Compare entacapone vs. carbidopa

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Comtan
(entacapone)

Lodosyn
(carbidopa)

Treats Parkinson's disease. Comtan (entacapone) enhances the effect of carbidopa/levodopa. It's usually added on when carbidopa/levodopa starts to lose its effect on Parkinson's disease.Treats Parkinson's disease when given with levodopa. Lodosyn (carbidopa) enhances the effect of levodopa. It cannot relieve symptoms of Parkinson's disease when taken by itself.
Reviews & ratings
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Have you used Comtan (entacapone)?
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Have you used Lodosyn (carbidopa)?
Worth itNot sureNot worth it
Side effects
entacaponecarbidopa
  • Difficulty controlling movements 10%
  • Nausea 6%
  • Muscle spasm 5%
  • Changes in urine color 10%
  • Diarrhea 6%
  • Muscle rigidity 1%
  • Dizziness 2%
  • Abdominal pain 4%
  • Fatigue 2%
  • Constipation 2%
More entacapone side effects »

We haven’t found good data for carbidopa side effects.

FDA side effect reports for carbidopa »
How it works
entacaponecarbidopa
Comtan (entacapone) is a COMT inhibitor. It prevents levodopa from breaking down before it enters the brain.Lodosyn (carbidopa) is a decarboxylase inhibitor that allows levodopa to enter the brain and relieve symptoms of Parkinson's disease.
Type of medication
entacaponecarbidopa
Prescription onlyPrescription only
Available as
entacaponecarbidopa
  • Pill
  • Pill
Used for
entacaponecarbidopa
Risk factors for serious side effects
entacaponecarbidopa
  • Taking other medicines for Parkinson's
  • Low blood pressure
  • Taking medicines for high blood pressure
  • Taking other medicines for Parkinson's disease
Detailed Comtan (entacapone) risks & warnings »
    Detailed Lodosyn (carbidopa) risks & warnings »
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Sleep
    entacaponecarbidopa
    • Comtan (entacapone) can make you very sleepy. Don't drive or do anything that requires your full concentration until you know how Comtan (entacapone) affects you. This is more likely if you're also taking other medicines for Parkinson's. Talk to your doctor if this bothers you.
    • Can make you very sleepy. Don't drive or do anything requiring concentration until you know how it affects you.
    • Can make you very sleepy
    No sleep related info.
    Upsides and benefits
    entacaponecarbidopa
    • Allows you to get more out of carbidopa/levodopa, especially in later stages of Parkinson's disease.
    • Comtan (entacapone) is available in a single pill combination with carbidopa/levodopa.
    • Extra doses of Lodosyn (carbidopa) allows you to get more out of levodopa, especially in later stages of the disease.
    • It is available in a combination pill with levodopa once you find the right dose that works for you.
    Downsides and risks
    entacaponecarbidopa
    • Must be taken with other medicines for Parkinson's disease
    • Can make you lightheaded especially if you suddenly stand up from sitting or lying down.
    • Can make you very sleepy
    • May require frequent adjustments before finding the dose that works best for you
    • Your doctor may need to change the dose of Lodosyn (carbidopa) frequently before finding the right dose.
    Tips from our pharmacists for people taking the medication
    entacaponecarbidopa
    • Doesn't work by itself. Must be taken with other medicines for Parkinson's disease
    • Can make you lightheaded especially if you suddenly stand up from sitting or lying down.
    • Can make you very sleepy. Don't drive or do anything requiring concentration until you know how it affects you.
    • May cause an upset stomach
    • May require frequent adjusting until you the dose that works best
    • Lodosyn (carbidopa) can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
    • Your saliva, sweat and urine may have dark color and stain your clothing while taking Lodosyn (carbidopa).
    • Take Lodosyn (carbidopa) 30-60 minutes before a meal so that your body can properly absorb it. Don't eat too much high protein foods (meat, milk, cheese or nuts) because doing so can prevent it from getting absorbed into your body.
    • Lodosyn (carbidopa) doesn't work when taken by itself. Don't stop taking your other medicines for Parkinson's disease.
    • Lodosyn (carbidopa) may cause unusual cravings in some people.
    Learn more
    More about entacaponeSide effectsAlternativesFDA package insert
    Have you used Comtan (entacapone)?
    Worth itNot sureNot worth it
    More about carbidopaSide effectsAlternativesFDA package insert
    Have you used Lodosyn (carbidopa)?
    Worth itNot sureNot worth it