Compare entacapone vs. carbidopa / levodopa / entacapone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

entacapone

carbidopa / levodopa / entacapone

Treats Parkinson's disease. Comtan (entacapone) enhances the effect of carbidopa/levodopa. It's usually added on when carbidopa/levodopa starts to lose its effect on Parkinson's disease.Treats Parkinson's disease. Stalevo (carbidopa / levodopa / entacapone) is a good choice for Parkinson's disease, especially when carbidopa/levodopa starts losing its effect.
Reviews & ratings
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Have you used Comtan (entacapone)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Stalevo (carbidopa / levodopa / entacapone)?
Worth itNot sureNot worth it
Side effects
entacaponecarbidopa / levodopa / entacapone
  • Increased sweating 1%
  • Back pain 1%
  • Anxiety 1%
  • Sleepiness 2%
  • Indigestion 1%
  • Flatulence 2%
  • Weakness 1%
  • Dry mouth 3%
  • Shortness of breath 2%
  • Purple spots on the skin 2%
More entacapone side effects »
  • Increased sweating 1%
  • Anxiety 1%
  • Sleepiness 2%
  • Indigestion 1%
  • Flatulence 2%
  • Weakness 1%
  • Dry mouth 3%
  • Shortness of breath 2%
  • Bruising 2%
  • Vomiting 3%
More carbidopa / levodopa / entacapone side effects »
How it works
entacaponecarbidopa / levodopa / entacapone
Comtan (entacapone) is a COMT inhibitor. It prevents levodopa from breaking down before it enters the brain.Stalevo (carbidopa / levodopa / entacapone) is a combination of carbidopa, levodopa, and entacapone. Entacopone and carbidopa prevent breakdown of levodopa in the body so that levodopa can then enter the brain and relieve symptoms of Parkinson's disease.
Type of medication
entacaponecarbidopa / levodopa / entacapone
Prescription onlyLower-cost generic availablePrescription onlyLower-cost generic available
Available as
entacaponecarbidopa / levodopa / entacapone
  • Pill
  • Pill
Used for
entacaponecarbidopa / levodopa / entacapone
Risk factors for serious side effects
entacaponecarbidopa / levodopa / entacapone
  • Taking other medicines for Parkinson's
  • Low blood pressure
  • Taking medicines for high blood pressure
  • Taking other medicines for Parkinson's disease
Detailed Comtan (entacapone) risks & warnings »
  • History of stomach ulcers
Detailed Stalevo (carbidopa / levodopa / entacapone) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Sleep
entacaponecarbidopa / levodopa / entacapone
  • Comtan (entacapone) can make you very sleepy. Don't drive or do anything that requires your full concentration until you know how Comtan (entacapone) affects you. This is more likely if you're also taking other medicines for Parkinson's. Talk to your doctor if this bothers you.
  • Can make you very sleepy. Don't drive or do anything requiring concentration until you know how it affects you.
  • Can make you very sleepy
No sleep related info.
Upsides and benefits
entacaponecarbidopa / levodopa / entacapone
  • Allows you to get more out of carbidopa/levodopa, especially in later stages of Parkinson's disease.
  • Comtan (entacapone) is available in a single pill combination with carbidopa/levodopa.
  • It combines three medicines into one pill so you don't have to take so many pills daily.
  • Stalevo (carbidopa / levodopa / entacapone) is available as a generic.
Downsides and risks
entacaponecarbidopa / levodopa / entacapone
  • Must be taken with other medicines for Parkinson's disease
  • Can make you lightheaded especially if you suddenly stand up from sitting or lying down.
  • Can make you very sleepy
  • May require frequent adjustments before finding the dose that works best for you
  • You would first start by taking Stalevo (carbidopa / levodopa / entacapone) as two different pills, carbidopa/levodopa and entacapone, before you get switched over to Stalevo (carbidopa / levodopa / entacapone).
  • It's less customizable since there are only a few fixed combinations available.
Tips from our pharmacists for people taking the medication
entacaponecarbidopa / levodopa / entacapone
  • Doesn't work by itself. Must be taken with other medicines for Parkinson's disease
  • Can make you lightheaded especially if you suddenly stand up from sitting or lying down.
  • Can make you very sleepy. Don't drive or do anything requiring concentration until you know how it affects you.
  • May cause an upset stomach
  • May require frequent adjusting until you the dose that works best
  • Stalevo (carbidopa / levodopa / entacapone) can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
  • Your saliva, sweat and urine may have dark color and stain your clothing while taking Stalevo (carbidopa / levodopa / entacapone).
  • Take Stalevo (carbidopa / levodopa / entacapone) 30-60 minutes before a meal so that your body can properly absorb it. Don't eat too much high protein foods (meat, milk, cheese or nuts) because doing so can prevent it from getting absorbed into your body.
  • Stalevo (carbidopa / levodopa / entacapone) may cause unusual cravings in some people.
Learn more
More about entacaponeSide effectsAlternativesFDA package insert
Have you used Comtan (entacapone)?
Worth itNot sureNot worth it
More about carbidopa / levodopa / entacaponeSide effectsAlternativesFDA package insert
Have you used Stalevo (carbidopa / levodopa / entacapone)?
Worth itNot sureNot worth it