Epiduo vs. Minocycline

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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(Adapalene / Benzoyl Peroxide)


Coming soon.Treats bacterial infections. Solodyn (Minocycline) is an effective way to treat certain skin infections, acne, and rosacea, but you'll need to use barrier methods of birth control since it can make birth control pills less effective and cause birth defects.
How it works
Coming soon.Solodyn (Minocycline) is a tetracycline antibiotic. It stops bacteria by preventing them from reproducing and repairing themselves.
Type of medication
Coming soon.
Prescription only
Available as
  • Cream, gel, or ointment
  • Pill
  • Extended release
  • Extended release capsule
Used for (click to learn more)
  • Acne vulgaris
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
Side effects

We haven’t found good data for Epiduo side effects.

FDA side effect reports for Epiduo »

We haven’t found good data for Minocycline side effects.

FDA side effect reports for Minocycline »
Risk factors for serious side effects
Coming soon.
  • Age 8 years or younger
  • Using oral birth control pills
  • Long antibiotic treatment period
      • Women of childbearing age
      Detailed Solodyn (Minocycline) risks & warnings »
      Pregnancy category
      No specific alcohol-related info.No specific alcohol-related info.
      No specific food-related info.No specific food-related info.
      Kidneys and liver
      No specific kidneys and liver-related info.No specific kidneys and liver-related info.
      No specific sex-related info.No specific sex-related info.
      No specific sleep-related info.No specific sleep-related info.
      No specific weight-related info.No specific weight-related info.
      Upsides and benefits
      Coming soon.
      • Clinical studies show it's effective against MRSA, a common skin infection, and it's commonly used to treat acne and rosacea.
      • Available as a generic, so it should be reasonably priced.
      • Solodyn (Minocycline) is less likely to cause sunburn than other tetracycline antibiotics.
      • Bacteria are less likely to become resistant to Solodyn (Minocycline) than other tetracycline antibiotics.
      Downsides and risks
      Coming soon.
      • It can make birth control pills less effective, so people should use barrier methods of birth control like condoms or diaphragms while on Solodyn (Minocycline).
      • Can stain your teeth, mouth, and gums if you're using the tablets, or your skin if you're using the topical version, but this is temporary.
      Tips from our pharmacists for people taking the medication
      Coming soon.
      • Both men and women should use barrier methods of birth control while on Solodyn (Minocycline) since it can cause birth defects and make birth control pills less effective.
      • Can make you dizzy, so be careful if you're getting up from lying down or sitting. Don't drive until you know how it affects you.
      • Can stain your teeth, tongue and gums, but this is temporary.
      • Take this exactly how your doctor or pharmacist tells you until it's all gone.
      • Don't eat any dairy products or take any vitamins within 2 hours of taking Solodyn (Minocycline) because they can make the medication less effective.
      Learn more
      More about EpiduoSide effectsReviews & ratingsFDA package insert
      More about MinocyclineSide effectsReviews & ratingsAlternativesFDA package insert