Compare entacapone vs. Eldepryl

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Comtan
(entacapone)

Eldepryl
(selegiline)

Treats Parkinson's disease. Comtan (entacapone) enhances the effect of carbidopa/levodopa. It's usually added on when carbidopa/levodopa starts to lose its effect on Parkinson's disease.Treats Parkinson's disease. Used with other medicines for Parkinson's disease to boost its effect.
Reviews & ratings
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Have you used Comtan (entacapone)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Eldepryl (selegiline)?
Worth itNot sureNot worth it
Side effects
entacaponeEldepryl
  • Difficulty controlling movements 10%
  • Nausea 6%
  • Muscle spasm 5%
  • Changes in urine color 10%
  • Diarrhea 6%
  • Muscle rigidity 1%
  • Dizziness 2%
  • Abdominal pain 4%
  • Fatigue 2%
  • Constipation 2%
More entacapone side effects »
  • Skin irritation at the patch 12%
  • Headache 1%
  • Insomnia 5%
  • Diarrhea 2%
  • Dry mouth 2%
  • Weight loss of at least 5% 2%
  • Indigestion 1%
  • Rash 2%
  • Sinus infection 2%
  • Sore throat 1%
More Eldepryl side effects »
How it works
entacaponeEldepryl
Comtan (entacapone) is a COMT inhibitor. It prevents levodopa from breaking down before it enters the brain.Eldepryl (selegiline) is a selective monoamine oxidase inhibitor. It regulates the amount of dopamine in your body.
Type of medication
entacaponeEldepryl
Prescription onlyPrescription only
Available as
entacaponeEldepryl
  • Pill
  • Pill
  • Dissolving tablet
Used for
entacaponeEldepryl
Risk factors for serious side effects
entacaponeEldepryl
  • Taking other medicines for Parkinson's
  • Low blood pressure
  • Taking medicines for high blood pressure
  • Taking other medicines for Parkinson's disease
Detailed Comtan (entacapone) risks & warnings »
  • Eating foods rich in tyramine, like soy sauce, fermented cheese and smoked meats
  • Taking cough and cold medicines like dextromethorphan (Robitussin DM), pseudoephedrine (Sudafed)
  • Tricyclic antidepressants
  • Fentanyl
  • Tramadol
Detailed Eldepryl (selegiline) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
entacaponeEldepryl
No food related info.
  • Avoid eating foods high in tyramine while taking Eldepryl (selegiline), since it can increase your blood pressure.
Sleep
entacaponeEldepryl
  • Comtan (entacapone) can make you very sleepy. Don't drive or do anything that requires your full concentration until you know how Comtan (entacapone) affects you. This is more likely if you're also taking other medicines for Parkinson's. Talk to your doctor if this bothers you.
  • Can make you very sleepy. Don't drive or do anything requiring concentration until you know how it affects you.
  • Can make you very sleepy
No sleep related info.
Upsides and benefits
entacaponeEldepryl
  • Allows you to get more out of carbidopa/levodopa, especially in later stages of Parkinson's disease.
  • Comtan (entacapone) is available in a single pill combination with carbidopa/levodopa.
  • There are two different versions of Eldepryl (selegiline), a quick dissolving tablet and a regular tablet.
  • Eldepryl (selegiline) is one of the recommended medicines you can take along with carbidopa/levodopa if your Parkinson's disease is getting worse.
Downsides and risks
entacaponeEldepryl
  • Must be taken with other medicines for Parkinson's disease
  • Can make you lightheaded especially if you suddenly stand up from sitting or lying down.
  • Can make you very sleepy
  • May require frequent adjustments before finding the dose that works best for you
  • You may have to limit the amount of cheese, smoked meat, and soy sauce you eat while taking Eldepryl (selegiline) since it can raise your blood pressure.
  • Can keep you up at night if you take it later in the day
  • Doesn't work by itself to treat Parkinson's disease.
Tips from our pharmacists for people taking the medication
entacaponeEldepryl
  • Doesn't work by itself. Must be taken with other medicines for Parkinson's disease
  • Can make you lightheaded especially if you suddenly stand up from sitting or lying down.
  • Can make you very sleepy. Don't drive or do anything requiring concentration until you know how it affects you.
  • May cause an upset stomach
  • May require frequent adjusting until you the dose that works best
  • Watch how much smoked meat, cheese, pickles and soy sauce you eat while taking Eldepryl (selegiline) since it can raise your blood pressure.
  • Avoid taking your doses later in the day because it can keep you up.
  • Don't stop Eldepryl (selegiline) suddenly without talking to your doctor, since it can be dangerous.
Learn more
More about entacaponeSide effectsAlternativesFDA package insert
Have you used Comtan (entacapone)?
Worth itNot sureNot worth it
More about EldeprylSide effectsAlternativesFDA package insert
Have you used Eldepryl (selegiline)?
Worth itNot sureNot worth it