Compare entacapone vs. Emsam

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Comtan
(entacapone)

Eldepryl
(selegiline)

Treats Parkinson's disease. Comtan (entacapone) enhances the effect of carbidopa/levodopa. It's usually added on when carbidopa/levodopa starts to lose its effect on Parkinson's disease.Coming soon.
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Coupons for entacapone
Best available price for 90 (200mg) tablets of entacapone
Coupons for Emsam
Best available price for 60 (5mg) tablets of selegiline
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
Reviews for Comtan (entacapone)
Not enough review data. Review it!
of people (All ages) say Comtan (entacapone) is worth it
Not enough review data. Review it!
say it works well
Not enough review data. Review it!
say it's a big hassle
Have you used Comtan (entacapone)?
Worth itNot sureNot worth it
Reviews for Eldepryl (selegiline)
Not enough review data. Review it!
Same vs. Comtan (entacapone)
Not enough review data. Review it!
Same vs. Comtan (entacapone)
Not enough review data. Review it!
-80% worse vs. Comtan (entacapone)
Have you used Eldepryl (selegiline)?
Worth itNot sureNot worth it
Side effects
entacaponeEmsam
  • Difficulty controlling movements 10%
  • Nausea 6%
  • Muscle spasm 5%
  • Changes in urine color 10%
  • Diarrhea 6%
  • Muscle rigidity 1%
  • Dizziness 2%
  • Abdominal pain 4%
  • Fatigue 2%
  • Constipation 2%
More entacapone side effects »

We haven’t found good data for Emsam side effects.

FDA side effect reports for Emsam »
How it works
entacaponeEmsam
Comtan (entacapone) is a COMT inhibitor. It prevents levodopa from breaking down before it enters the brain.Coming soon.
Type of medication
entacaponeEmsam
Prescription only
Available as
entacaponeEmsam
  • Pill
  • Pill
  • Patch
Used for
entacaponeEmsam
  • Major Depressive Disorder
Risk factors for serious side effects
entacaponeEmsam
  • Taking other medicines for Parkinson's
  • Low blood pressure
  • Taking medicines for high blood pressure
  • Taking other medicines for Parkinson's disease
Detailed Comtan (entacapone) risks & warnings »
    Coming soon.
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Sleep
    entacaponeEmsam
    • Can make you very sleepy
    • Can make you very sleepy. Don't drive or do anything requiring concentration until you know how it affects you.
    • Comtan (entacapone) can make you very sleepy. Don't drive or do anything that requires your full concentration until you know how Comtan (entacapone) affects you. This is more likely if you're also taking other medicines for Parkinson's. Talk to your doctor if this bothers you.
    No sleep related info.
    Upsides and benefits
    entacaponeEmsam
    • Allows you to get more out of carbidopa/levodopa, especially in later stages of Parkinson's disease.
    • Comtan (entacapone) is available in a single pill combination with carbidopa/levodopa.
    Coming soon
    Downsides and risks
    entacaponeEmsam
    • Must be taken with other medicines for Parkinson's disease
    • Can make you lightheaded especially if you suddenly stand up from sitting or lying down.
    • Can make you very sleepy
    • May require frequent adjustments before finding the dose that works best for you
    Coming soon
    Tips from our pharmacists for people taking the medication
    entacaponeEmsam
    • Doesn't work by itself. Must be taken with other medicines for Parkinson's disease
    • Can make you lightheaded especially if you suddenly stand up from sitting or lying down.
    • Can make you very sleepy. Don't drive or do anything requiring concentration until you know how it affects you.
    • May cause an upset stomach
    • May require frequent adjusting until you the dose that works best
    Coming soon
    Learn more
    More about entacaponeSide effectsAlternativesFDA package insert
    Have you used Comtan (entacapone)?
    Worth itNot sureNot worth it
    More about EmsamSide effectsReviews & ratingsFDA package insert
    Have you used Eldepryl (selegiline)?
    Worth itNot sureNot worth it