Compare entacapone vs. carbidopa/levodopa/entacapone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Comtan
(entacapone)

Stalevo
(carbidopa / levodopa / entacapone)

Treats Parkinson's disease. Comtan (entacapone) enhances the effect of carbidopa/levodopa. It's usually added on when carbidopa/levodopa starts to lose its effect on Parkinson's disease.Treats Parkinson's disease. Stalevo (carbidopa / levodopa / entacapone) is a good choice for Parkinson's disease, especially when carbidopa/levodopa starts losing its effect.
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Reviews & ratings
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Have you used Comtan (entacapone)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Stalevo (carbidopa / levodopa / entacapone)?
Worth itNot sureNot worth it
Side effects
entacaponecarbidopa/levodopa/entacapone
  • Difficulty controlling movements 10%
  • Nausea 6%
  • Muscle spasm 5%
  • Changes in urine color 10%
  • Diarrhea 6%
  • Muscle rigidity 1%
  • Dizziness 2%
  • Abdominal pain 4%
  • Fatigue 2%
  • Constipation 2%
More entacapone side effects »
  • Difficulty controlling movements 10%
  • Muscle spasm 5%
  • Changes in urine color 10%
  • Discolored urine 10%
  • Muscle rigidity 1%
  • Abdominal pain 4%
  • Dizziness 2%
  • Fatigue 2%
  • Constipation 2%
More carbidopa/levodopa/entacapone side effects »
How it works
entacaponecarbidopa/levodopa/entacapone
Comtan (entacapone) is a COMT inhibitor. It prevents levodopa from breaking down before it enters the brain.Stalevo (carbidopa / levodopa / entacapone) is a combination of carbidopa, levodopa, and entacapone. Entacopone and carbidopa prevent breakdown of levodopa in the body so that levodopa can then enter the brain and relieve symptoms of Parkinson's disease.
Type of medication
entacaponecarbidopa/levodopa/entacapone
Prescription only
Prescription only
Available as
entacaponecarbidopa/levodopa/entacapone
  • Pill
  • Pill
Used for
entacaponecarbidopa/levodopa/entacapone
Risk factors for serious side effects
entacaponecarbidopa/levodopa/entacapone
  • Taking other medicines for Parkinson's
    • Low blood pressure
    • Taking medicines for high blood pressure
    • Taking other medicines for Parkinson's disease
        Detailed Comtan (entacapone) risks & warnings »
                • History of stomach ulcers
                Detailed Stalevo (carbidopa / levodopa / entacapone) risks & warnings »
                Pregnancy

                Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                Sleep
                entacaponecarbidopa/levodopa/entacapone
                • Can make you very sleepy
                • Can make you very sleepy. Don't drive or do anything requiring concentration until you know how it affects you.
                • Comtan (entacapone) can make you very sleepy. Don't drive or do anything that requires your full concentration until you know how Comtan (entacapone) affects you. This is more likely if you're also taking other medicines for Parkinson's. Talk to your doctor if this bothers you.
                No sleep related info.
                Upsides and benefits
                entacaponecarbidopa/levodopa/entacapone
                • Allows you to get more out of carbidopa/levodopa, especially in later stages of Parkinson's disease.
                • Comtan (entacapone) is available in a single pill combination with carbidopa/levodopa.
                • It combines three medicines into one pill so you don't have to take so many pills daily.
                • Stalevo (carbidopa / levodopa / entacapone) is available as a generic.
                Downsides and risks
                entacaponecarbidopa/levodopa/entacapone
                • Must be taken with other medicines for Parkinson's disease
                • Can make you lightheaded especially if you suddenly stand up from sitting or lying down.
                • Can make you very sleepy
                • May require frequent adjustments before finding the dose that works best for you
                • You would first start by taking Stalevo (carbidopa / levodopa / entacapone) as two different pills, carbidopa/levodopa and entacapone, before you get switched over to Stalevo (carbidopa / levodopa / entacapone).
                • It's less customizable since there are only a few fixed combinations available.
                Tips from our pharmacists for people taking the medication
                entacaponecarbidopa/levodopa/entacapone
                • Doesn't work by itself. Must be taken with other medicines for Parkinson's disease
                • Can make you lightheaded especially if you suddenly stand up from sitting or lying down.
                • Can make you very sleepy. Don't drive or do anything requiring concentration until you know how it affects you.
                • May cause an upset stomach
                • May require frequent adjusting until you the dose that works best
                • Stalevo (carbidopa / levodopa / entacapone) can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
                • Your saliva, sweat and urine may have dark color and stain your clothing while taking Stalevo (carbidopa / levodopa / entacapone).
                • Take Stalevo (carbidopa / levodopa / entacapone) 30-60 minutes before a meal so that your body can properly absorb it. Don't eat too much high protein foods (meat, milk, cheese or nuts) because doing so can prevent it from getting absorbed into your body.
                • Stalevo (carbidopa / levodopa / entacapone) may cause unusual cravings in some people.
                Learn more
                More about entacaponeSide effectsAlternativesFDA package insert
                Have you used Comtan (entacapone)?
                Worth itNot sureNot worth it
                More about carbidopa/levodopa/entacaponeSide effectsAlternativesFDA package insert
                Have you used Stalevo (carbidopa / levodopa / entacapone)?
                Worth itNot sureNot worth it