History of repeat infections
- Adults with rheumatoid arthritis taking TNF inhibitors
- More COPD side effects