Compare Endometrin vs. Prometrium

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Endometrin
(Progesterone Vaginal Insert)

Prometrium
(Progesterone)

Supports fertility treatments. Endometrin (Progesterone Vaginal Insert) is a vaginal insert used in fertility treatments, but you have to apply it more often than progesterone vaginal gel.Taken for irregular bleeding or paired with estrogen replacements for menopause. Prometrium (Progesterone) regulates menstrual cycles, treats heavy bleeding, and prevents thickening of the uterus.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
3.963636363636364Endometrin
Reviews for Endometrin (Progesterone Vaginal Insert)
45%
of people say Endometrin (Progesterone Vaginal Insert) is worth it
20%
say it works well
27%
say it's a big hassle
Reviews for Prometrium (Progesterone)
62%
+17% vs. Endometrin (Progesterone Vaginal Insert)
41%
+21% vs. Endometrin (Progesterone Vaginal Insert)
16%
+11% vs. Endometrin (Progesterone Vaginal Insert)
Side effects
EndometrinPrometrium

The Endometrin FDA package insert doesn’t have numbers about how common side effects are.

More about Endometrin side effects »
  • Breast tenderness 21%
  • Dizziness 20%
  • Breast pain 8%
  • Musculoskeletal pain 8%
  • Low mood disorder 7%
  • Abdominal pain (cramping) 7%
  • Vaginal discharge 7%
  • Abdominal bloating 7%
  • Worry 4%
  • Irritability 4%
More Prometrium side effects »
How it works
EndometrinPrometrium
Endometrin (Progesterone Vaginal Insert) contains progesterone, one of the hormones essential for maintaining a pregnancy. Women on fertility treatment can take progesterone to prepare the lining of the uterus to receive and nourish a fertilized egg.Prometrium (Progesterone) contains progesterone, a hormone that regulates the menstrual cycle and protects the uterus from the negative effects of estrogen when used for postmenopausal treatment.
Type of medication
EndometrinPrometrium
ProgestinPrescription only
ProgestinPrescription only
Available as
EndometrinPrometrium
  • Vaginal insert
  • Pill
  • Injection
Used for (click to learn more)
EndometrinPrometrium
  • Female infertility
  • Amenorrhea
Risk factors for serious side effects
EndometrinPrometrium
  • Personal or family history of breast cancer
  • Family history of ovarian cancer
  • Personal or family history of blood clots
  • Smoking
  • Obesity
  • Hypertension
  • Diabetes
  • High cholesterol
  • Systemic lupus erythematosus (SLE)
  • Diabetes
  • Heart failure
  • Kidney problems
  • Obesity
Detailed Endometrin (Progesterone Vaginal Insert) risks & warnings »
  • Personal or family history of breast cancer
  • Family history of ovarian cancer
  • Personal or family history of blood clots
  • Smoking
  • Obesity
  • Hypertension
  • Diabetes
  • High cholesterol
  • Systemic lupus erythematosus (SLE)
  • Allergy to peanuts
  • Heart failure
  • Kidney problems
  • Obesity
  • History of depression
Detailed Prometrium (Progesterone) risks & warnings »
Pregnancy category
EndometrinPrometrium
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
BFDA pregnancy category (Probably safe)

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

See the FDA package insert
Alcohol
No specific alcohol-related info.No specific alcohol-related info.
Food
No specific food-related info.No specific food-related info.
Kidneys and liver
No specific kidneys and liver-related info.No specific kidneys and liver-related info.
Sex
No specific sex-related info.No specific sex-related info.
Sleep
No specific sleep-related info.
  • Prometrium (Progesterone) capsules can make you feel tired or dizzy, so take it just before you go to sleep every night.
  • Can cause cramps, bloating, trouble sleeping, acne, weight gain, facial skin discoloration, or irregular periods.
Weight
No specific weight-related info.
  • Can cause cramps, bloating, trouble sleeping, acne, weight gain, facial skin discoloration, or irregular periods.
Upsides and benefits
EndometrinPrometrium
  • Helps increase your chances of getting pregnant.
  • Regulates your menstrual cycle.
  • Exposes your body to less hormone compared to progesterone pills or injections.
  • Endometrin (Progesterone Vaginal Insert) replaces low levels of progesterone to prepare the lining of your uterus to receive and nourish a fertilized egg.
  • Endometrin (Progesterone Vaginal Insert) comes with step-by-step instructions and is easy to use. Unlike some progesterone products that make you to lie down when inserting them, Endometrin (Progesterone Vaginal Insert) can be inserted while you are standing, sitting, or lying on your back with your knees bent.
  • Helps to regulate your menstrual cycle.
  • Relives pain from endometriosis.
  • Lowers the risk of uterine cancer when used with estrogen in women with an intact uterus.
  • Available as a capsule or an injection, so you can choose what works best for you.
Downsides and risks
EndometrinPrometrium
  • Endometrin (Progesterone Vaginal Insert) can cause vaginal irritation and burning.
  • Inserting the applicator can possibly cause discomfort or infection.
  • Endometrin (Progesterone Vaginal Insert) is dosed 2 to 3 times a day, compared to other progesterone products that are dosed 1 to 2 times a day.
  • You can't use tampons or other vaginal products for at least 6 hours before and 6 hours after taking Endometrin (Progesterone Vaginal Insert).
  • Prometrium (Progesterone) capsules contain peanut oil, so you can't take it if you're allergic to peanuts.
  • Prometrium (Progesterone) can cause serious birth defects in babies, so you can't take Prometrium (Progesterone) if you’re pregnant or breast-feeding.
  • Increases your risk of blood clots.
Tips from our pharmacists for people taking the medication
EndometrinPrometrium
  • Read the information you get in the pharmacy about how to use Endometrin (Progesterone Vaginal Insert). The step-by-step instructions are really helpful to follow.
  • Each vaginal insert applicator is made for a single use and should be thrown away after you use it.
  • The dose of Prometrium (Progesterone) will be different depending on what you’re using it for, so take it exactly the way your doctor tells you.
  • It's important to take it the same time every day.
  • Prometrium (Progesterone) capsules can make you feel tired or dizzy, so take it just before you go to sleep every night.
  • If you have trouble swallowing the capsule, take it with a full glass of water while standing up.
  • Can cause cramps, bloating, trouble sleeping, acne, weight gain, facial skin discoloration, or irregular periods.
  • Tell your doctor about any severe stomach pain or yellowing of your eyes or skin.
  • Get immediate medical help if you have sudden vision changes or one-sided weakness (signs of stroke) or chest pain and trouble breathing (signs of a pulmonary embolism).
Learn more
More about EndometrinSide effectsReviews & ratingsAlternativesFDA package insert
More about PrometriumSide effectsReviews & ratingsAlternativesFDA package insert