Compare Endometrin vs. Provera

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Endometrin
(progesterone vaginal insert)

Provera
(medroxyprogesterone)

Supports other fertility treatments. Endometrin (progesterone vaginal insert) is a vaginal insert used in fertility treatments, but you have to apply it more often than progesterone vaginal gel.Regulates your menstrual cycle and supplements estrogen treatments for menopause. Provera (Medroxyprogesterone) works well to regulate your menstrual cycle and stop irregular bleeding. It also protects the uterus from estrogen's harmful effects.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
3.96Endometrin
Reviews for Endometrin
45%
of people (All ages) say Endometrin is worth it
20%
say it works well
27%
say it's a big hassle
Have you used Endometrin (progesterone vaginal insert)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Provera (medroxyprogesterone)?
Worth itNot sureNot worth it
Side effects
EndometrinProvera
  • Pain after egg harvesting 28%
  • Stomach pain 12%
  • Nausea 8%
  • Overstimulation of ovaries 7%
  • Stomach bloating and swelling 4%
  • Uterine spasm 4%
  • Headache 4%
  • Vaginal bleeding 3%
  • Vomiting 3%
  • Fatigue 2%
More Endometrin side effects »

We haven’t found good data for Provera side effects.

FDA side effect reports for Provera »
How it works
EndometrinProvera
Endometrin (progesterone vaginal insert) contains progesterone, an essential hormone for pregnancy. Progesterone prepares the uterus to receive and nourish a fertilized egg.Provera (Medroxyprogesterone) contains medroxyprogesterone, a progesterone hormone that works to balance hormone changes in the body. In premenopausal women, it prevents thickening of the uterus lining and regulates your menstrual cycle. It's also added to hormone therapy to protect the uterus from the harmful effects of estrogen.
Type of medication
EndometrinProvera
Prescription onlyPrescription only
Available as
EndometrinProvera
  • Vaginal insert
  • Pill
Used for
EndometrinProvera
  • Amenorrhea
Risk factors for serious side effects
EndometrinProvera
  • History of heart disease
  • History of blood clots
  • History of depression
Detailed Endometrin (progesterone vaginal insert) risks & warnings »
  • Personal or family history of breast cancer
  • Family history of ovarian cancer
  • Personal or family history of blood clots
  • Smoking
  • Obesity
Detailed Provera (medroxyprogesterone) risks & warnings »
Pregnancy

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Weight
EndometrinProvera
No weight related info.
  • Provera (Medroxyprogesterone) contains progestin. It could cause a higher risk of ovarian cancer, especially if you have a family history of it. Your doctor can help you weigh the risks versus the benefits of this medication.
  • Can cause headache, weight gain, breast tenderness, or changes in mood.
Upsides and benefits
EndometrinProvera
  • Helps increase your chances of getting pregnant.
  • Exposes your body to less hormone compared to progesterone pills or injections.
  • Endometrin (progesterone vaginal insert) replaces low levels of progesterone to prepare the lining of your uterus to receive and nourish a fertilized egg.
  • Endometrin (progesterone vaginal insert) comes with step-by-step instructions and is easy to use. Unlike some progesterone products that must be inserted lying down, Endometrin (progesterone vaginal insert) can be inserted while you are standing, sitting, or lying on your back with your knees bent.
  • Provera (Medroxyprogesterone) can be used to treat multiple hormone problems in women.
  • After menopause, taking estrogen raises your risk of uterine cancer. However, taking progesterone, like in Provera (Medroxyprogesterone), along with estrogen gives you the positive effects of estrogen, but also prevents it from damaging your uterus.
  • Women taking an estrogen/progestin combination medications have a lower risk of uterine cancer.
Downsides and risks
EndometrinProvera
  • Endometrin (progesterone vaginal insert) can cause vaginal irritation and burning.
  • Inserting the applicator can possibly cause discomfort or infection.
  • Endometrin (progesterone vaginal insert) is dosed 2 to 3 times a day, compared to other progesterone products that are dosed 1 to 2 times a day.
  • You can't use tampons or other vaginal products for at least 6 hours before and 6 hours after using Endometrin (progesterone vaginal insert).
  • Only available as brand name, so it may be expensive.
  • You can't take Provera (Medroxyprogesterone) if you've had a hysterectomy (your uterus removed). You also can't take it if you're pregnant or breastfeeding, have unusual vaginal bleeding, or have a history of blood clots, certain kinds of cancer, stroke, heart attack, liver problems, or bleeding problems.
Tips from our pharmacists for people taking the medication
EndometrinProvera
  • Your doctor will give you specific directions on when and how long to use Endometrin (progesterone vaginal insert).
  • Always unwrap the applicator before using Endometrin (progesterone vaginal insert).
  • Endometrin (progesterone vaginal insert) can be inserted while you are standing, sitting, or lying on your back with your knees bent.
  • Each vaginal insert applicator is made for a single use and should be thrown away after you use it.
  • Don't use any other vaginal products when you are using Endometrin (progesterone vaginal insert).
  • Tell your doctor right away if you have any irregular menstrual bleeding after your start using Endometrin (progesterone vaginal insert).
  • The dose of Provera (Medroxyprogesterone) will be different depending on what you’re using it for, so take it exactly the way your doctor tells you.
  • Talk to your doctor every few months about using the lowest possible dose of Provera (Medroxyprogesterone). Since there can be a lot of long-term side effects, take it only as long as you need it.
  • Can cause headache, weight gain, breast tenderness, or changes in mood.
  • If you're taking Provera (Medroxyprogesterone) to regulate your period, you'll get withdrawal bleeding 3 to 7 days after stopping Provera (Medroxyprogesterone).
Learn more
More about EndometrinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Endometrin (progesterone vaginal insert)?
Worth itNot sureNot worth it
More about ProveraSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Provera (medroxyprogesterone)?
Worth itNot sureNot worth it