Compare Epivir vs. Viread

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Epivir
(Lamivudine)

Viread
(Tenofovir)

Works with other medicines to treat HIV infection. lamivudine is currently one of the most popular drugs within the Nucleoside Reverse Transcriptase Inhibitor (NRTI) drug class.Works with other medicines to treat HIV infection. Also treats Hepatitis B Virus. tenofovir can be a good choice to take within the Nucleoside Reverse Transcriptase Inhibitor (NRTI) drug class. It may not be the best choice though for people with kidney problems.
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Reviews & ratings
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Side effects
EpivirViread

We haven’t found good data for Epivir side effects.

FDA side effect reports for Epivir »

We haven’t found good data for Viread side effects.

FDA side effect reports for Viread »
How it works
EpivirViread
lamivudine stops the replication of the human immunodeficiency virus (HIV) within important cells of the body by preventing the virus from taking over normal functions of the cell for its own purposes.tenofovir stops the replication of the human immunodeficiency virus (HIV) within important cells of the body by preventing the virus from taking over normal functions of the cell for its own purposes.
Type of medication
EpivirViread
Coming soon.
Coming soon.
Available as
EpivirViread
  • Pill
  • Liquid
  • Pill
  • Liquid
Used for (click to learn more)
EpivirViread
  • HIV infection
  • HIV infection
Risk factors for serious side effects
EpivirViread
  • Women
  • Obesity
  • Liver disease
        • HIV
        • Exposure to other infections
        • Start of a new HIV medication
        • Change in HIV therapy
        • HIV treatment
        Detailed Epivir (Lamivudine) risks & warnings »
        • Women
        • Obesity
        • Liver disease
          • Kidney damage
          • Prior bone fractures
          • Osteoporosis
          • HIV
          • Exposure to other infections
          • Start of a new HIV medication
          • Change in HIV therapy
          • HIV treatment
          Detailed Viread (Tenofovir) risks & warnings »
          Pregnancy category
          EpivirViread
          CFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          BFDA pregnancy category (Probably safe)

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          See the FDA package insert
          Alcohol
          No specific alcohol-related info.No specific alcohol-related info.
          Food
          No specific food-related info.
          • The tenofovir powder can't be mixed in a liquid, so mix into soft food like applesauce and yogurt.
          • Take tenofovir once a day, with or without food.
          Kidneys and liver
          • The dose of lamivudine needs to be lowered if you have kidney problems.
          • lamivudine can cause this rare but life-threatening condition. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. Baseline blood work for kidney and liver function are helpful to see if you can use lamivudine. It may not be a good choice for people with liver problems.
          • The dose of tenofovir depends on how your kidneys work. It is really important to consistently monitor them with your doctor.
          • Don't take other drugs that can hurt your kidneys while taking tenofovir without talking to your doctor. That sadly includes non-steroidal anti-inflammatory drugs (NSAIDs), like aspirin, Advil, and Aleve.
          • Work with your doctor to monitor your kidney function and bone mineral density regularly.
          • tenofovir can cause this rare but life-threatening condition. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. Baseline blood work for kidney and liver function are helpful to see if you can use tenofovir. It may not be a good choice for people with liver problems.
          • tenofovir is removed from the body by the kidney. Kidney (renal) damage, including cases of renal failure and Fanconi syndrome (injury to the tubes inside of the kidney), has been reported with the use of tenofovir. Your doctor must continually monitor the function of your kidneys while you are taking tenofovir.
          Sex
          No specific sex-related info.No specific sex-related info.
          Sleep
          No specific sleep-related info.No specific sleep-related info.
          Weight
          No specific weight-related info.No specific weight-related info.
          Upsides and benefits
          EpivirViread
          • lamivudine is available as a tablet and oral solution.
          • Can be taken once or twice a day.
          • One of the more popular drugs in its class.
          • lamivudine is contained in the following combination products: Combivir, Epzicom, and Trizivir.
          • Take tenofovir once a day, with or without food.
          • For people who can't swallow the tablet, take the powder instead.
          • tenofovir is used for HIV in kids 2 years and older, and chronic hepatitis B in kids 12 years and older.
          Downsides and risks
          EpivirViread
          • lamivudine should not be used with any other drugs containing Emtriva (emtricitabine) since both are so similar to each other.
          • Use with caution in kids with a history of pancreatitis (pancreas infection).
          • Most common side effects are headache, nausea, tiredness, congestion, diarrhea, and cough.
          • The dose of lamivudine needs to be lowered if you have kidney problems.
          • The tenofovir powder can't be mixed in a liquid, so mix into soft food like applesauce and yogurt.
          • The dose of tenofovir depends on how your kidneys work. It is really important to consistently monitor them with your doctor.
          Tips from our pharmacists for people taking the medication
          EpivirViread
          • The doses for lamivudine are different for HIV and Hepatitis B.
          • If being used for kids, the dose of lamivudine will continue to change as they grow, so keep in touch with their doctor.
          • Keep an eye out for any new symptoms or side effects you may start to feel while taking lamivudine and report them to your doctor.
          • Don't take other drugs that can hurt your kidneys while taking tenofovir without talking to your doctor. That sadly includes non-steroidal anti-inflammatory drugs (NSAIDs), like aspirin, Advil, and Aleve.
          • People with HIV should be tested for Hepatitis B virus (HBV) before starting tenofovir.
          • Similarly, patients with chronic hepatitis B, should be tested for HIV before starting tenofovir.
          • Decreases in bone mineral density can happen while taking tenofovir.
          • Work with your doctor to monitor your kidney function and bone mineral density regularly.
          Learn more
          More about EpivirSide effectsAlternativesFDA package insert
          More about VireadSide effectsAlternativesFDA package insert