Compare entacapone vs. Mirapex

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Comtan
(entacapone)

Mirapex
(Pramipexole)

Treats Parkinson's disease. Comtan (entacapone) enhances the effect of carbidopa/levodopa. It's usually added on when carbidopa/levodopa starts to lose its effect on Parkinson's disease.Helps with movement problems. Mirapex (Pramipexole) is an effective medicine for Parkinson's disease or restless leg syndrome, but there are potentially serious side effects.
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Reviews & ratings
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Have you used Comtan (entacapone)?
Worth itNot sureNot worth it

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Have you used Mirapex (Pramipexole)?
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Side effects
entacaponeMirapex
  • Difficulty controlling movements 10%
  • Nausea 6%
  • Muscle spasm 5%
  • Changes in urine color 10%
  • Diarrhea 6%
  • Muscle rigidity 1%
  • Dizziness 2%
  • Abdominal pain 4%
  • Fatigue 2%
  • Constipation 2%
More entacapone side effects »
  • Nausea 14%
  • Flu 3%
  • Nasal congestion 2%
  • Pain in extremity 2%
  • Any side effect 1%
  • Hallucinations 3%
  • Dizziness 1%
  • Drowsiness 2%
More Mirapex side effects »
How it works
entacaponeMirapex
Comtan (entacapone) is a COMT inhibitor. It prevents levodopa from breaking down before it enters the brain.Mirapex (Pramipexole) is a dopamine agonist. It binds to receptors in the brain and helps improve movement in people with Parkinson's disease or restless leg syndrome.
Type of medication
entacaponeMirapex
Prescription only
Prescription only
Available as
entacaponeMirapex
  • Pill
  • Pill
  • Extended release
Used for
entacaponeMirapex
Risk factors for serious side effects
entacaponeMirapex
  • Taking other medicines for Parkinson's
    • Low blood pressure
    • Taking medicines for high blood pressure
    • Taking other medicines for Parkinson's disease
        Detailed Comtan (entacapone) risks & warnings »
          • Taking with alcohol
          • Taking other medicines that make you less alert
          • Taking blood pressure-lowering medicines
          • Current kidney problems
          • Parkinson's disease
          • Age 65 years or older
          Detailed Mirapex (Pramipexole) risks & warnings »
          Pregnancy

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          Food
          entacaponeMirapex
          No food related info.
          • Take Mirapex (Pramipexole) with food if it makes you feel nauseous.
          Kidneys and liver
          entacaponeMirapex
          No kidneys and liver related info.
          • Not the best choice if you have kidney problems. Your doctor may have to adjust your dose based on your kidney function.
          • Mirapex (Pramipexole) is processed by the kidney. If you have kidney problems, talk to your doctor because you may need a different dose.
          Sleep
          entacaponeMirapex
          • Can make you very sleepy
          • Can make you very sleepy. Don't drive or do anything requiring concentration until you know how it affects you.
          • Comtan (entacapone) can make you very sleepy. Don't drive or do anything that requires your full concentration until you know how Comtan (entacapone) affects you. This is more likely if you're also taking other medicines for Parkinson's. Talk to your doctor if this bothers you.
          No sleep related info.
          Upsides and benefits
          entacaponeMirapex
          • Allows you to get more out of carbidopa/levodopa, especially in later stages of Parkinson's disease.
          • Comtan (entacapone) is available in a single pill combination with carbidopa/levodopa.
          • In studies, Mirapex (Pramipexole) when taken by itself or with other medicines, was effective in lowering movement fluctuations for people with Parkinson's disease.
          • Mirapex (Pramipexole) is sometimes preferred over other medicines that treat Parkinson's disease in older people since it causes fewer movement and mental fluctuations.
          • Is effective for treating restless leg syndrome.
          • Available in a short-acting and a long-acting form.
          Downsides and risks
          entacaponeMirapex
          • Must be taken with other medicines for Parkinson's disease
          • Can make you lightheaded especially if you suddenly stand up from sitting or lying down.
          • Can make you very sleepy
          • May require frequent adjustments before finding the dose that works best for you
          • Mirapex (Pramipexole) isn't a first-choice treatment for Parkinson's disease. It can be used by itself, but it's usually used with other medicines.
          • Mirapex (Pramipexole) can cause hallucinations in older people.
          • Not the best choice if you have kidney problems. Your doctor may have to adjust your dose based on your kidney function.
          • You can't suddenly stop taking Mirapex (Pramipexole). You'll have to slowly lower your dose, especially if you've been using it for a long time.
          Tips from our pharmacists for people taking the medication
          entacaponeMirapex
          • Doesn't work by itself. Must be taken with other medicines for Parkinson's disease
          • Can make you lightheaded especially if you suddenly stand up from sitting or lying down.
          • Can make you very sleepy. Don't drive or do anything requiring concentration until you know how it affects you.
          • May cause an upset stomach
          • May require frequent adjusting until you the dose that works best
          • You should start Mirapex (Pramipexole) at a low dose and your doctor will raise the dose slowly. This will help lower your risk of side effects, such as drowsiness and low blood pressure.
          • Can cause intense urges and compulsive behaviors that are hard to control, such as binge eating, gambling, and sexual urges. Talk to your doctor right away if you have any of these feelings.
          • You can suddenly fall asleep without warning while on this medicine. Don't perform any tasks that require mental alertness, like driving, or drinking alcohol until you know how Mirapex (Pramipexole) affects you. Let your doctor know if you have a history of sleep problems.
          • Take Mirapex (Pramipexole) 2 to 3 hours before bedtime for restless leg syndrome.
          • Take Mirapex (Pramipexole) with food if it makes you feel nauseous.
          Learn more
          More about entacaponeSide effectsAlternativesFDA package insert
          Have you used Comtan (entacapone)?
          Worth itNot sureNot worth it
          More about MirapexSide effectsReviews & ratingsAlternativesFDA package insert
          Have you used Mirapex (Pramipexole)?
          Worth itNot sureNot worth it