Compare entacapone vs. Azilect

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Comtan
(entacapone)

Azilect
(rasagiline)

Treats Parkinson's disease. Comtan (entacapone) enhances the effect of carbidopa/levodopa. It's usually added on when carbidopa/levodopa starts to lose its effect on Parkinson's disease.Treats Parkinson's disease. Azilect (rasagiline) is one of the recommended medicines to treat Parkinson's disease. It is now available in generic, which makes it more affordable for people without insurance.
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Coupons for entacapone
Best available price for 90 (200mg) tablets of entacapone
Coupons for Azilect
Best available price for 30 (1mg) tablets of rasagiline
Reviews & ratings
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Reviews for Comtan (entacapone)
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of people (All ages) say Comtan (entacapone) is worth it
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say it works well
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say it's a big hassle
Have you used Comtan (entacapone)?
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Reviews for Azilect (rasagiline)
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Same vs. Comtan (entacapone)
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Same vs. Comtan (entacapone)
Have you used Azilect (rasagiline)?
Worth itNot sureNot worth it
Side effects
entacaponeAzilect
  • Difficulty controlling movements 10%
  • Nausea 6%
  • Muscle spasm 5%
  • Changes in urine color 10%
  • Diarrhea 6%
  • Muscle rigidity 1%
  • Dizziness 2%
  • Abdominal pain 4%
  • Fatigue 2%
  • Constipation 2%
More entacapone side effects »
  • Difficulty controlling movement 8%
  • Headache 2%
  • Accidental injury 7%
  • Nausea 4%
  • Falls 3%
  • Low blood pressure 6%
  • Constipation 4%
  • Weight loss 6%
  • Joint pain 4%
  • Diarrhea 3%
More Azilect side effects »
How it works
entacaponeAzilect
Comtan (entacapone) is a COMT inhibitor. It prevents levodopa from breaking down before it enters the brain.Azilect (rasagiline) is a monoamine oxidase inhibitor. It increases the amount of dopamine in the brain, which helps those with Parkinson's disease gain better control their movements.
Type of medication
entacaponeAzilect
Prescription only
Prescription only
Available as
entacaponeAzilect
  • Pill
  • Pill
Used for
entacaponeAzilect
Risk factors for serious side effects
entacaponeAzilect
  • Taking other medicines for Parkinson's
  • Low blood pressure
  • Taking medicines for high blood pressure
  • Taking other medicines for Parkinson's disease
Detailed Comtan (entacapone) risks & warnings »
  • Eating foods rich in tyramine, like soy sauce, fermented cheese and smoked meats
  • Tricyclic antidepressants
  • Fentanyl
  • Tramadol
  • Buspirone
Detailed Azilect (rasagiline) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Sleep
entacaponeAzilect
  • Can make you very sleepy
  • Can make you very sleepy. Don't drive or do anything requiring concentration until you know how it affects you.
  • Comtan (entacapone) can make you very sleepy. Don't drive or do anything that requires your full concentration until you know how Comtan (entacapone) affects you. This is more likely if you're also taking other medicines for Parkinson's. Talk to your doctor if this bothers you.
No sleep related info.
Upsides and benefits
entacaponeAzilect
  • Allows you to get more out of carbidopa/levodopa, especially in later stages of Parkinson's disease.
  • Comtan (entacapone) is available in a single pill combination with carbidopa/levodopa.
  • Azilect (rasagiline) is one of the go-to medicines for Parkinson's disease. It can be used in early and late stages of the disease.
  • Taking Azilect (rasagiline) by itself can help slow down Parkinson's disease, but it works better when it's given with other medicines.
  • Azilect (rasagiline) is available as generic as well as brand name, so there are usually lower out-of-pocket costs for you with insurance.
Downsides and risks
entacaponeAzilect
  • Must be taken with other medicines for Parkinson's disease
  • Can make you lightheaded especially if you suddenly stand up from sitting or lying down.
  • Can make you very sleepy
  • May require frequent adjustments before finding the dose that works best for you
  • It can cause unusual cravings and changes in behavior in some people.
Tips from our pharmacists for people taking the medication
entacaponeAzilect
  • Doesn't work by itself. Must be taken with other medicines for Parkinson's disease
  • Can make you lightheaded especially if you suddenly stand up from sitting or lying down.
  • Can make you very sleepy. Don't drive or do anything requiring concentration until you know how it affects you.
  • May cause an upset stomach
  • May require frequent adjusting until you the dose that works best
  • Azilect (rasagiline) can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
  • Watch how much cheese, soy sauce or smoked meats you eat. Eating too much of these foods while on Azilect (rasagiline) can cause an unsafe rise in blood pressure.
  • Azilect (rasagiline) can make you dizzy or lightheaded, especially when you suddenly stand up from sitting or laying down.
  • Don't stop taking Azilect (rasagiline) without talking to your doctor first. Stopping it suddenly can cause confusion, stiff muscles and a high fever.
  • Azilect (rasagiline) can prevent many medicines from working properly. Check with your doctor or pharmacist if the way you take your other medicines needs to be changed.
Learn more
More about entacaponeSide effectsAlternativesFDA package insert
Have you used Comtan (entacapone)?
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More about AzilectSide effectsAlternativesFDA package insert
Have you used Azilect (rasagiline)?
Worth itNot sureNot worth it