Compare Enbrel vs. Stelara

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Enbrel (etanercept)

Prescription only

Stelara (Ustekinumab)

Prescription only
Calms down your immune system to prevent joint damage.

Enbrel (etanercept) effectively calms down your immune system, but it puts you at risk of serious infections.

5.0/ 7 average rating with 90 reviewsforEnbrel
Treats moderate to severe psoriasis.

Stelara (Ustekinumab) works for two psoriatic conditions. It may be somewhat of a hassle because of the injection, but after the first two doses, you only need to take it every 12 weeks.

4.2/ 7 average rating with 50 reviewsforStelara
Upsides
  • People taking Enbrel (etanercept) for rheumatoid arthritis showed significant improvement and were able to reduce the dose or stop their other RA medicines.
  • Enbrel (etanercept) can work for you even if other medications didn't help your rheumatoid arthritis.
  • Enbrel (etanercept) is the first biologic approved for moderate to severe rheumatoid arthritis. Since it has been around for a long time, its side effects are well known.
  • Many people have only minor or no side effects.
  • It's available as a pre-filled syringe and SureClick auto-injector pen which some people find more convenient and easier to use.
  • Stelara (Ustekinumab) works throughout your whole body (systemic therapy) and may be better than just applying medicine to your skin (local therapy) for moderate or severe plaque psoriasis that covers large areas or many areas of your body.
  • It's used alone or together with another medicine called methotrexate for better results to treat active psoriatic arthritis.
  • Initial dosing might be a hassle, but then you only have to take it every 12 weeks.
  • People treated with Stelara (Ustekinumab) for psoriatic arthritis felt better and had more physical improvement compared to not using the medicine (placebo).
Downsides
  • Enbrel (etanercept) raises your risk of serious or life-threatening infections, including tuberculosis (TB).
  • Enbrel (etanercept) can increase the risk of lymphoma, leukemia and other cancers.
  • May not be the best choice if you have a history of heart failure or nervous system problems like multiple sclerosis.
  • You'll need to have regular blood tests before and during treatment to make sure you don't have any problems taking Enbrel (etanercept).
  • You could get injection site reactions such as redness, swelling, rash, itching, or bruising.
  • It's an injection.
  • Stelara (Ustekinumab) lowers your ability to fight infection and can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
  • You have to get your first dose of Stelara (Ustekinumab) at your doctor's office. If you decide not to self-inject and don't have someone to do it for you, you'll need to continue to see your doctor for each dose.
  • You'll need to properly dispose of the needle and syringes in a special (FDA-approved) sharps container.
  • Because Stelara (Ustekinumab) needs to be refrigerated until you use it, if you're traveling, you'll need to carry it in a cooler with an ice pack.
Used for
Dosage forms
  • Injection
  • Injection
Price
Lowest price near you
$4537.83
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$9736.36
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Reviews
90 
62%
think this treatment is worth it
53%
think this treatment works well
17%
think this treatment is a hassle

Have you used Enbrel (etanercept)?

Leave a review
50 
48%
think this treatment is worth it
42%
think this treatment works well
20%
think this treatment is a hassle

Have you used Stelara (Ustekinumab)?

Leave a review
Side effects
5possible side effects
  • Any infection
    27%
  • Upper respiratory infections
    17%
  • Injection site reactions
    15%
  • Non-upper respiratory infections
    12%
  • Diarrhea
    3%
See more detailed side effects
1possible side effects
  • Immunogenicity
    6%
See more detailed side effects
Risks and warnings
  • Serious allergic reactions

    Latex allergy

  • Heart problems

    History of heart failure

  • Serious infections

    Taking other immunosuppressant drugs

    ...and 1 more risk factors

  • Cancer

    Taking other immunosuppressant drugs

    ...and 1 more risk factors

  • Nervous system effects

    History of nervous system conditions

See more detailed risks and warnings
  • Serious Infections

    Taking other immunosuppressant drugs

    ...and 2 more risk factors

  • Malignancy

    Age 60 or older

    ...and 2 more risk factors

  • Nervous system effects

    Preeclampsia/eclampsia

    ...and 3 more risk factors

See more detailed risks and warnings