Compare entacapone vs. Mirapex

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Comtan (entacapone)

Prescription only

Mirapex (Pramipexole)

Prescription only
Treats Parkinson's disease.

Comtan (entacapone) enhances the effect of carbidopa/levodopa. It's usually added on when carbidopa/levodopa starts to lose its effect on Parkinson's disease.

Helps with movement problems.

Mirapex (Pramipexole) is an effective medicine for Parkinson's disease or restless leg syndrome, but there are potentially serious side effects.

Upsides
  • Allows you to get more out of carbidopa/levodopa, especially in later stages of Parkinson's disease.
  • Comtan (entacapone) is available in a single pill combination with carbidopa/levodopa.
  • In studies, Mirapex (Pramipexole) when taken by itself or with other medicines, was effective in lowering movement fluctuations for people with Parkinson's disease.
  • Mirapex (Pramipexole) is sometimes preferred over other medicines that treat Parkinson's disease in older people since it causes fewer movement and mental fluctuations.
  • Is effective for treating restless leg syndrome.
  • Available in a short-acting and a long-acting form.
Downsides
  • Must be taken with other medicines for Parkinson's disease
  • Can make you lightheaded especially if you suddenly stand up from sitting or lying down.
  • Can make you very sleepy
  • May require frequent adjustments before finding the dose that works best for you
  • Mirapex (Pramipexole) isn't a first-choice treatment for Parkinson's disease. It can be used by itself, but it's usually used with other medicines.
  • Mirapex (Pramipexole) can cause hallucinations in older people.
  • Not the best choice if you have kidney problems. Your doctor may have to adjust your dose based on your kidney function.
  • You can't suddenly stop taking Mirapex (Pramipexole). You'll have to slowly lower your dose, especially if you've been using it for a long time.
Used for
Dosage forms
  • Pill
  • Pill
  • Extended release
Price
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Reviews
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Side effects
21possible side effects
  • Difficulty controlling movements
    25%
  • Nausea
    14%
  • Muscle spasm
    10%
  • Changes in urine color
    10%
  • Diarrhea
    10%
  • Muscle rigidity
    9%
  • Dizziness
    8%
  • Abdominal pain
    8%
  • Fatigue
    6%
  • Constipation
    6%
  • Vomiting
    4%
  • Dry mouth
    3%
  • Shortness of breath
    3%
  • Purple spots on the skin
    3%
  • Increased sweating
    2%
  • Back pain
    2%
  • Anxiety
    2%
  • Sleepiness
    2%
  • Indigestion
    2%
  • Flatulence
    2%
  • Weakness
    2%
See more detailed side effects
45possible side effects
  • Postural hypotension
    53%
  • Dyskinesia
    47%
  • Extrapyramidal syndrome
    28%
  • Insomnia
    27%
  • Dizziness
    26%
  • Accidental injury
    17%
  • Hallucinations
    17%
  • Any side effect
    12%
  • Dream abnormalities
    11%
  • Nausea
    11%
  • Asthenia
    10%
  • Constipation
    10%
  • Confusion
    10%
  • Somnolence
    9%
  • Hallucinations, including visual, auditory and mixed
    9%
  • Dystonia
    8%
  • Dry mouth
    7%
  • Gait abnormalities
    7%
  • Hypertonia
    7%
  • Headache
    7%
  • Amnesia
    6%
  • Urinary frequency
    6%
  • Anorexia
    5%
  • General edema
    4%
  • Dyspnea
    4%
  • Accommodation abnormalities
    4%
  • Urinary tract infection
    4%
  • Chest pain
    3%
  • Malaise
    3%
  • Arthritis
    3%
  • Akathisia
    3%
  • Thinking abnormalities
    3%
  • Rhinitis
    3%
  • Vision abnormalities
    3%
  • Dizziness (postural)
    3%
  • Back pain
    3%
  • Peripheral edema
    2%
  • Twitching
    2%
  • Bursitis
    2%
  • Paranoid reaction
    2%
  • Pneumonia
    2%
  • Skin disorders
    2%
  • Urinary incontinence
    2%
  • Salivary hypersecretion
    2%
  • Diarrhea
    2%
See more detailed side effects
Risks and risk factors
  • Falling asleep during the day
    • Taking other medicines for Parkinson's
  • Changes in behavior
  • Low blood pressure and fainting
    • Low blood pressure
    • Taking medicines for high blood pressure
  • Lack of impulse control
    • Taking other medicines for Parkinson's disease
  • Diarrhea
  • Difficulty controlling movements
See more detailed risks and warnings
  • Impulse control problems
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
  • Low blood pressure
    • Taking blood pressure-lowering medicines
  • Worsening kidney function
    • Current kidney problems
  • Skin cancer
    • Parkinson's disease
  • Hallucinations
    • Age 65 years or older
See more detailed risks and warnings