Compare Erygel vs. Epiduo

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Akne-Mycin
(erythromycin)

Epiduo
(adapalene / benzoyl peroxide)

Topical treatment for acne. Akne-Mycin (Erythromycin) is a very common acne treatment you apply to the skin that may work better when combined with other topical medicines.Coming soon.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.55Erygel
Reviews for Erygel
46%
of people (All ages) say Erygel is worth it
34%
say it works well
19%
say it's a big hassle
Have you used Akne-Mycin (erythromycin)?
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Have you used Epiduo (adapalene / benzoyl peroxide)?
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Side effects
ErygelEpiduo
  • Burning 25%
More Erygel side effects »

We haven’t found good data for Epiduo side effects.

FDA side effect reports for Epiduo »
How it works
ErygelEpiduo
Akne-Mycin (Erythromycin) is a topical antibiotic. It fights bacteria that cause acne in oil (sebaceous) glands, and contains alcohol which dries out acne-affected areas.Coming soon.
Type of medication
ErygelEpiduo
Prescription only
Available as
ErygelEpiduo
  • Cream, gel, or ointment
  • Topical solution
  • Cream, gel, or ointment
Used for
ErygelEpiduo
  • Acne Vulgaris
Risk factors for serious side effects
ErygelEpiduo
  • Using other medicines or products that irritate the skin
  • Eczema
  • Extreme temperatures (hot or cold)
Detailed Akne-Mycin (erythromycin) risks & warnings »
    Coming soon.
    Pregnancy

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Pain
    ErygelEpiduo
    • Let your doctor know if you notice abdominal discomfort, pain or diarrhea after starting this medicine.
    No pain related info.
    Weight
    ErygelEpiduo
    • Better choice if you're pregnant. erythromycin is categorized as pregnancy Category B (likely safe) as compared to similar topical medicines that are Category C (weigh risks vs benefits).
    No weight related info.
    Upsides and benefits
    ErygelEpiduo
    • Applying erythromycin to the skin reduces the amount of acne bacteria and "calms" the skin down (lowers the inflammatory response) in acne.
    • Available in a gel formulation which may be better if your skin is very oily.
    • Better choice if you're pregnant. erythromycin is categorized as pregnancy Category B (likely safe) as compared to similar topical medicines that are Category C (weigh risks vs benefits).
    Coming soon
    Downsides and risks
    ErygelEpiduo
    • There's a risk of irritation with anything you apply to your skin and this is no different. erythromycin, like other topical antibiotics, can cause skin irritation and may appear as redness, peeling, abnormal dryness or stinging, tightening, or burning sensations.
    • It's rare, that a serious allergic reaction would occur, but it's a good idea to test a small area of skin before using on any larger or sensitive areas
    • Studies show it works better when combined with other topical medicines to fight acne and reduce the risk of it losing its effectiveness over time.
    • Can cause severe inflammation of the large intestine (pseudomembranous colitis)
    • Stop using if you don't notice any improvement in your acne after 6-8 weeks. The most time you can use it is three months.
    Coming soon
    Tips from our pharmacists for people taking the medication
    ErygelEpiduo
    • Very commonly used topical antibiotic to treat acne.
    • The only topical erythromycin in a gel formula.
    • Apply a thin film to clean and dry affected skin once or twice a day.
    • It may take 6-8 weeks before you see improvement in your acne.
    • Avoid getting into your eyes, nose or mouth.
    • Let your doctor know if you notice abdominal discomfort, pain or diarrhea after starting this medicine.
    • Using a moisturizer that doesn't block your pores (non-comedogenic) may help lessen common side effects of skin dryness and peeling.
    • Taking good care of your skin is an important part of treating acne. Lightly wash with warm water and non-soap-based or gentle cleanser.
    Coming soon
    Learn more
    More about ErygelSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Akne-Mycin (erythromycin)?
    Worth itNot sureNot worth it
    More about EpiduoSide effectsReviews & ratingsFDA package insert
    Have you used Epiduo (adapalene / benzoyl peroxide)?
    Worth itNot sureNot worth it