Compare entacapone vs. Rytary

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Comtan
(entacapone)

Rytary
(carbidopa / levodopa)

Treats Parkinson's disease. Comtan (entacapone) enhances the effect of carbidopa/levodopa. It's usually added on when carbidopa/levodopa starts to lose its effect on Parkinson's disease.Treats Parkinson's disease. Rytary (carbidopa / levodopa) can be used to treat Parkinson's disease, but it can be expensive.
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Reviews & ratings
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Have you used Comtan (entacapone)?
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Have you used Rytary (carbidopa / levodopa)?
Worth itNot sureNot worth it
Side effects
entacaponeRytary
  • Difficulty controlling movements 10%
  • Nausea 6%
  • Muscle spasm 5%
  • Changes in urine color 10%
  • Diarrhea 6%
  • Muscle rigidity 1%
  • Dizziness 2%
  • Abdominal pain 4%
  • Fatigue 2%
  • Constipation 2%
More entacapone side effects »
  • Nausea 5%
  • Dizziness 4%
  • Dry mouth 2%
  • Abnormal dreams 2%
  • Difficulty controlling movements 2%
  • Anxiety 2%
  • Constipation 1%
More Rytary side effects »
How it works
entacaponeRytary
Comtan (entacapone) is a COMT inhibitor. It prevents levodopa from breaking down before it enters the brain.Rytary (carbidopa / levodopa) is a combination of carbidopa and levodopa. Levodopa enters the brain and relieves the symptoms of Parkinson's disease. Carbidopa prevents levodopa from being broken down before it can enter the brain.
Type of medication
entacaponeRytary
Prescription only
Prescription only
Available as
entacaponeRytary
  • Pill
  • Extended release capsule
Used for
entacaponeRytary
Risk factors for serious side effects
entacaponeRytary
  • Taking other medicines for Parkinson's
    • Low blood pressure
    • Taking medicines for high blood pressure
    • Taking other medicines for Parkinson's disease
        Detailed Comtan (entacapone) risks & warnings »
        • Taking other medicines for Parkinson's disease
        • Stopping Rytary (carbidopa / levodopa) suddenly
          • Taking other medicines for Parkinson's disease
          • History of heart attack
          • High risk for heart attack
          Detailed Rytary (carbidopa / levodopa) risks & warnings »
          Pregnancy

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          Sleep
          entacaponeRytary
          • Can make you very sleepy
          • Can make you very sleepy. Don't drive or do anything requiring concentration until you know how it affects you.
          • Comtan (entacapone) can make you very sleepy. Don't drive or do anything that requires your full concentration until you know how Comtan (entacapone) affects you. This is more likely if you're also taking other medicines for Parkinson's. Talk to your doctor if this bothers you.
          • Rytary (carbidopa / levodopa) can make you sleepy or fall asleep suddenly without warning. Don't drive or do anything that requires concentration until you know how Rytary (carbidopa / levodopa) affects you. You're more at risk if you're taking other medicines for Parkinson's disease. Talk to your doctor if this bothers you.
          Upsides and benefits
          entacaponeRytary
          • Allows you to get more out of carbidopa/levodopa, especially in later stages of Parkinson's disease.
          • Comtan (entacapone) is available in a single pill combination with carbidopa/levodopa.
          • Rytary (carbidopa / levodopa) comes in 4 different strengths.
          • If you have private prescription insurance, there are programs to make Rytary (carbidopa / levodopa) more affordable.
          Downsides and risks
          entacaponeRytary
          • Must be taken with other medicines for Parkinson's disease
          • Can make you lightheaded especially if you suddenly stand up from sitting or lying down.
          • Can make you very sleepy
          • May require frequent adjustments before finding the dose that works best for you
          • There are other forms of Rytary (carbidopa / levodopa) that are generic and much cheaper.
          • Your doctor might have to change the dose of Rytary (carbidopa / levodopa) often before they find a dose that works for you.
          • Rytary (carbidopa / levodopa) can cause uncontrollable movements to happen, but this doesn't happen for 3 to 5 years.
          • Rytary (carbidopa / levodopa) is not a cure for Parkinson's disease; it can only slow the disease down.
          Tips from our pharmacists for people taking the medication
          entacaponeRytary
          • Doesn't work by itself. Must be taken with other medicines for Parkinson's disease
          • Can make you lightheaded especially if you suddenly stand up from sitting or lying down.
          • Can make you very sleepy. Don't drive or do anything requiring concentration until you know how it affects you.
          • May cause an upset stomach
          • May require frequent adjusting until you the dose that works best
          • If you can't swallow the capsules whole, they can be sprinkled on 1 to 2 tablespoons of applesauce. You have to take it right away.
          • Don't drive or do anything requiring concentration until you know how Rytary (carbidopa / levodopa) affects you.
          • You can't switch off other forms of carbidopa/levodopa to Rytary (carbidopa / levodopa) without talking to your doctor or pharmacist. They'll tell you how to do it safely.
          Learn more
          More about entacaponeSide effectsAlternativesFDA package insert
          Have you used Comtan (entacapone)?
          Worth itNot sureNot worth it
          More about RytarySide effectsAlternativesFDA package insert
          Have you used Rytary (carbidopa / levodopa)?
          Worth itNot sureNot worth it