Compare Erygel vs. Epiduo

Head-to-head comparisons of medication uses, side effects, ratings, and more.


(Adapalene / Benzoyl Peroxide)

Topical treatment for acne. Akne-Mycin (Erythromycin) is a very common acne treatment you apply to the skin that may work better when combined with other topical medicines.Coming soon.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
Reviews for Akne-Mycin (Erythromycin)
of people (All ages) say Akne-Mycin (Erythromycin) is worth it
say it works well
say it's a big hassle
Have you used Akne-Mycin (Erythromycin)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Epiduo (Adapalene / Benzoyl Peroxide)?
Worth itNot sureNot worth it
Side effects

The Erygel FDA package insert doesn’t have numbers about how common side effects are.

More about Erygel side effects »

We haven’t found good data for Epiduo side effects.

FDA side effect reports for Epiduo »
How it works
Akne-Mycin (Erythromycin) is a topical antibiotic. It fights bacteria that cause acne in oil (sebaceous) glands, and contains alcohol which dries out acne-affected areas.Coming soon.
Type of medication
Acne agent
Prescription only
Coming soon.
Available as
  • Cream, gel, or ointment
  • Topical solution
  • Cream, gel, or ointment
Used for (click to learn more)
  • Acne vulgaris
Risk factors for serious side effects
    • Using other medicines or products that irritate the skin
    • Eczema
    • Extreme temperatures (hot or cold)
      Detailed Akne-Mycin (Erythromycin) risks & warnings »
      Coming soon.
      Pregnancy category
      BFDA pregnancy category (Probably safe)

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      See the FDA package insert
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      No specific sleep related info.
      Upsides and benefits
      • Applying erythromycin to the skin reduces the amount of acne bacteria and "calms" the skin down (lowers the inflammatory response) in acne.
      • Available in a gel formulation which may be better if your skin is very oily.
      • Better choice if you're pregnant. erythromycin is categorized as pregnancy Category B (likely safe) as compared to similar topical medicines that are Category C (weigh risks vs benefits).
      Coming soon.
      Downsides and risks
      • There's a risk of irritation with anything you apply to your skin and this is no different. erythromycin, like other topical antibiotics, can cause skin irritation and may appear as redness, peeling, abnormal dryness or stinging, tightening, or burning sensations.
      • It's rare, that a serious allergic reaction would occur, but it's a good idea to test a small area of skin before using on any larger or sensitive areas
      • Studies show it works better when combined with other topical medicines to fight acne and reduce the risk of it losing its effectiveness over time.
      • Can cause severe inflammation of the large intestine (pseudomembranous colitis)
      • Stop using if you don't notice any improvement in your acne after 6-8 weeks. The most time you can use it is three months.
      Coming soon.
      Tips from our pharmacists for people taking the medication
      • Very commonly used topical antibiotic to treat acne.
      • The only topical erythromycin in a gel formula.
      • Apply a thin film to clean and dry affected skin once or twice a day.
      • It may take 6-8 weeks before you see improvement in your acne.
      • Avoid getting into your eyes, nose or mouth.
      • Let your doctor know if you notice abdominal discomfort, pain or diarrhea after starting this medicine.
      • Using a moisturizer that doesn't block your pores (non-comedogenic) may help lessen common side effects of skin dryness and peeling.
      • Taking good care of your skin is an important part of treating acne. Lightly wash with warm water and non-soap-based or gentle cleanser.
      Coming soon.
      Learn more
      More about ErygelSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Akne-Mycin (Erythromycin)?
      Worth itNot sureNot worth it
      More about EpiduoSide effectsReviews & ratingsFDA package insert
      Have you used Epiduo (Adapalene / Benzoyl Peroxide)?
      Worth itNot sureNot worth it