Compare Endometrin vs. Aygestin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Endometrin
(progesterone vaginal insert)

Aygestin
(norethindrone)

Supports other fertility treatments. Endometrin (progesterone vaginal insert) is a vaginal insert used in fertility treatments, but you have to apply it more often than progesterone vaginal gel.Regulates your menstrual cycle and treats irregular bleeding. Aygestin (norethindrone) regulates the menstrual cycle and treats heavy or irregular vaginal bleeding. It's easy to take and isn't expensive.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
3.96Endometrin
Reviews for Endometrin
45%
of people (All ages) say Endometrin is worth it
20%
say it works well
27%
say it's a big hassle
Have you used Endometrin (progesterone vaginal insert)?
Worth itNot sureNot worth it
Reviews for Aygestin
40%
+5% better vs. Endometrin
23%
-3% worse vs. Endometrin
23%
-4% worse vs. Endometrin
Have you used Aygestin (norethindrone)?
Worth itNot sureNot worth it
Side effects
EndometrinAygestin
  • Constipation 2%
  • Fatigue 2%
  • Bladder infection 2%
  • Vomiting 3%
  • Vaginal bleeding 3%
  • Stomach bloating and swelling 4%
  • Headache 4%
  • Uterine spasm 4%
  • Overstimulation of ovaries 7%
  • Nausea 8%
More Endometrin side effects »

The Aygestin FDA package insert doesn’t have numbers about how common side effects are.

More about Aygestin side effects »
How it works
EndometrinAygestin
Endometrin (progesterone vaginal insert) contains progesterone, an essential hormone for pregnancy. Progesterone prepares the uterus to receive and nourish a fertilized egg.Aygestin (norethindrone) contains norethindrone, a synthetic progesterone hormone. It regulates your period, treats irregular vaginal bleeding, and eases the pain of endometriosis (a condition where tissue that lines your uterus is found in other parts of the body).
Type of medication
EndometrinAygestin
Prescription onlyNo lower cost generic availablePrescription onlyLower-cost generic available
Available as
EndometrinAygestin
  • Vaginal insert
  • Pill
Used for
EndometrinAygestin
  • Pain Caused By Endometriosis
Risk factors for serious side effects
EndometrinAygestin
  • History of heart disease
  • History of blood clots
  • History of depression
Detailed Endometrin (progesterone vaginal insert) risks & warnings »
  • Personal or family history of blood clots
  • Smoking
  • Obesity
  • Systemic lupus erythematosus (SLE)
  • History of depression
Detailed Aygestin (norethindrone) risks & warnings »
Pregnancy

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Kidneys and liver
EndometrinAygestin
No kidneys and liver related info.
  • Aygestin (norethindrone) is broken down by the liver, so if the liver is damaged, the drug can build up in your body. Tell your doctor if you've had liver disease or damage. Your doctor will have to change Aygestin (norethindrone) to a different medicine.
Pain
EndometrinAygestin
No pain related info.
  • Aygestin (norethindrone) can raise your risk of blood clots, which can be very dangerous. You're more likely to have them if you smoke tobacco, are obese, or if you or your family have ever had blood clots. Get medical care right away if you have pain in your legs or arms, bad headaches, trouble breathing, or sudden changes in your speech or vision.
  • Tell your doctor about any severe stomach pain or yellowing of your eyes or skin.
Weight
EndometrinAygestin
No weight related info.
  • Aygestin (norethindrone) can cause cramps, bloating, trouble sleeping, acne, weight gain, or irregular periods.
  • Can make you gain weight.
Upsides and benefits
EndometrinAygestin
  • Helps increase your chances of getting pregnant.
  • Exposes your body to less hormone compared to progesterone pills or injections.
  • Endometrin (progesterone vaginal insert) replaces low levels of progesterone to prepare the lining of your uterus to receive and nourish a fertilized egg.
  • Endometrin (progesterone vaginal insert) comes with step-by-step instructions and is easy to use. Unlike some progesterone products that must be inserted lying down, Endometrin (progesterone vaginal insert) can be inserted while you are standing, sitting, or lying on your back with your knees bent.
  • Helps to regulate your period.
  • Decreases bleeding from hormone imbalance.
  • Available as a generic medication, so it costs less.
Downsides and risks
EndometrinAygestin
  • Endometrin (progesterone vaginal insert) can cause vaginal irritation and burning.
  • Inserting the applicator can possibly cause discomfort or infection.
  • Endometrin (progesterone vaginal insert) is dosed 2 to 3 times a day, compared to other progesterone products that are dosed 1 to 2 times a day.
  • You can't use tampons or other vaginal products for at least 6 hours before and 6 hours after using Endometrin (progesterone vaginal insert).
  • Only available as brand name, so it may be expensive.
  • Can make you gain weight.
  • Higher risk of blood clots.
  • Not for people who are post-menopausal, pregnant, or breast-feeding.
  • Can cause a lot of side effects.
Tips from our pharmacists for people taking the medication
EndometrinAygestin
  • Your doctor will give you specific directions on when and how long to use Endometrin (progesterone vaginal insert).
  • Always unwrap the applicator before using Endometrin (progesterone vaginal insert).
  • Endometrin (progesterone vaginal insert) can be inserted while you are standing, sitting, or lying on your back with your knees bent.
  • Each vaginal insert applicator is made for a single use and should be thrown away after you use it.
  • Don't use any other vaginal products when you are using Endometrin (progesterone vaginal insert).
  • Tell your doctor right away if you have any irregular menstrual bleeding after your start using Endometrin (progesterone vaginal insert).
  • The dose of Aygestin (norethindrone) will be different depending on what you’re using it for, so take it exactly the way your doctor tells you.
  • It's important to take it at the same time every day.
  • Talk to your doctor every few months about using the lowest possible dose of Aygestin (norethindrone). Since there can be a lot of long-term side effects, take it only as long as you need it.
  • If you're taking Aygestin (norethindrone) to regulate your period, you'll get withdrawal bleeding 3 to 7 days after stopping Aygestin (norethindrone).
  • Aygestin (norethindrone) can cause cramps, bloating, trouble sleeping, acne, weight gain, or irregular periods.
  • Tell your doctor about any severe stomach pain or yellowing of your eyes or skin.
Learn more
More about EndometrinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Endometrin (progesterone vaginal insert)?
Worth itNot sureNot worth it
More about AygestinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Aygestin (norethindrone)?
Worth itNot sureNot worth it