Compare entacapone vs. tolcapone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Comtan
(entacapone)

Tasmar
(tolcapone)

Treats Parkinson's disease. Comtan (entacapone) enhances the effect of carbidopa/levodopa. It's usually added on when carbidopa/levodopa starts to lose its effect on Parkinson's disease.Treats Parkinson's disease. Taking Tasmar (tolcapone) is the next step to control Parkinson's disease when carbidopa/levodopa don't work as well, however you might be more likely to have liver damage.
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Reviews & ratings
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Have you used Comtan (entacapone)?
Worth itNot sureNot worth it

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Have you used Tasmar (tolcapone)?
Worth itNot sureNot worth it
Side effects
entacaponetolcapone
  • Difficulty controlling movements 10%
  • Nausea 6%
  • Muscle spasm 5%
  • Changes in urine color 10%
  • Diarrhea 6%
  • Muscle rigidity 1%
  • Dizziness 2%
  • Abdominal pain 4%
  • Fatigue 2%
  • Constipation 2%
More entacapone side effects »
  • Difficulty controlling movement 22%
  • Nausea 12%
  • Sleeping problems 6%
  • Excessive dreaming 4%
  • Muscle cramps 2%
  • Loss of appetite 6%
  • Sleepiness 5%
  • Lightheadedness from standing 3%
  • Diarrhea 8%
More tolcapone side effects »
How it works
entacaponetolcapone
Comtan (entacapone) is a COMT inhibitor. It prevents levodopa from breaking down before it enters the brain.Tasmar (tolcapone) is an enzyme inhibitor that stops levodopa from being broken down. It causes higher levodopa in the brain, which relieves the symptoms of Parkinson's disease.
Type of medication
entacaponetolcapone
Prescription only
Prescription only
Available as
entacaponetolcapone
  • Pill
  • Pill
Used for
entacaponetolcapone
Risk factors for serious side effects
entacaponetolcapone
  • Taking other medicines for Parkinson's
    • Low blood pressure
    • Taking medicines for high blood pressure
    • Taking other medicines for Parkinson's disease
        Detailed Comtan (entacapone) risks & warnings »
        • Liver damage
        • Taking other medicines for Parkinson's disease
          • Taking antipsychotic medicines
            • Taking other medicines for Parkinson's disease
            Detailed Tasmar (tolcapone) risks & warnings »
            Pregnancy

            Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

            Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

            Food
            entacaponetolcapone
            No food related info.
            • Tasmar (tolcapone) can be taken with or without food.
            Sleep
            entacaponetolcapone
            • Can make you very sleepy
            • Can make you very sleepy. Don't drive or do anything requiring concentration until you know how it affects you.
            • Comtan (entacapone) can make you very sleepy. Don't drive or do anything that requires your full concentration until you know how Comtan (entacapone) affects you. This is more likely if you're also taking other medicines for Parkinson's. Talk to your doctor if this bothers you.
            No sleep related info.
            Upsides and benefits
            entacaponetolcapone
            • Allows you to get more out of carbidopa/levodopa, especially in later stages of Parkinson's disease.
            • Comtan (entacapone) is available in a single pill combination with carbidopa/levodopa.
            • Tasmar (tolcapone) is part of the medicines used as the most common next step to control Parkinson's disease when carbidopa/levodopa doesn't work as well.
            • Tasmar (tolcapone) is available as a generic.
            • Tasmar (tolcapone) can be taken with or without food.
            Downsides and risks
            entacaponetolcapone
            • Must be taken with other medicines for Parkinson's disease
            • Can make you lightheaded especially if you suddenly stand up from sitting or lying down.
            • Can make you very sleepy
            • May require frequent adjustments before finding the dose that works best for you
            • When you first start taking Tasmar (tolcapone), your doctor might have to change the dose a lot because of all the side effects.
            • Tasmar (tolcapone) will only slow the disease down; it is not a cure for Parkinson's disease.
            • Unlike Comtan, Tasmar (tolcapone) is more likely to damage your liver, so you might need regular blood tests for the first few months.
            • Tasmar (tolcapone) is not available as a combination pill with carbidopa/levodopa, unlike Comtan.
            • Tasmar (tolcapone) can cause dry mouth and changes in blood pressure. Changes in blood pressure can make you feel faint and more likely to fall.
            Tips from our pharmacists for people taking the medication
            entacaponetolcapone
            • Doesn't work by itself. Must be taken with other medicines for Parkinson's disease
            • Can make you lightheaded especially if you suddenly stand up from sitting or lying down.
            • Can make you very sleepy. Don't drive or do anything requiring concentration until you know how it affects you.
            • May cause an upset stomach
            • May require frequent adjusting until you the dose that works best
            • Tasmar (tolcapone) can make you dizzy if you've been sitting or lying down for a while. Be very careful when getting up.
            • Don't drive or do anything requiring concentration until you know how Tasmar (tolcapone) affects you.
            • Your urine might be colored dark orange or brown while taking Tasmar (tolcapone). This is normal.
            • You have to keep taking carbidopa/levodopa with Tasmar (tolcapone). Tasmar (tolcapone) won't work by itself to control your Parkinson's disease.
            • Talk to your doctor if you want to stop taking Tasmar (tolcapone). Stopping it suddenly can be very dangerous.
            Learn more
            More about entacaponeSide effectsAlternativesFDA package insert
            Have you used Comtan (entacapone)?
            Worth itNot sureNot worth it
            More about tolcaponeSide effectsAlternativesFDA package insert
            Have you used Tasmar (tolcapone)?
            Worth itNot sureNot worth it