Compare Endometrin vs. Aygestin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Endometrin
(Progesterone Vaginal Insert)

Aygestin
(Norethindrone)

Supports fertility treatments. Endometrin (Progesterone Vaginal Insert) is a vaginal insert used in fertility treatments, but you have to apply it more often than progesterone vaginal gel.Regulates your menstrual cycle and treats irregular bleeding. Aygestin (Norethindrone) regulates the menstrual cycle and treats heavy vaginal bleeding. It's easy to take and isn't expensive.
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Reviews & ratings
Button Group. All currently active
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3.963636363636364Endometrin
Reviews for Endometrin (Progesterone Vaginal Insert)
45%
of people say Endometrin (Progesterone Vaginal Insert) is worth it
20%
say it works well
27%
say it's a big hassle
Reviews for Aygestin (Norethindrone)
40%
5% vs. Endometrin (Progesterone Vaginal Insert)
23%
+3% vs. Endometrin (Progesterone Vaginal Insert)
23%
+4% vs. Endometrin (Progesterone Vaginal Insert)
Side effects
EndometrinAygestin

The Endometrin FDA package insert doesn’t have numbers about how common side effects are.

More about Endometrin side effects »

We haven’t found good data for Aygestin side effects.

FDA side effect reports for Aygestin »
How it works
EndometrinAygestin
Endometrin (Progesterone Vaginal Insert) contains progesterone, one of the hormones essential for maintaining a pregnancy. Women on fertility treatment can take progesterone to prepare the lining of the uterus to receive and nourish a fertilized egg.Aygestin (Norethindrone) contains norethindrone, a progestin, which is a synthetic progesterone hormone. It regulates your period, treats irregular vaginal bleeding, and eases the pain of endometriosis (a condition where tissue that lines your uterus is found in other parts of the body).
Type of medication
EndometrinAygestin
ProgestinPrescription only
ProgestinPrescription only
Available as
EndometrinAygestin
  • Vaginal insert
  • Pill
Used for (click to learn more)
EndometrinAygestin
  • Female infertility
  • Amenorrhea
Risk factors for serious side effects
EndometrinAygestin
  • Personal or family history of breast cancer
  • Family history of ovarian cancer
  • Personal or family history of blood clots
  • Smoking
  • Obesity
  • Hypertension
  • Diabetes
  • High cholesterol
  • Systemic lupus erythematosus (SLE)
  • Diabetes
  • Heart failure
  • Kidney problems
  • Obesity
Detailed Endometrin (Progesterone Vaginal Insert) risks & warnings »
  • Personal or family history of breast cancer
  • Personal or family history of blood clots
  • Smoking
  • Obesity
  • Hypertension
  • Diabetes
  • High cholesterol
  • Systemic lupus erythematosus (SLE)
  • History of depression
  • Diabetes
  • History of liver problems
  • High cholesterol levels
  • Women of childbearing age
Detailed Aygestin (Norethindrone) risks & warnings »
Pregnancy category
EndometrinAygestin
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
XFDA pregnancy category (Unsafe)

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

See the FDA package insert
Alcohol
No specific alcohol-related info.No specific alcohol-related info.
Food
No specific food-related info.No specific food-related info.
Kidneys and liver
No specific kidneys and liver-related info.No specific kidneys and liver-related info.
Sex
No specific sex-related info.No specific sex-related info.
Sleep
No specific sleep-related info.
  • Can cause cramps, bloating, trouble sleeping, acne, weight gain, facial skin discoloration, or irregular periods.
Weight
No specific weight-related info.
  • Can make you gain weight.
  • Can cause cramps, bloating, trouble sleeping, acne, weight gain, facial skin discoloration, or irregular periods.
Upsides and benefits
EndometrinAygestin
  • Helps increase your chances of getting pregnant.
  • Regulates your menstrual cycle.
  • Exposes your body to less hormone compared to progesterone pills or injections.
  • Endometrin (Progesterone Vaginal Insert) replaces low levels of progesterone to prepare the lining of your uterus to receive and nourish a fertilized egg.
  • Endometrin (Progesterone Vaginal Insert) comes with step-by-step instructions and is easy to use. Unlike some progesterone products that make you to lie down when inserting them, Endometrin (Progesterone Vaginal Insert) can be inserted while you are standing, sitting, or lying on your back with your knees bent.
  • Helps to regulate your period.
  • Decreases bleeding from hormone imbalance.
  • Aygestin (Norethindrone) is available as a generic medication, so it costs less.
Downsides and risks
EndometrinAygestin
  • Endometrin (Progesterone Vaginal Insert) can cause vaginal irritation and burning.
  • Inserting the applicator can possibly cause discomfort or infection.
  • Endometrin (Progesterone Vaginal Insert) is dosed 2 to 3 times a day, compared to other progesterone products that are dosed 1 to 2 times a day.
  • You can't use tampons or other vaginal products for at least 6 hours before and 6 hours after taking Endometrin (Progesterone Vaginal Insert).
  • Can make you gain weight.
  • Higher risk of blood clots.
  • Not for people who are post-menopausal, pregnant, or breast-feeding.
Tips from our pharmacists for people taking the medication
EndometrinAygestin
  • Read the information you get in the pharmacy about how to use Endometrin (Progesterone Vaginal Insert). The step-by-step instructions are really helpful to follow.
  • Each vaginal insert applicator is made for a single use and should be thrown away after you use it.
  • The dose of Aygestin (Norethindrone) will be different depending on what you’re using it for, so take it exactly the way your doctor tells you.
  • It's important to take it the same time every day.
  • Talk to your doctor every few months about using the lowest possible dose of Aygestin (Norethindrone). Since there can be a lot of long-term side effects, take it only as long as you need it.
  • If you're taking Aygestin (Norethindrone) to regulate your period, you'll get withdrawal bleeding 3 to 7 days after stopping Aygestin (Norethindrone).
  • Can cause cramps, bloating, trouble sleeping, acne, weight gain, facial skin discoloration, or irregular periods.
  • Tell your doctor about any severe stomach pain or yellowing of your eyes or skin.
  • Get immediate medical help if you have sudden vision changes or one-sided weakness (signs of stroke) or chest pain and trouble breathing (signs of a pulmonary embolism).
Learn more
More about EndometrinSide effectsReviews & ratingsAlternativesFDA package insert
More about AygestinSide effectsReviews & ratingsAlternativesFDA package insert