Compare entacapone vs. Apokyn

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Comtan
(entacapone)

Apokyn
(apomorphine)

Treats Parkinson's disease. Comtan (entacapone) enhances the effect of carbidopa/levodopa. It's usually added on when carbidopa/levodopa starts to lose its effect on Parkinson's disease.Helps you move around. Apokyn (apomorphine) is good for treating the "off" episodes or difficulty moving around when you have advanced Parkinson's disease, but it can cause vomiting and sudden sleepiness.
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Prices and coupon for 90 (200mg) tablets of entacapone
Coupons for
Prices and coupon for 20 (3ml of 30mg/3ml) cartridges of apomorphine
Reviews & ratings
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Have you used Comtan (entacapone)?
Worth itNot sureNot worth it

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Have you used Apokyn (apomorphine)?
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Side effects
entacaponeApokyn
  • Difficulty controlling movements 10%
  • Nausea 6%
  • Muscle spasm 5%
  • Changes in urine color 10%
  • Diarrhea 6%
  • Muscle rigidity 1%
  • Dizziness 2%
  • Abdominal pain 4%
  • Fatigue 2%
  • Constipation 2%
More entacapone side effects »
  • Yawning 40%
  • Movement problems 24%
  • Drowsiness or sleepiness 35%
  • Nausea or vomiting 19%
  • Dizziness 20%
  • Runny nose 20%
  • Chest pain 15%
  • Hallucinations 10%
  • Swelling in arms and legs 10%
More Apokyn side effects »
How it works
entacaponeApokyn
Comtan (entacapone) is a COMT inhibitor. It prevents levodopa from breaking down before it enters the brain.Apokyn (apomorphine) is a non-ergoline dopamine agonist. Apokyn (apomorphine) allows you to move around more freely by stimulating the brain's ability to use dopamine, which is important for movement.
Type of medication
entacaponeApokyn
Prescription only
Prescription only
Available as
entacaponeApokyn
  • Pill
  • Injection
Used for
entacaponeApokyn
Risk factors for serious side effects
entacaponeApokyn
  • Taking other medicines for Parkinson's
    • Low blood pressure
    • Taking medicines for high blood pressure
    • Taking other medicines for Parkinson's disease
        Detailed Comtan (entacapone) risks & warnings »
          • Taking antipsychotic medicines
          • Taking other medicines for Parkinson's disease
          • History of heart disease or stroke
              Detailed Apokyn (apomorphine) risks & warnings »
              Pregnancy

              Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              Sleep
              entacaponeApokyn
              • Can make you very sleepy
              • Can make you very sleepy. Don't drive or do anything requiring concentration until you know how it affects you.
              • Comtan (entacapone) can make you very sleepy. Don't drive or do anything that requires your full concentration until you know how Comtan (entacapone) affects you. This is more likely if you're also taking other medicines for Parkinson's. Talk to your doctor if this bothers you.
              • Apokyn (apomorphine) can make you sleepy or fall asleep without warning. Don't drive or do anything that requires concentration until you know how it affects you.
              • Apokyn (apomorphine) can make you sleepy or fall asleep suddenly without warning. Don't drive or do anything that requires your full concentration until you know how Apokyn (apomorphine) affects you. You're more at risk if you're taking other medicines for Parkinson's. Talk to your doctor if this bothers you.
              Upsides and benefits
              entacaponeApokyn
              • Allows you to get more out of carbidopa/levodopa, especially in later stages of Parkinson's disease.
              • Comtan (entacapone) is available in a single pill combination with carbidopa/levodopa.
              • Preferred drug according to the guidelines to treat the "off" periods or inability to control movements well that's associated with Parkinson's.
              • People respond to the injection of Apokyn (apomorphine) very quickly and this response can last longer than other medicines.
              Downsides and risks
              entacaponeApokyn
              • Must be taken with other medicines for Parkinson's disease
              • Can make you lightheaded especially if you suddenly stand up from sitting or lying down.
              • Can make you very sleepy
              • May require frequent adjustments before finding the dose that works best for you
              • Can cause vomiting and sudden sleepiness. Your doctor will have to give you a medicine to stop the vomiting from happening.
              • Apokyn (apomorphine) should only be used if you have an "off" period of moving around. You should keep using your other medicines for your Parkinson's.
              • Dosing can be confusing since the pen only dispenses in milliliters, and there have been reports of people getting overdoses of Apokyn (apomorphine) because they thought it was for milligrams.
              • Stopping Apokyn (apomorphine) suddenly or lowering the dose too quickly can cause your muscles to become very stiff and you might get a very high fever, which can be life threatening. Talk to your doctor if you want to stop taking this medicine.
              Tips from our pharmacists for people taking the medication
              entacaponeApokyn
              • Doesn't work by itself. Must be taken with other medicines for Parkinson's disease
              • Can make you lightheaded especially if you suddenly stand up from sitting or lying down.
              • Can make you very sleepy. Don't drive or do anything requiring concentration until you know how it affects you.
              • May cause an upset stomach
              • May require frequent adjusting until you the dose that works best
              • Apokyn (apomorphine) can cause nausea, so your doctor will give you medicine to help stop that and vomiting.
              • Your doctor will tell you how much Apokyn (apomorphine) you will inject. This is given in milliliters. Turn the pen so that the correct dose is given.
              • Apokyn (apomorphine) can make you sleepy or fall asleep without warning. Don't drive or do anything that requires concentration until you know how it affects you.
              • Always change where you inject Apokyn (apomorphine) and always use a fresh needle every time. This will make injecting safer and less painful.
              • If the liquid inside the Apokyn (apomorphine) cartridge does not look clear and colorless, don't use it. Use a new cartridge or call your pharmacy.
              • Can cause you to feel faint, especially if you get up after sitting or lying down for a while. Be careful moving around after you use Apokyn (apomorphine) so you don't fall.
              Learn more
              More about entacaponeSide effectsAlternativesFDA package insert
              Have you used Comtan (entacapone)?
              Worth itNot sureNot worth it
              More about ApokynSide effectsAlternativesFDA package insert
              Have you used Apokyn (apomorphine)?
              Worth itNot sureNot worth it