Compare Enbrel vs. Rituxan

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Enbrel (etanercept)

Prescription only

Rituxan (Rituximab)

Prescription only
Calms down your immune system to prevent joint damage.

Enbrel (etanercept) effectively calms down your immune system, but it puts you at risk of serious infections.

5.0/ 7 average rating with 90 reviewsforEnbrel
Calms down your immune system.

Rituxan (Rituximab) is effective for treating multiple types of cancer and arthritis. That said, you'll need to watch for possibly serious side effects, especially infusion reactions.

Upsides
  • People taking Enbrel (etanercept) for rheumatoid arthritis showed significant improvement and were able to reduce the dose or stop their other RA medicines.
  • Enbrel (etanercept) can work for you even if other medications didn't help your rheumatoid arthritis.
  • Enbrel (etanercept) is the first biologic approved for moderate to severe rheumatoid arthritis. Since it has been around for a long time, its side effects are well known.
  • Many people have only minor or no side effects.
  • It's available as a pre-filled syringe and SureClick auto-injector pen which some people find more convenient and easier to use.
  • Treats leukemia, lymphoma, and blood vessel inflammation.
  • Also treats moderate to severe rheumatoid arthritis that hasn't responded to anti-TNF treatment (but you'll need to take methotrexate too).
  • The chance of having a reaction to the infusion is highest during your first dose, but the risk decreases each time you get Rituxan (Rituximab). It usually happens within 30 minutes to 2 hours after starting the infusion.
  • Rituxan (Rituximab) is a targeted therapy that works differently than chemotherapy. Both work well when they're taken together, especially when treating CLL and NHL.
Downsides
  • Enbrel (etanercept) raises your risk of serious or life-threatening infections, including tuberculosis (TB).
  • Enbrel (etanercept) can increase the risk of lymphoma, leukemia and other cancers.
  • May not be the best choice if you have a history of heart failure or nervous system problems like multiple sclerosis.
  • You'll need to have regular blood tests before and during treatment to make sure you don't have any problems taking Enbrel (etanercept).
  • You could get injection site reactions such as redness, swelling, rash, itching, or bruising.
  • Only your doctor or other trained medical staff can administer Rituxan (Rituximab), so you'll need to go into an office or clinic for every dose.
  • Not the best choice if you have heart problems.
  • Rituxan (Rituximab) can stay in your body for up to 6 months after you complete treatment. Men and women who are able to have children need to use birth control for up to one year after finishing Rituxan (Rituximab).
  • Discuss with your doctor the serious heart, kidney, liver, or stomach problems that can happen while on Rituxan (Rituximab).
Used for
Dosage forms
  • Injection
  • Infusion (iv)
Price
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$4537.83
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Reviews
90 
62%
think this treatment is worth it
53%
think this treatment works well
17%
think this treatment is a hassle

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Side effects
5possible side effects
  • Any infection
    27%
  • Upper respiratory infections
    17%
  • Injection site reactions
    15%
  • Non-upper respiratory infections
    12%
  • Diarrhea
    3%
See more detailed side effects
4possible side effects
  • Any infection
    62%
  • Infusion reaction
    12%
  • Any serious infection
    11%
  • Cardiac side effect
    2%
See more detailed side effects
Risks and warnings
  • Serious allergic reactions

    Latex allergy

  • Heart problems

    History of heart failure

  • Serious infections

    Taking other immunosuppressant drugs

    ...and 1 more risk factors

  • Cancer

    Taking other immunosuppressant drugs

    ...and 1 more risk factors

  • Nervous system effects

    History of nervous system conditions

See more detailed risks and warnings
  • Serious infections

    Taking other immunosuppressant drugs

    ...and 2 more risk factors

  • Nervous system effects

    Taking Rituxan (Rituximab) with immunosuppressant drugs (if using for RA)

    ...and 2 more risk factors

  • Kidney injury

    Taking Rituxan (Rituximab) for Non-Hodgkin's Lymphoma (NHL)

    ...and 1 more risk factors

  • Heart problems

    History of heart problems

    ...and 1 more risk factors

  • Gastrointestinal problems

    Start of therapy with Rituxan (Rituximab)

See more detailed risks and warnings