Compare Endometrin vs. Prometrium

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Endometrin
(progesterone vaginal insert)

Prometrium
(Progesterone)

Supports other fertility treatments. Endometrin (progesterone vaginal insert) is a vaginal insert used in fertility treatments, but you have to apply it more often than progesterone vaginal gel.Taken for irregular bleeding or paired with estrogen replacements for menopause. Prometrium (Progesterone) regulates menstrual cycles, treats heavy bleeding, and prevents thickening of the uterus.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
3.96Endometrin
Reviews for Endometrin
45%
of people (All ages) say Endometrin is worth it
20%
say it works well
27%
say it's a big hassle
Have you used Endometrin (progesterone vaginal insert)?
Worth itNot sureNot worth it
Reviews for Prometrium
61%
-16% worse vs. Endometrin
41%
-21% worse vs. Endometrin
17%
-10% worse vs. Endometrin
Have you used Prometrium (Progesterone)?
Worth itNot sureNot worth it
Side effects
EndometrinPrometrium
  • Constipation 2%
  • Fatigue 2%
  • Bladder infection 2%
  • Vomiting 3%
  • Vaginal bleeding 3%
  • Stomach bloating and swelling 4%
  • Headache 4%
  • Uterine spasm 4%
  • Overstimulation of ovaries 7%
  • Nausea 8%
More Endometrin side effects »
  • Breast Carcinoma 2%
  • Breast Excisional Biopsy 2%
  • Cholecystectomy 2%
  • Constipation 1%
  • Breast Pain 4%
  • Chest Pain 2%
  • Diarrhea 3%
More Prometrium side effects »
How it works
EndometrinPrometrium
Endometrin (progesterone vaginal insert) contains progesterone, an essential hormone for pregnancy. Progesterone prepares the uterus to receive and nourish a fertilized egg.Prometrium (Progesterone) contains progesterone, a hormone that regulates the menstrual cycle and protects the uterus from the negative effects of estrogen when used for postmenopausal treatment.
Type of medication
EndometrinPrometrium
Prescription onlyNo lower cost generic availablePrescription onlyLower-cost generic available
Available as
EndometrinPrometrium
  • Vaginal insert
  • Pill
  • Injection
Used for
EndometrinPrometrium
  • Amenorrhea
Risk factors for serious side effects
EndometrinPrometrium
  • History of heart disease
  • History of blood clots
  • History of depression
Detailed Endometrin (progesterone vaginal insert) risks & warnings »
  • Personal or family history of breast cancer
  • Family history of ovarian cancer
  • Personal or family history of blood clots
  • Smoking
  • Obesity
Detailed Prometrium (Progesterone) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Pain
EndometrinPrometrium
No pain related info.
  • Tell your doctor about any severe stomach pain or yellowing of your eyes or skin.
  • Relives pain from endometriosis.
Weight
EndometrinPrometrium
No weight related info.
  • Prometrium (Progesterone) contains progestin. It could cause a higher risk of ovarian cancer, especially if you have a family history of it. Your doctor can help you weigh the risks versus the benefits of this medication.
  • Can cause cramps, bloating, trouble sleeping, acne, weight gain, facial skin discoloration, or irregular periods.
Upsides and benefits
EndometrinPrometrium
  • Helps increase your chances of getting pregnant.
  • Exposes your body to less hormone compared to progesterone pills or injections.
  • Endometrin (progesterone vaginal insert) replaces low levels of progesterone to prepare the lining of your uterus to receive and nourish a fertilized egg.
  • Endometrin (progesterone vaginal insert) comes with step-by-step instructions and is easy to use. Unlike some progesterone products that must be inserted lying down, Endometrin (progesterone vaginal insert) can be inserted while you are standing, sitting, or lying on your back with your knees bent.
  • Helps to regulate your menstrual cycle.
  • Relives pain from endometriosis.
  • Lowers the risk of uterine cancer when used with estrogen in women with an intact uterus.
  • Available as a capsule or an injection, so you can choose what works best for you.
Downsides and risks
EndometrinPrometrium
  • Endometrin (progesterone vaginal insert) can cause vaginal irritation and burning.
  • Inserting the applicator can possibly cause discomfort or infection.
  • Endometrin (progesterone vaginal insert) is dosed 2 to 3 times a day, compared to other progesterone products that are dosed 1 to 2 times a day.
  • You can't use tampons or other vaginal products for at least 6 hours before and 6 hours after using Endometrin (progesterone vaginal insert).
  • Only available as brand name, so it may be expensive.
  • Prometrium (Progesterone) capsules contain peanut oil, so you can't take it if you're allergic to peanuts.
  • Prometrium (Progesterone) can cause serious birth defects in babies, so you can't take Prometrium (Progesterone) if you’re pregnant or breast-feeding.
  • Increases your risk of blood clots.
Tips from our pharmacists for people taking the medication
EndometrinPrometrium
  • Your doctor will give you specific directions on when and how long to use Endometrin (progesterone vaginal insert).
  • Always unwrap the applicator before using Endometrin (progesterone vaginal insert).
  • Endometrin (progesterone vaginal insert) can be inserted while you are standing, sitting, or lying on your back with your knees bent.
  • Each vaginal insert applicator is made for a single use and should be thrown away after you use it.
  • Don't use any other vaginal products when you are using Endometrin (progesterone vaginal insert).
  • Tell your doctor right away if you have any irregular menstrual bleeding after your start using Endometrin (progesterone vaginal insert).
  • The dose of Prometrium (Progesterone) will be different depending on what you’re using it for, so take it exactly the way your doctor tells you.
  • It's important to take it the same time every day.
  • Prometrium (Progesterone) capsules can make you feel tired or dizzy, so take it just before you go to sleep every night.
  • If you have trouble swallowing the capsule, take it with a full glass of water while standing up.
  • Can cause cramps, bloating, trouble sleeping, acne, weight gain, facial skin discoloration, or irregular periods.
  • Tell your doctor about any severe stomach pain or yellowing of your eyes or skin.
  • Get immediate medical help if you have sudden vision changes or one-sided weakness (signs of stroke) or chest pain and trouble breathing (signs of a pulmonary embolism).
Learn more
More about EndometrinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Endometrin (progesterone vaginal insert)?
Worth itNot sureNot worth it
More about PrometriumSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Prometrium (Progesterone)?
Worth itNot sureNot worth it