Compare entacapone vs. carbidopa/levodopa extended release

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Comtan
(entacapone)

Sinemet CR
(carbidopa / levodopa extended release)

Treats Parkinson's disease. Comtan (entacapone) enhances the effect of carbidopa/levodopa. It's usually added on when carbidopa/levodopa starts to lose its effect on Parkinson's disease.Treats Parkinson's disease. Sinemet CR (carbidopa / levodopa extended release) is the first choice treatment for Parkinson's disease.
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Reviews & ratings
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Have you used Comtan (entacapone)?
Worth itNot sureNot worth it

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Have you used Sinemet CR (carbidopa / levodopa extended release)?
Worth itNot sureNot worth it
Side effects
entacaponecarbidopa/levodopa extended release
  • Difficulty controlling movements 10%
  • Nausea 6%
  • Muscle spasm 5%
  • Changes in urine color 10%
  • Diarrhea 6%
  • Muscle rigidity 1%
  • Dizziness 2%
  • Abdominal pain 4%
  • Fatigue 2%
  • Constipation 2%
More entacapone side effects »
  • Difficulty controlling movements 17%
  • Nausea 6%
  • Hallucinations 4%
  • Confusion 4%
  • Dizziness 3%
  • Low mood disorder 2%
  • Urinary tract infection 2%
  • Back pain 2%
  • Unusual dreams 2%
  • Muscle spasms 2%
More carbidopa/levodopa extended release side effects »
How it works
entacaponecarbidopa/levodopa extended release
Comtan (entacapone) is a COMT inhibitor. It prevents levodopa from breaking down before it enters the brain.Sinemet CR (carbidopa / levodopa extended release) is a combination of carbidopa and levodopa that is released in your body over time. Carbidopa prevents breakdown of levodopa so that levodopa can then, enter the brain and relieve symptoms of Parkinson's disease.
Type of medication
entacaponecarbidopa/levodopa extended release
Prescription only
Prescription only
Available as
entacaponecarbidopa/levodopa extended release
  • Pill
  • Extended release
Used for
entacaponecarbidopa/levodopa extended release
Risk factors for serious side effects
entacaponecarbidopa/levodopa extended release
  • Taking other medicines for Parkinson's
    • Low blood pressure
    • Taking medicines for high blood pressure
    • Taking other medicines for Parkinson's disease
        Detailed Comtan (entacapone) risks & warnings »
        • Taking other medicines for Parkinson's
        • Stopping Sinemet CR (carbidopa / levodopa extended release) suddenly
          • Taking other medicines for Parkinson's disease
            Detailed Sinemet CR (carbidopa / levodopa extended release) risks & warnings »
            Pregnancy

            Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

            Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

            Sleep
            entacaponecarbidopa/levodopa extended release
            • Can make you very sleepy
            • Can make you very sleepy. Don't drive or do anything requiring concentration until you know how it affects you.
            • Comtan (entacapone) can make you very sleepy. Don't drive or do anything that requires your full concentration until you know how Comtan (entacapone) affects you. This is more likely if you're also taking other medicines for Parkinson's. Talk to your doctor if this bothers you.
            No sleep related info.
            Upsides and benefits
            entacaponecarbidopa/levodopa extended release
            • Allows you to get more out of carbidopa/levodopa, especially in later stages of Parkinson's disease.
            • Comtan (entacapone) is available in a single pill combination with carbidopa/levodopa.
            • Sinemet CR (carbidopa / levodopa extended release) is released over a long period of time in your body and can allow you to take fewer pills less frequently.
            Downsides and risks
            entacaponecarbidopa/levodopa extended release
            • Must be taken with other medicines for Parkinson's disease
            • Can make you lightheaded especially if you suddenly stand up from sitting or lying down.
            • Can make you very sleepy
            • May require frequent adjustments before finding the dose that works best for you
            • Sinemet CR (carbidopa / levodopa extended release) can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
            • Your saliva, sweat and urine may have dark color and stain your clothing while taking Sinemet CR (carbidopa / levodopa extended release).
            • Sinemet CR (carbidopa / levodopa extended release) will lose its effect over time. If you notice it wearing off sooner than you'd like, talk to your doctor.
            • Sinemet CR (carbidopa / levodopa extended release) may cause unusual cravings in some people.
            Tips from our pharmacists for people taking the medication
            entacaponecarbidopa/levodopa extended release
            • Doesn't work by itself. Must be taken with other medicines for Parkinson's disease
            • Can make you lightheaded especially if you suddenly stand up from sitting or lying down.
            • Can make you very sleepy. Don't drive or do anything requiring concentration until you know how it affects you.
            • May cause an upset stomach
            • May require frequent adjusting until you the dose that works best
            • Sinemet CR (carbidopa / levodopa extended release) can make you very sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
            • Your saliva, sweat and urine may have dark color and stain your clothing while taking Sinemet CR (carbidopa / levodopa extended release).
            • Take Sinemet CR (carbidopa / levodopa extended release) 30-60 minutes before a meal so that your body can properly absorb it. Don't eat too much high protein foods (meat, milk, cheese or nuts) because doing so can prevent it from getting absorbed into your body.
            • Sinemet CR (carbidopa / levodopa extended release) may cause unusual cravings in some people.
            Learn more
            More about entacaponeSide effectsAlternativesFDA package insert
            Have you used Comtan (entacapone)?
            Worth itNot sureNot worth it
            More about carbidopa/levodopa extended releaseSide effectsAlternativesFDA package insert
            Have you used Sinemet CR (carbidopa / levodopa extended release)?
            Worth itNot sureNot worth it