Compare entacapone vs. carbidopa / levodopa / entacapone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Comtan
(entacapone)

Stalevo
(carbidopa / levodopa / entacapone)

Treats Parkinson's disease. Comtan (entacapone) enhances the effect of carbidopa/levodopa. It's usually added on when carbidopa/levodopa starts to lose its effect on Parkinson's disease.Treats Parkinson's disease. Stalevo (carbidopa / levodopa / entacapone) is a good choice for Parkinson's disease, especially when carbidopa/levodopa starts losing its effect.
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Best available price for 90 (200mg) tablets of entacapone
Best available price for 120 (150mg) tablets of carbidopa / levodopa / entacapone
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
Reviews for Comtan (entacapone)
Not enough review data. Review it!
of people (All ages) say Comtan (entacapone) is worth it
Not enough review data. Review it!
say it works well
Not enough review data. Review it!
say it's a big hassle
Have you used Comtan (entacapone)?
Worth itNot sureNot worth it
Reviews for Stalevo (carbidopa / levodopa / entacapone)
Not enough review data. Review it!
Same vs. Comtan (entacapone)
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Same vs. Comtan (entacapone)
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Same vs. Comtan (entacapone)
Have you used Stalevo (carbidopa / levodopa / entacapone)?
Worth itNot sureNot worth it
Side effects
entacaponecarbidopa / levodopa / entacapone
  • Difficulty controlling movements 10%
  • Nausea 6%
  • Muscle spasm 5%
  • Changes in urine color 10%
  • Diarrhea 6%
  • Muscle rigidity 1%
  • Dizziness 2%
  • Abdominal pain 4%
  • Fatigue 2%
  • Constipation 2%
More entacapone side effects »
  • Difficulty controlling movements 10%
  • Muscle spasm 5%
  • Changes in urine color 10%
  • Discolored urine 10%
  • Muscle rigidity 1%
  • Abdominal pain 4%
  • Dizziness 2%
  • Fatigue 2%
  • Constipation 2%
More carbidopa / levodopa / entacapone side effects »
How it works
entacaponecarbidopa / levodopa / entacapone
Comtan (entacapone) is a COMT inhibitor. It prevents levodopa from breaking down before it enters the brain.Stalevo (carbidopa / levodopa / entacapone) is a combination of carbidopa, levodopa, and entacapone. Entacopone and carbidopa prevent breakdown of levodopa in the body so that levodopa can then enter the brain and relieve symptoms of Parkinson's disease.
Type of medication
entacaponecarbidopa / levodopa / entacapone
Prescription only
Prescription only
Available as
entacaponecarbidopa / levodopa / entacapone
  • Pill
  • Pill
Used for
entacaponecarbidopa / levodopa / entacapone
Risk factors for serious side effects
entacaponecarbidopa / levodopa / entacapone
  • Taking other medicines for Parkinson's
  • Low blood pressure
  • Taking medicines for high blood pressure
  • Taking other medicines for Parkinson's disease
Detailed Comtan (entacapone) risks & warnings »
  • History of stomach ulcers
Detailed Stalevo (carbidopa / levodopa / entacapone) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Sleep
entacaponecarbidopa / levodopa / entacapone
  • Can make you very sleepy
  • Can make you very sleepy. Don't drive or do anything requiring concentration until you know how it affects you.
  • Comtan (entacapone) can make you very sleepy. Don't drive or do anything that requires your full concentration until you know how Comtan (entacapone) affects you. This is more likely if you're also taking other medicines for Parkinson's. Talk to your doctor if this bothers you.
No sleep related info.
Upsides and benefits
entacaponecarbidopa / levodopa / entacapone
  • Allows you to get more out of carbidopa/levodopa, especially in later stages of Parkinson's disease.
  • Comtan (entacapone) is available in a single pill combination with carbidopa/levodopa.
  • It combines three medicines into one pill so you don't have to take so many pills daily.
  • Stalevo (carbidopa / levodopa / entacapone) is available as a generic.
Downsides and risks
entacaponecarbidopa / levodopa / entacapone
  • Must be taken with other medicines for Parkinson's disease
  • Can make you lightheaded especially if you suddenly stand up from sitting or lying down.
  • Can make you very sleepy
  • May require frequent adjustments before finding the dose that works best for you
  • You would first start by taking Stalevo (carbidopa / levodopa / entacapone) as two different pills, carbidopa/levodopa and entacapone, before you get switched over to Stalevo (carbidopa / levodopa / entacapone).
  • It's less customizable since there are only a few fixed combinations available.
Tips from our pharmacists for people taking the medication
entacaponecarbidopa / levodopa / entacapone
  • Doesn't work by itself. Must be taken with other medicines for Parkinson's disease
  • Can make you lightheaded especially if you suddenly stand up from sitting or lying down.
  • Can make you very sleepy. Don't drive or do anything requiring concentration until you know how it affects you.
  • May cause an upset stomach
  • May require frequent adjusting until you the dose that works best
  • Stalevo (carbidopa / levodopa / entacapone) can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
  • Your saliva, sweat and urine may have dark color and stain your clothing while taking Stalevo (carbidopa / levodopa / entacapone).
  • Take Stalevo (carbidopa / levodopa / entacapone) 30-60 minutes before a meal so that your body can properly absorb it. Don't eat too much high protein foods (meat, milk, cheese or nuts) because doing so can prevent it from getting absorbed into your body.
  • Stalevo (carbidopa / levodopa / entacapone) may cause unusual cravings in some people.
Learn more
More about entacaponeSide effectsAlternativesFDA package insert
Have you used Comtan (entacapone)?
Worth itNot sureNot worth it
More about carbidopa / levodopa / entacaponeSide effectsAlternativesFDA package insert
Have you used Stalevo (carbidopa / levodopa / entacapone)?
Worth itNot sureNot worth it